Results 171 to 180 of about 40,224 (193)

Eosinophilic Granulocytes and Damage-associated Molecular Pattern Molecules (DAMPs)

Journal of Immunotherapy, 2007
The development of a tumor over many years typically leads to reciprocal alternations in the host and the tumor, enabling tumor growth paradoxically in the setting of substantial necrosis and inflammation. When evaluating a tumor, it is important to assess 3 elements: (1) the quantity and quality of tumor-associated leukocytes, (2) their state of ...
Ramin, Lotfi, James J, Lee, Michael T, Lotze   +2 more
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Extracellular Matrix–Derived Damage-Associated Molecular Patterns (DAMP): Implications in Systemic Sclerosis and Fibrosis

Journal of Investigative Dermatology, 2023
Damage-associated molecular patterns (DAMPs) are intracellular molecules released under cellular stress or recurring tissue injury, which serve as endogenous ligands for toll-like receptors (TLRs). Such DAMPs are either actively secreted by immune cells or passively released into the extracellular environment from damaged cells or generated as ...
Swarna Bale, Priyanka Verma, John Varga, Swati Bhattacharyya   +3 more
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Targeting Damage-Associated Molecular Pattern Molecules (DAMPs) and DAMP Receptors in Melanoma

2013
Damage-associated molecular pattern molecules (DAMPs) are proteins released from cells under stress due to nutrient deprivation, hypoxia, trauma, or treatment with chemotherapy, among a variety of other causes. When released, DAMPs activate innate immunity, providing a pathway to a systemic inflammatory response in the absence of infection.
Brian A, Boone, Michael T, Lotze
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Damage-associated molecular patterns (DAMPS) in patients with advanced cancer undergoing systemic treatment.

Journal of Clinical Oncology, 2022
e14524 Background: Immunogenic cell death (ICD) is known for the release of DAMPS from tumor cells. We aimed to find signals of ICD by assessing the variation of plasma DAMPS (HMGB1 and S100A8) after vs. before standard of care (SoC) systemic treatment in patients with advanced solid tumors. Methods: Patients scheduled to start a new line of systemic
Vicente Valenti, Laia Capdevila, Isabel Ruiz, Joan Badia, Francisco Javier Ramos Pascual, Susana Blázquez, Óscar Villuendas, Cristina Pérez, Gemma Flores, Mónica Córdoba, Carlos Alonso   +10 more
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The role of damage associated molecular pattern molecules (DAMPs) and permeability of the blood-brain barrier in depression and neuroinflammation

Journal of Neuroimmunology, 2022
Depression is a heterogeneous mental disorder characterized by feelings of sadness and loss of interest that render the subject unable to handle basic daily activities such as sleeping, eating, or working. Neurobiological traits leading to depression include genetic background, early life abuse, life stressors, and systemic and central inflammatory ...
María Fernanda, Serna-Rodríguez, Sofía, Bernal-Vega, José Alfonso Ontiveros-Sánchez, de la Barquera, Alberto, Camacho-Morales, Antonio Alí, Pérez-Maya   +4 more
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Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox

Trends in Immunology, 2007
Immune responses are initiated and perpetuated by molecules derived from microorganisms pathogen-associated molecular-pattern molecules or from the damage or death of host cells [damage-associated molecular-pattern (DAMP) molecules]. Many DAMPs are nuclear or cytosolic proteins with defined intracellular function that, when released outside the cell ...
Anna, Rubartelli, Michael T, Lotze
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[DAMPs (damage-associated molecular patterns) and inflammation].

Nihon rinsho. Japanese journal of clinical medicine, 2016
Post-ischemic inflammation is re-appraised as an important player in the progression of ischemic stroke. Activation of inflammatory cells via Toll-like receptor 2 (TLR2) and TLR4 is caused by several damage-associated molecular patterns (DAMPs), including high mobility group box-1 (HMGB-1) and heat shock proteins.
Hiroaki, Ooboshi, Takashi, Shichita
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DAMPs: Damage-Associated Molecular Pattern Molecules in Hemostasis

2016
This chapter explores the role of some of the key DAMPs in modulating the coagulation and fibrinolytic cascades, how they activate platelets, and modulate platelet functions. Potential mechanisms differentiating disseminated intravascular coagulation from thrombosis are discussed with an emphasis on the generation of procoagulant membrane remnants that
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Role of Extracellular Damage-Associated Molecular Pattern Molecules (DAMPs) as Mediators of Persistent Pain

2015
Damage-associated molecular pattern molecules (DAMPs) are endogenous molecules that are constitutively expressed and released upon tissue damage, resulting in activation of the immune system. In the absence of injury or infection, DAMPs play important intracellular roles.
Jungo, Kato, Camilla I, Svensson
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Toll-Like Receptor 4 Activation by Damage-Associated Molecular Patterns (DAMPs)

2020
Mammalian toll-like receptors (TLRs) act as key sensors of pathogen-associated molecular patterns (PAMP), such as bacterial lipopolysaccharides (LPS), lipopeptides, and flagellin, which are molecular structures present in microbial cells but not in host cells.
Monica Molteni, Carlo Rossetti
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