Results 41 to 50 of about 5,939,536 (365)

Bim and Bmf synergize to induce apoptosis in Neisseria gonorrhoeae infection [PDF]

, 2009
: Bcl-2 family proteins including the pro-apoptotic BH3-only proteins are central regulators of apoptotic cell death. Here we show by a focused siRNA miniscreen that the synergistic action of the BH3-only proteins Bim and Bmf is required for apoptosis ...
A Cuconati, A Gross, A Muller, A Zychlinsky, AG Letai, B Antonsson, C Dehio, CR Hauck, DR Green, E Oda, EM Kupsch, FJ Bauer, G Kroemer, Guido Kroemer, H Kim, H Puthalakath, H Puthalakath, H. Steven Seifert, HL Howie, IM Mosleh, J Zha, JB Bliska, K Lei, K Nakano, K Rajalingam, K Rajalingam, K Wang, Kathleen Gottschalk, Krishnaraj Rajalingam, L Chen, M Naumann, M Naumann, M Naumann, MA Apicella, MC Wei, N Machuy, N Tajeddine, Nikolaus Machuy, O Billker, O Kepp, Oliver Kepp, P Massari, P Muenzner, P Muenzner, PF Cartron, S Cory, S Makino, SE McCaw, SM Frisch, SN Willis, T Kuwana, T Rudel, T Schmelzle, Thomas Rudel, Volker Brinkmann, Yuri Churin, Z Xia   +56 more
core   +4 more sources

High-Frequency Irreversible Electroporation (H-FIRE) Induced Blood–Brain Barrier Disruption Is Mediated by Cytoskeletal Remodeling and Changes in Tight Junction Protein Regulation

Biomedicines, 2022
Glioblastoma is the deadliest malignant brain tumor. Its location behind the blood–brain barrier (BBB) presents a therapeutic challenge by preventing effective delivery of most chemotherapeutics.
Brittanie R. Partridge, Yukitaka Kani, Melvin F. Lorenzo, Sabrina N. Campelo, Irving C. Allen, Jonathan Hinckley, Fang-Chi Hsu, Scott S. Verbridge, John L. Robertson, Rafael V. Davalos, John H. Rossmeisl   +10 more
doaj   +1 more source

Motor proteins traffic regulation by supply-demand balance of resources

, 2014
In cells and in vitro assays the number of motor proteins involved in biological transport processes is far from being unlimited. The cytoskeletal binding sites are in contact with the same finite reservoir of motors (either the cytosol or the flow ...
Ciandrini, Luca, Dauloudet, O., Neri, I., Parmeggiani, A., Walter, Jean-Charles   +4 more
core   +3 more sources

Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma. [PDF]

, 2014
Ewing sarcoma is the second-most-common bone cancer in children. Driven by an oncogenic chromosomal translocation that results in the expression of an aberrant transcription factor, EWS/FLI, the disease is typically aggressive and micrometastatic upon ...
Beckerle, Mary C, Chaturvedi, Aashi, Grossmann, Allie H, Hoffman, Laura M, Jensen, Christopher C, Lessnick, Stephen L, Lin, Yi-Chun, Randall, R Lor, Welm, Alana L   +8 more
core   +1 more source

Cytoskeletal proteins in cortical development and disease: actin associated proteins in periventricular heterotopia

Frontiers in Cellular Neuroscience, 2015
The actin cytoskeleton regulates many important cellular processes in the brain, including cell division and proliferation, migration, and cytokinesis and differentiation. These developmental processes can be regulated through actin dependent vesicle and
Gewei Lian, V. Sheen
semanticscholar   +1 more source

Regulation of store-operated Ca2+ entry by Septins

Frontiers in Cell and Developmental Biology, 2016
The mechanism of store-operated Ca2+entry (SOCE) brings extracellular Ca2+ into cells after depletion of intracellular Ca2+ stores. Regulation of Ca2+ homeostasis by SOCE helps control various intracellular signaling functions in both non-excitable and ...
Bipan Kumar Deb, Gaiti Hasan
doaj   +1 more source

Synthesis of spectrin in avian erythroid cells: association of nascent polypeptide chains with the cytoskeleton [PDF]

, 1983
The site of synthesis of spectrin was investigated in erythroid cells from 10-day chicken embryos. After various periods of [35S]methionine incorporation the cells were lysed in a Triton X-100 (TX-100)-containing buffer and were separated into a TX-100 ...
Blikstad, Ingrid, Lazarides, Elias
core   +2 more sources

Cytoskeletal Remodeling in Cancer

Biology, 2020
Simple Summary Cell migration is an essential process from embryogenesis to cell death. This is tightly regulated by numerous proteins that help in proper functioning of the cell.
J. Aseervatham
semanticscholar   +1 more source

Microtubules in Bacteria: Ancient Tubulins Build a Five-Protofilament Homolog of the Eukaryotic Cytoskeleton [PDF]

, 2011
Microtubules play crucial roles in cytokinesis, transport, and motility, and are therefore superb targets for anti-cancer drugs. All tubulins evolved from a common ancestor they share with the distantly related bacterial cell division protein FtsZ, but ...
A Briegel, A Marchler-Bauer, A. J Koster, A. J Martin-Galiano, Alasdair W. McDowall, B Miroux, C Jenkins, C Suloway, C. A Sontag, C. A Sontag, C. H Aylett, C. V Iancu, D Bermudes, D Nicastro, D Schlieper, D. N Mastronarde, D. N Mastronarde, D. P Devos, E Nogales, E Nogales, E Nogales, E Nogales, E. F Pettersen, E. G Reynaud, E. I Tocheva, F Amat, Giulio Petroni, Grant J. Jensen, H Erickson, H Sui, H. P Erickson, J Cope, J Lowe, J. B Heymann, J. D Thompson, J. D Wisotzkey, J. O McInerney, J. R McIntosh, K. C Lee, K. S Makarova, K. T Tokuyasu, K. T Tokuyasu, L Gan, L Ni, L. A Amos, L. A Amos, Linda Amos, M Pilhofer, M Pilhofer, M Pilhofer, M Takeda, M Wagner, M. S Ladinsky, M. S Ladinsky, Mark S. Ladinsky, Martin Pilhofer, P Forterre, P. J Keeling, R. I Koning, S Vaughan, S. K Dutcher, S. Q Zheng, T Muller, T. K Attwood, W Ludwig, W. F Tivol, Z Li   +66 more
core   +5 more sources

Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics investigation of neurodevelopmental migratory pathways [PDF]

, 2020
Granule cell dispersion (GCD) is a common pathological feature observed in the hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE). Pathomechanisms underlying GCD remain to be elucidated, but one hypothesis proposes aberrant reactivation of
Al-Kaaby, B., Al-Kaaby, B., Dzurova, N., Dzurova, N., Liu, J., Liu, J., Millks, K., Millks, K., Sisodiya, S.M., Sisodiya, S.M., Thom, M., Thom, M.   +11 more
core   +1 more source