Results 161 to 170 of about 40,224 (193)

Mesoporous Silica Nanoparticles With Customized Drug Ratio/Loading for Effective Treatment of Gemcitabine‐Resistant Pancreatic Tumors

Advanced NanoBiomed Research, EarlyView.
Redox responsive mesoporous silica nanoparticles (MSNs) were engineered to deliver gemcitabine (Gem) and cisplatin (cisPt) at defined ratios to overcome chemoresistance in pancreatic ductal adenocarcinoma (PDAC). Optimized Gem MSNs and Gem cisPt MSNs enhanced cytotoxicity in murine and human Gem resistant models, with select formulations inducing ...
Tamanna Binte Huq, Sudip Kumar Dam, Doaha Awad, Punnya Anil Kumar Jeeja, Farzana Ferdous, Juan L. Vivero‐Escoto   +5 more
wiley   +1 more source

Cell death in sepsis: unveiling new perspectives on organ dysfunction. [PDF]

Front Cell Dev Biol
Jiang R, Cai P.
europepmc   +1 more source

Divergent immune cascades activated by metabolic versus mechanical exercise intensity: revisiting cytokine heterogeneity in "moderate-intensity exercise". [PDF]

Front Immunol
Wang JW, Xun JJ, Jian LN.
europepmc   +1 more source

Macrophage polarization in ischemia-reperfusion injury: from molecular mechanisms to therapeutic strategies. [PDF]

Front Immunol
Han X, Zheng A, Du P, Wang Y, Li Z, Hu Y, Gao F, Li M, Guo J, Ma X.   +9 more
europepmc   +1 more source

Cuproptosis in Sepsis: Cell Type-Specific Mechanisms and Clinical Prospects. [PDF]

Drug Des Devel Ther
Fang S, Li W, Chang Z, Tang X, Niu X, Chen Y, Hu X.   +6 more
europepmc   +1 more source

Damage-associated molecular patterns and coagulation. [PDF]

Br J Haematol
Yong J, Toh CH.
europepmc   +1 more source

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Plant immunity by damage-associated molecular patterns (DAMPs)

Essays in Biochemistry, 2022
AbstractRecognition by plant receptors of microbe-associated molecular patterns (MAMPs) and pathogenicity effectors activates immunity. However, before evolving the capacity of perceiving and responding to MAMPs and pathogenicity factors, plants, like animals, must have faced the necessity to protect and repair the mechanical wounds used by pathogens ...
Giulia de Lorenzo, Felice Cervone, Kostya Kanyuka   +2 more
exaly   +3 more sources

Natural antibodies as a sensor of electronegative damage-associated molecular patterns (DAMPs)

Free Radical Biology and Medicine, 2014
Natural antibodies (Abs), predominantly IgMs, play an important function in the host response to the recognition of endogenous danger signals called damage-associated molecular patterns (DAMPs). Many of the natural IgM Abs also show several different antigenic cross-reactivities toward covalently modified proteins, such as oxidized low-density ...
Koji Uchida
exaly   +3 more sources

Damage-Associated Molecular Patterns (DAMPs) in Plant Innate Immunity: Applying the Danger Model and Evolutionary Perspectives

Annual Review of Phytopathology, 2021
Danger signals trigger immune responses upon perception by a complex surveillance system. Such signals can originate from the infectious nonself or the damaged self, the latter termed damage-associated molecular patterns (DAMPs). Here, we apply Matzinger's danger model to plant innate immunity to discuss the adaptive advantages of DAMPs and their ...
Kiwamu Tanaka, Martin Heil
exaly   +3 more sources