Results 111 to 120 of about 22,691 (239)

Traditional Uses, Phytochemistry, and Multi‐Target Pharmacological Activities of Senna alexandrina

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Senna alexandrina is a medicinally important plant with documented use across Traditional Chinese, Islamic, Ayurvedic, and Unani medicine systems. Phytochemical investigations have yielded 219 characterized compounds, predominantly anthraquinones, flavonoids, and polysaccharides, distributed across leaves, pods, and aerial parts.
Diana Afrina Rella, Khai‐Lin Hew, Yeun‐Mun Choo   +2 more
wiley   +1 more source

Selective cytoprotection by amifostine (A) in the treatment of head and neck cancer with simultaneous radiochemotherapy (RCT)

, 1997
Selective cytoprotection by amifostine (A) in the treatment of head and neck cancer with simultaneous radiochemotherapy ...
K Kuttner (16408203), J Schuth (16408209), J Buntzel (16408200), L Russell (7919177), W Oster (16408206), M Glatzel (16408212)   +5 more
core   +1 more source

Rethinking Melatonin Dosing: Safety and Efficacy at Higher-than-Usual Levels in Aged Patients with Sleep Disturbances and Comorbidities

Brain Sciences
Background. Although melatonin is widely used in Sleep Medicine for its chronobiological action, its potent antioxidant and mitochondrial regulatory effects, as well as its immunomodulatory and anti-inflammatory functions, make it of interest as a ...
Stella M. Valiensi, Vanesa A. Vera, Agustín L. Folgueira, Sofía Caporale, Marcela Ponce de León, Isis Pino Fernández, Daniel E. Vigo, Daniel P. Cardinali   +7 more
doaj   +1 more source

Coordinated TNF–NF‐κB and PI3K–Akt Modulation by Yueju Pill in Hashimoto's Thyroiditis: A Network Pharmacology and Molecular Docking Study

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Network pharmacology and molecular docking identify a coordinated dual‐axis regulatory framework for Yueju pill in Hashimoto's thyroiditis. Candidate compounds and prioritized targets converge on TNF–NF‐κB inflammatory and PI3K–Akt survival/apoptosis signaling, providing computational support for a testable multi‐target hypothesis requiring ...
Hao Zhang, Kuojun Ren, Shengying Wang
wiley   +1 more source

Plant‐Derived Polyphenol Salvianolic Acid B Attenuates Cardiomyocyte Pyroptosis by Modulating the MMP12–NLRP3 Signaling Axis

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
HG induces MMP12 upregulation in AC16 cardiomyocytes, which activates the NLRP3 inflammasome, triggers GSDMD‐mediated pyroptosis, and promotes the release of inflammatory cytokines. Sal B alleviates cardiomyocyte damage by modulating MMP12, while MMP12 overexpression abrogates this protective effect.
Zilong Xie, Zhi‐Kai Yang, Longhui Zheng, Pinghua Wu, Shengxian Chen, Xiaotong Ye, Yi Gao   +6 more
wiley   +1 more source

Mild irritants prevent gastric necrosis through "adaptive cytoprotection" mediated by prostaglandins

, 1983
Several prostaglandins (PG) were found earlier to be cytoprotective for the stomach and the intestine. We now report that mild irritants, given intragastrically, are also cytoprotective by stimulating the release of PG by the stomach.
A. Robert, C. Lancaster, J. P. Davis, A. J. Hanchar, S. O. Field, J. E. Nezamis   +5 more
core   +1 more source

Therapeutic hypothermia with rapid thin liquid convection is safe and feasible in acute ischemic stroke patients: the SISCO pilot study

Frontiers in Neurology
BackgroundLaboratory studies have shown that rapid therapeutic hypothermia (TH) of <34 °C can reduce stroke infarct volume by over 50%. The EuroHyp-1 and ICTUS 2/3 trials found no benefits in the slow cooling of ischemic stroke patients, while ...
Justin A. Salerian, Robert B. Schock, Clemens M. Schirmer, Souvik Sen, Sheryl Martin-Schild, Oded Goren, Douglas F. Kupas, Robert J. Freedman, Aimee Aysenne   +8 more
doaj   +1 more source

Comparative Evaluation of White Quinoa and Tri‐Color Quinoa on Indomethacin‐Induced Gastrointestinal Damage

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
This graphical abstract presents a comparative study on the gastroprotective efficacy of white versus tri‐color quinoa in male rats against indomethacin‐induced gastric injury. Following a 21‐day dietary intervention with either white or tri‐color quinoa, indomethacin was administered to induce gastric damage. Molecular docking analysis revealed strong
Nasser S. Alqahtani, Hanaa M. Hassan, Hanaa M. Mohamed, Fawzia M. Gazaly, Ragaa A. Sadeek   +4 more
wiley   +1 more source

Preventive cytoprotection in social diseases

Терапевтический архив, 2015
Among many cytoprotective drugs, only a few of them that have a targeted metabolic effect include agents that partially inhibit oxidation of free fatty acids, the so-called p-FOX inhibitors (partial fatty acid oxidation inhibitors). Aim.
A S Skotnikov, G N Gorokhovskaya, A M Shilov, V L Yun, M A Khamurzova   +4 more
doaj  

Luteolin Alleviates Axitinib‐Induced Cardiomyocyte Apoptosis in Mice

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
Luteolin alleviates axitinib‐induced cardiomyocyte apoptosis in C57BL/6 mice. ABSTRACT Axitinib, a tyrosine kinase inhibitor (TKI), is associated with a risk of cardiotoxicity in clinical practice. However, its underlying toxicological mechanisms remain unclear, and effective cardioprotective strategies are lacking.
Si‐Wen Ji, Xu Li, Dong Tang, Lin Bai, Chun‐Lei Yu, Na Niu   +5 more
wiley   +1 more source