Results 201 to 210 of about 15,248 (235)

Recent Advances in Searching for DNMT Inhibitors and Their Potential Application in Treating Human Diseases. [PDF]

Int J Mol Sci
Bulygin AA, Davletgildeeva AT, Kuznetsov NA.   +2 more
europepmc   +1 more source

Mutagenicity and Repair of Acrolein Adduct to Cytosine. [PDF]

Int J Mol Sci
Dylewska M, Kasperowicz S, Sokołowska B, Maciejewska AM.   +3 more
europepmc   +1 more source

The potential of methylation signal detection in eDNA toward functional ecological monitoring. [PDF]

Commun Biol
Liu C, Fei X, Hirayama IT, Yagi G, Ushio M.   +4 more
europepmc   +1 more source

Rationally and in silico guided APOBEC3F-directed CBE for enhanced PDAC genetic therapy. [PDF]

Commun Biol
Fang Q, Zhang J, Wang K, Wang Z, Lv Z, Zhang X, Bi C, Zhang X, Yu J, Feng Y, Zhou T, Hao J, Yang C.   +12 more
europepmc   +1 more source

Editing mitochondrial and chloroplast genomes : Genome editing technologies for plant organelles provide new opportunities in functional genomics and breeding. [PDF]

EMBO Rep
Forner J, Bock R.
europepmc   +1 more source

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Dual base editor catalyzes both cytosine and adenine base conversions in human cells

Nature Biotechnology, 2020
Although base editors are useful tools for precise genome editing, current base editors can only convert either adenines or cytosines. We developed a dual adenine and cytosine base editor (A&C-BEmax) by fusing both deaminases with a Cas9 nickase to achieve C-to-T and A-to-G conversions at the same target site. Compared to single base editors, A&C-BEmax'
Mingyao Liu, Yukio Nakamura, Li Yang
exaly   +3 more sources

Precise mutagenesis in zebrafish using cytosine base editors

Nature Protocols, 2023
Base editing is a powerful CRISPR-based technology for introducing precise substitutions into the genome. This technology greatly advances mutagenesis possibilities in vivo, particularly in zebrafish, for which the generation of precise point mutations is still challenging.
Marion Rosello, Malo Serafini, Jean-Paul Concordet, Filippo Del Bene   +3 more
openaire   +2 more sources

Germline Editing of Drosophila Using CRISPR-Cas9-Based Cytosine and Adenine Base Editors

The CRISPR Journal, 2023
Target-AID, BE3, and ABE7.10 base editors fused to the catalytically modified Cas9 and xCas9(3.7) were tested for germline editing of the fruit fly Drosophila melanogaster . We developed a guide RNA-expressing construct, white- 4gRNA, targeting splice ...
Nirav Thakkar, Adela Hejzlarova, Vaclav Brabec, David Dolezel   +3 more
openaire   +3 more sources

Adenine base editors catalyze cytosine conversions in human cells

Nature Biotechnology, 2019
Adenine base editors comprise an adenosine deaminase, evolved in vitro, and a Cas9 nickase. Here, we show that in addition to converting adenine to guanine, adenine base editors also convert cytosine to guanine or thymine in a narrow editing window (positions 5-7) and in a confined TC*N sequence context.
Heon Seok Kim, You Kyeong Jeong, Junho K Hur, Jin-Soo Kim, Sangsu Bae   +4 more
openaire   +2 more sources