Natural killer cell response to chemotherapy-stressed cancer cells: Role in tumor immunosurveillance. [PDF]
, 2017 Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic development, growth, and metastatic dissemination in a process called cancer immunosurveillance.
Borrelli, Cristiana +5 more
core +1 more source
Eosinophils Oxidize Damage-Associated Molecular Pattern Molecules Derived from Stressed Cells [PDF]
The Journal of Immunology, 2009 Abstract Eosinophils (Eos) are found at increased numbers within necrotic areas of tumors. We show that necrotic material from cell lysates containing damage-associated molecular pattern molecules induce eosinophil degranulation (release of major basic protein and eosinophil peroxidase) and enhance their oxidative burst while the ...
Lotfi, Ramin +7 more
openaire +3 more sources
The Growing Threat of Agroterrorism and Strategies for Agricultural Defense [PDF]
, 2020 Due to the dynamic nature of human conflict, non-traditional terror tactics have evolved to undermine the socioeconomic stability of targeted societies.
Forrest, Alyssa
core +1 more source
Holography and Coherent Diffraction with Low-Energy Electrons: A Route towards Structural Biology at the Single Molecule Level [PDF]
, 2015 The current state of the art in structural biology is led by NMR, X-ray crystallography and TEM investigations. These powerful tools however all rely on averaging over a large ensemble of molecules.
Escher, Conrad +3 more
core +1 more source
Research progress on damage ⁃ associated molecular patterns in intracerebral hemorrhage
Chinese Journal of Contemporary Neurology and Neurosurgery, 2021 After the onset of intracerebral hemorrhage (ICH), the immune storm causes the massive death of neurons and their supporting cells. Cytotoxic substances such as hemoglobin, heme and iron ions released by red blood cells lysis also promote death of ...
YU Zhi⁃yuan +4 more
doaj
Endotracheal tube-induced sore throat pain and inflammation is coupled to the release of mitochondrial DNA [PDF]
, 2017 In the absence of infection, the pathophysiology of endotracheal tube-induced sore throat pain is unclear. Activated neutrophils release elastase, reactive oxygen species, and inflammatory cytokines known to contribute to neuropathic pain. Sterile tissue
Earhart, Alexander +9 more
core +2 more sources
Peptide Aggregation Induced Immunogenic Rupture (PAIIR)
Advanced Science, 2022 Immunogenic cell death (ICD) arises when cells are under stress, and their membranes are damaged. They release damage‐associated molecular patterns (DAMPs) that stimulate and drive the type and magnitude of the immune response.
Gokhan Gunay +5 more
doaj +1 more source
Evaluation of the zucker diabetic fatty (ZDF) rat as a model for human disease based on urinary peptidomic profiles [PDF]
, 2012 Representative animal models for diabetes-associated vascular complications are extremely relevant in assessing potential therapeutic drugs. While several rodent models for type 2 diabetes (T2D) are available, their relevance in recapitulating renal and ...
Antonia Vlahou +43 more
core +3 more sources
Reformulating Pro-Oxidant Microglia in Neurodegeneration [PDF]
, 2019 In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent genome-wide transcriptomic analyses of microglial cells under different disease conditions have uncovered a new subpopulation named ...
Alonso Bellido, Isabel María +13 more
core +2 more sources
Frontiers in ImmunologyToll-like receptor 4 (TLR4) is a pattern recognition receptor that binds to pathogen associated molecular patterns (PAMPs) and damage associated molecular patterns (DAMPs). Binding of exogenous or endogenous ligands activates the TLR4 pathway and induces
Phoebe Crammond +4 more
doaj +1 more source