Results 241 to 250 of about 407,636 (275)
Frontiers in Plant Science, 2013 Oligogalacturonides (OGs) are oligomers of alpha-1,4-linked galacturonosyl residues released from plant cell walls upon partial degradation of homogalacturonan.
Simone Ferrari +2 more
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Redox-derived damage-associated molecular patterns: Ligand function of lipid peroxidation adducts
Redox Biology, 2013 Endogenous electrophiles, such as α,β-unsaturated aldehydes and ketones generated during lipid peroxidation, exhibit a facile reactivity with proteins, generating a variety of intra and intermolecular covalent adducts.
Koji Uchida
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Metabolite‐derived damage‐associated molecular patterns in immunological diseases
The FEBS Journal, 2023Damage‐associated molecular patterns (DAMPs) are typically derived from the endogenous elements of necrosis cells and can trigger inflammatory responses by activating DAMPs‐sensing receptors on immune cells. Failure to clear DAMPs may lead to persistent inflammation, thereby contributing to the pathogenesis of immunological diseases.
Na Kang +11 more
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Damage‐associated molecular patterns and immune activation in bipolar disorder
Acta Psychiatrica Scandinavica, 2015ObjectiveImmune activation in bipolar disorder (BD) has been frequently reported. Damage‐associated molecular patterns (DAMPs) are key players in the immune activation reaction. The aim of this study was to assess DAMP levels in drug‐free patients with BD during acute episodes.MethodSerum levels of a predetermined set of DAMPs were assessed in drug ...
Laura Stertz +2 more
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NEUTROPHIL HETEROGENEITY IN SEPSIS: THE ROLE OF DAMAGE-ASSOCIATED MOLECULAR PATTERNS
Shock, 2022ABSTRACT Sepsis is a severe inflammatory disease syndrome caused by the dysregulated host response to infection. Neutrophils act as the first line of defense against pathogens by releasing effector molecules such as reactive oxygen species, myeloperoxidase, and neutrophil extracellular traps.
Atsushi, Murao +2 more
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Damage-Associated Molecular Patterns As Double-Edged Swords in Sepsis
Antioxidants & Redox Signaling, 2021Significance: Sepsis is defined as a life-threatening organ dysfunction caused by dysregulated host response to infection. This leads to an uncontrolled inflammatory response at the onset of infection, followed by immunosuppression. The development of a specific treatment modality for sepsis is still challenging,
Mian, Zhou, Monowar, Aziz, Ping, Wang
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Damage-Associated Molecular Patterns and Systemic Signaling
Phytopathology®Cellular damage inflicted by wounding, pathogen infection, and herbivory releases a variety of host-derived metabolites, degraded structural components, and peptides into the extracellular space that act as alarm signals when perceived by adjacent cells.
Fiona M. Harris, Zhonglin Mou
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Extracellular histones as damage-associated molecular patterns in neuroinflammatory responses
Reviews in the Neurosciences, 2022Abstract The four core histones H2A, H2B, H3, H4, and the linker histone H1 primarily bind DNA and regulate gene expression within the nucleus. Evidence collected mainly from the peripheral tissues illustrates that histones can be released into the extracellular space by activated or damaged cells. In this article, we first summarize the
Christy M. Richards +3 more
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Damage-associated molecular patterns and their pathological relevance in diabetes mellitus
Ageing Research Reviews, 2015Diabetes, a group of metabolic and age-related diseases, is a major global health problem, the incidence of which has increased dramatically in recent decades. Type 1 diabetes mellitus (T1DM) is a complex, T cell-mediated autoimmune disease characterized by immune cell infiltration and chronic inflammation in the islets of Langerhans.
Shin, Jung Jae +3 more
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Damage‐Associated Molecular Patterns in the Course of Lung Cancer – A Review
Scandinavian Journal of Immunology, 2015AbstractMore than 20 years ago, the ‘danger theory’ was proposed which explains why potent immune responses with no microbial components are elicited against tissue transplants, injuries, tumours and autoimmune diseases. It states that the immune system can distinguish between dangerous and innocuous endogenous signals.
M, Łagiedo, J, Sikora, M, Kaczmarek
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