Results 111 to 120 of about 812,769 (307)

CD28null CD4 T-cell expansions in autoimmune disease suggest a link with cytomegalovirus infection [PDF]

, 2019
Immunosenescence is thought to contribute to the increase of autoimmune diseases in older people. Immunosenescence is often associated with the presence of an expanded population of CD4 T cells lacking expression of CD28 (CD28null).
A Akbar, A Akbar, A Fasth, A Fasth, A Fasth, A Halenius, A Hsieh, A Kawakami, A Link, A Mak, A Pawlik, A Pawlik, A Pera, A Pera, A Vallejo, A Vallejo, B Broux, B Broux, B Jones, B Weinberger, B Zal, C Bason, C Turesson, D Chanouzas, D Schmidt, D Yang, E Rozenblyum, E Scotet, E Shevach, E van Leeuwen, F Sallusto, F Wang, F Zaguia, G Lee, H Bour-Jordan, H Brok, H Einsele, H Hoff, H Honkanen, H Sawai, H Sawai, H von Boehmer, I Broadley, I Dumitriu, I van der Heijden, J Goronzy, J Goronzy, J Olsson, J Smith-Garvin, J Vrbikova, J Walker, J Yang, K Lafferty, K Maly, K Nozawa, K Sullivan, K Warrington, K Warrington, L Berg, L Calabrese, L Francis, L Haaheim, L Peeters, L Walker, L Wang, M Bajwa, M Ghiti Moghadam, M Holtzman, M Kagnoff, M Slot, M Tejada-Simon, M Thewissen, M Thewissen, M Thewissen, M Ugarte-Gil, M Vanheusden, M Weltevrede, M Zheng, N Jain, N Weng, O Acuto, P Lipsky, P Martens, R Effros, R Gerli, R Ransohoff, R Wildin, S Brugaletta, S Fernandez, S Liossis, S Markovic-Plese, S Piantoni, T Lindstrom, T Namekawa, T Olsson, V Appay, X Zhang, Y Hiromatsu, Y Kita, Y Mehraein, Y Miyazaki, Y Wang, Y Xing, Z Sun, Z Yang   +104 more
core   +1 more source

Harnessing the cytotoxic granule exocytosis to augment the efficacy of T-cell-engaging bispecific antibody therapy

Haematologica
T-cell-engaging bispecific antibody (T-BsAb, also known as BiTE) therapy has emerged as a powerful therapeutic modality against multiple myeloma.
Mika Casey, Carol Lee, Sharon M. Hoyte, Rebecca L. Johnston, Wing Yu Kwok, Soi Cheng Law, Maher K Gandhi, Simon J Harrison, Kyohei Nakamura   +8 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Interleukin-10 containing normal human serum inhibits granzyme B release but not perforin release from alloreactive and EBV-specific T cell clones [PDF]

, 2007
Interleukin-10 (IL-10), also known as cytokine synthesis inhibitory factor, has pleiotropic effects in immunoregulation and inflammation. It is capable of inhibiting synthesis of pro-inflammatory cytokines like interferon γ (IFNγ), IL-2, IL-3,
Hideya Sato, Hitoshi Okazaki, Kenji Tadokoro, Masahiro Satake, Motoko Nishimura   +4 more
core   +2 more sources

Functional characterization of infiltrating T lymphocytes in human hepatic allografts [PDF]

, 1986
We have employed recently developed techniques in T-cell culturing to study the nature and function of infiltrating hepatic allograft T cells. Using the rationale that intragraft T cells are activated during cell mediated damage to the allograft, we were
Adriana Zeevi, Ascher, Bernard, Bono, Brodsky, Brodsky, Brodsky, Burdick, Burdick, Cerilli, Depper, Fiche, Goyert, HancocK, Harty, Hayry, Hoshinaga, Houssin, Iwatsuki, Iwatsuki, Iwatsuki, Jake Demetris, Jeannet, John J. Fung, Kim, Kolbeck, Lampson, Marboe, Mayer, Moreau, Palacios, Paradis, Pober, Rene J. Duquesnoy, Roberts, Shaw, Shunzaburo Iwatsuki, Snover, Spits, Starzl, Steinmuller, Stelzer, Strassman, Thomas E. Starzl, Thompson, Thorley-Lawson, Tilney, van Es, Weintraub, Zeevi, Zeevi, Zeevi, Zeevi, Zeevi   +53 more
core   +1 more source

Imbalance of T Lymphocyte Subsets in Adult Immune Thrombocytopenia

International Journal of General Medicine, 2021
Xiuxiu Lin,1 Anhui Xu,1 Li Zhou,1 Na Zhao,1 Xinhui Zhang,2 Jin Xu,3 Shanglong Feng,2 Changcheng Zheng1 1Department of Hematology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China,
Lin X, Xu A, Zhou L, Zhao N, Zhang X, Xu J, Feng S, Zheng C   +7 more
doaj  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Steroid resistant CD8(+)CD28(null) NKT-like pro-inflammatory cytotoxic cells in chronic obstructive pulmonary disease [PDF]

, 2016
This article is part of the Research Topic On the Origin and Function of Human NK-like CD8+ T Cells: Charting New TerritoriesCorticosteroid resistance is a major barrier to effective treatment in chronic obstructive pulmonary disease (COPD), and failure ...
Hodge, G., Hodge, S.
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes. [PDF]

, 1992
Engagement of the CD3/T cell antigen receptor complex on small, resting T cells is insufficient to trigger cell-mediated cytotoxicity or to induce a proliferative response.
Azuma, M, Buck, D, Cayabyab, M, Lanier, LL, Phillips, JH   +4 more
core   +1 more source