Results 201 to 210 of about 15,403 (255)

A Roadmap for Using Hybridisation Capture–Based Target Enrichment of Ancient Environmental DNA in Palaeoecology

Molecular Ecology Resources, Volume 26, Issue 5, July 2026.
ABSTRACT Recovering ancient DNA from environmental samples is transforming the way we understand historical ecosystems. While high‐throughput sequencing of the total DNA in environmental samples (shotgun metagenomic sequencing) reveals the taxonomic contents of these samples, the genetic signals of some taxa (e.g., eukaryotes) can be weak compared to ...
Nicole R. Foster, Luke E. Holman, Linda Armbrecht, Jérémy Courtin, Theis Jensen, Mikkel Winther Pedersen, Lennart Schreiber, Hannes Schroeder, Frederik V. Seersholm, Giulia Zampirolo, Kristine Bohmann, Heike H. Zimmermann   +11 more
wiley   +1 more source

Homozygous Loss‐of‐Function Variant in SLC20A1 Coding for Ubiquitous Phosphate Transporter PiT1 Is Associated With Multiple Developmental Abnormalities

Clinical Genetics, Volume 110, Issue 1, Page 64-72, July 2026.
Biallelic SLC20A1 loss‐of‐function variant causes a previously unrecognized multisystem developmental disorder. We report the first homozygous case presenting with tetralogy of Fallot, renal agenesis, polydactyly, and growth impairment. Transcriptome analysis of patient‐derived fibroblasts suggests significant dysregulation of pathways critical for ...
Eugénie Koumakis, Céline Huber, Wendy Chung, Christine Leroy, Pauline Parisot, Regis Gaudin, Mohamad Zaidan, Valérie Cormier‐Daire, Gérard Friedlander, Yoel Hirsch   +9 more
wiley   +1 more source

Genotoxicity profiling reveals distinct platform-and cell type-specific effects in therapeutic gene editing for genetic hyperinflammation. [PDF]

Cell Stem Cell
Lei L, Kaufmann MM, Lao J, Thoulass G, Ammann S, Xiao H, Rhiel M, Dettmer-Monaco V, Grünewald J, Andrieux G, Alzubi J, Miller BR, Weißert K, Gräßel L, Schell C, Illert AL, Joung JK, Boerries M, Cornu TI, Ehl S, Erlacher M, Aichele P, Cathomen T.   +22 more
europepmc   +1 more source

The Molecular Diagnosis of Myopathies: Integrating Genomic, Proteomic, and Pathological Insights Toward Precision Medicine

Clinical Genetics, Volume 110, Issue 1, Page 15-28, July 2026.
Advances in genomic, proteomic, and transcriptomic technologies are transforming the diagnosis of genetic myopathies. When integrated with traditional muscle pathology, multi‐omics approaches improve diagnostic yield, clarify disease mechanisms, and support more precise, mechanism‐based therapeutic strategies for patients with neuromuscular disorders ...
Ludmila Alem, Denise de Abreu Pereira, Katia Carneiro   +2 more
wiley   +1 more source

Editing and synthetic engineering of chloroplast genomes. [PDF]

Plant Commun
Fu J, Zhang J.
europepmc   +1 more source

Cytosolic delivery of bacterial metabolites by riboflavin transporters promotes MR1 antigen presentation and MAIT cell recognition

Immunology &Cell Biology, Volume 104, Issue 6, Page 595-608, July 2026.
VitBAg antigen presentation is promoted through a cytosolic pathway that reaches ligand‐receptive MR1 to present to MAIT cells, like the riboflavin transport pathway. Riboflavin solute carrier transporters can promote this MR1 presentation, but they are not essential for this role, suggesting redundant pathways to uptake VitBAg.
Sebastian Cruz‐Gomez, Hui Jing Lim, Brunda Nijagal, Yuting Yang, Nicole Lau, Jeffrey YW Mak, David P Fairlie, Hayley Newton, Mariolina Salio, Jose A Villadangos, Hamish EG McWilliam   +10 more
wiley   +1 more source

On the Calculations of Electron Impact Ionization Cross-Sections for Selected Nucleosides and Deoxyribose Molecules. [PDF]

Molecules
Możejko P.
europepmc   +1 more source

Hidden Species Diversity in Sulfonecta Jankowski, 1978 (Ciliophora: Armophorea): Integrative Evidence for a New Species and Reassessment of the Type Species

Journal of Eukaryotic Microbiology, Volume 73, Issue 4, July/August 2026.
ABSTRACT Research on anaerobic ciliates has intensified over the past decades, with Armophorea being most studied, but members of Armophorida remaining relatively understudied. Previously, the genus Sulfonecta Jankowski, 1978 was monotypic, with S. uniserialis (Levander, 1894) Jankowski, 1978 as the type species.
Nanda Dwi Kristanti, Quoc Dung Nguyen, Borong Lu, Novia Cahyani, Mann Kyoon Shin   +4 more
wiley   +1 more source

Therapeutic adenine base editor with minimized off-target effects. [PDF]

Protein Cell
Sun Y, Yan N, Feng H, Lu H, Zuo Z, Zhou C, Zuo E.   +6 more
europepmc   +1 more source

Pentatricopeptide repeat proteins in crops: Advances in functional mechanisms and breeding applications

Journal of Integrative Plant Biology, Volume 68, Issue 7, Page 1973-2000, July 2026.
Pentatricopeptide repeat proteins coordinate nucleus‐organelle communication by modulating RNA metabolism within chloroplasts and mitochondria. This review highlights how they control critical processes like photosynthesis, seed development, fertility restoration, and stress survival in crops, and explores their potential as programmable tools for RNA ...
Mingming Wu, Maohong Cai, Rongrong Zhai, Jing Ye, Guofu Zhu, Faming Yu, Shenghai Ye, Xiaoming Zhang   +7 more
wiley   +1 more source