Results 91 to 100 of about 59,000 (187)

Pattern Recognition Receptors and the Host Cell Death Molecular Machinery

Frontiers in Immunology, 2018
Pattern Recognition Receptors (PRRs) are proteins capable of recognizing molecules frequently found in pathogens (the so-called Pathogen-Associated Molecular Patterns—PAMPs), or molecules released by damaged cells (the Damage-Associated Molecular ...
Gustavo P. Amarante-Mendes, Gustavo P. Amarante-Mendes, Sandy Adjemian, Sandy Adjemian, Laura Migliari Branco, Laura Migliari Branco, Larissa C. Zanetti, Ricardo Weinlich, Karina R. Bortoluci, Karina R. Bortoluci   +9 more
doaj   +1 more source

Redox-derived damage-associated molecular patterns: Ligand function of lipid peroxidation adducts

Redox Biology, 2013
Endogenous electrophiles, such as α,β-unsaturated aldehydes and ketones generated during lipid peroxidation, exhibit a facile reactivity with proteins, generating a variety of intra and intermolecular covalent adducts.
Koji Uchida
doaj   +1 more source

Extracellular RNA mediates iron-induced toxicity and inflammatory signalling in hepatic cells

Toxicology Reports
Hepatic iron accumulation and toxicity is a frequent finding in chronic liver diseases such as hereditary hemochromatosis (HH), metabolic associated fatty liver disease (MASLD), alcoholic liver disease (ALD) and hepatitis C virus (HCV) infection, however,
Sana Raza, Archana Tewari, Sangam Rajak, Pratima Gupta, Rohit A. Sinha   +4 more
doaj   +1 more source

Toll-Like Receptors in Liver Fibrosis: cellular crosstalk and mechanisms

Frontiers in Physiology, 2012
Toll-like receptors (TLRs) are pattern recognition receptors that distinguish conserved microbial products, also known as pathogen-associated molecular patterns (PAMPs), from host molecules.
Ling eYang, Ekihiro eSeki
doaj   +1 more source

Comprehending toll-like receptors: pivotal element in the pathogenesis of sepsis and its complications

Frontiers in Immunology
Sepsis, a critical systemic inflammatory response syndrome elicited by pathogenic microorganisms, poses a significant challenge in clinical practice due to its rapid progression and potential for multi-organ failure.
Wei Wang, Shengtian Mu, Dongli Yan, Huan Qin, Zhen Zheng   +4 more
doaj   +1 more source

Is There a Relationship Between Damage-Associated Molecular Patterns (DAMPs) And Colorectal Cancer?

International Journal of Human and Health Sciences (IJHHS)
Objectives: Interleukin 1 α (IL-1α) and High Mobility Group Box 1 (HMGB1) are damage-associated molecular patterns (DAMPs), which have been associated with cancer progression by promoting proliferation, angiogenesis, invasion, and metastasis. This study aimed to determine the expression of IL-1α and HMGB1 in CRC tumours compared to their normal tissue ...
Elsa Haniffah Mejia Mohamed, Cheng Kim Jun, Suha Azizan, Xue Jing Jong, Khong Tak Loon, Toh Yeh Fa, Bunita Kumari Hari Chand, Zaridatul Aini Ibrahim   +7 more
openaire   +1 more source

Ultra-small NIR-Responsive Nanotheranostic Agent for Targeted Photothermal Ablation Induced Damage-Associated Molecular Patterns (DAMPs) from Post-PTT of Tumor Cells Activate Immunogenic Cell Death. [PDF]

Nanotheranostics, 2023
Sobhana S, Sarathy NP, Karthikeyan L, Shanthi K, Vivek R.   +4 more
europepmc   +1 more source

E14 Damage associated molecular pattern molecules (DAMPs) redox and autophagy [PDF]

Journal of Crohn's and Colitis Supplements, 2010
M.T. Lotze, D. Tang, W.J. Buchser, X. Liang, M. DeVera, S.E. Plevy, E. John, B. Pitt, P.H. Basse, L. Butterfield, P. Kalinski, H.J. Zeh, R. Lotfi, A. Rubartelli   +13 more
openaire   +1 more source

Immune targets in the tumor microenvironment treated by radiotherapy. [PDF]

, 2019
Radiotherapy (RT), the major anti-cancer modality for more than half of cancer patients after diagnosis, has the advantage of local tumor control with relatively less systematic side effects comparing to chemotherapy.
Li, Jian Jian, Ozpiskin, Omer M, Zhang, Lu   +2 more
core  

The Damage-Associated Molecular Patterns (DAMPs) as Potential Targets to Treat Osteoarthritis: Perspectives From a Review of the Literature. [PDF]

Front Med (Lausanne), 2020
Lambert C, Zappia J, Sanchez C, Florin A, Dubuc JE, Henrotin Y.   +5 more
europepmc   +1 more source