Danger signals and graft-versus-host disease: Current understanding and future perspectives
Frontiers in Immunology, 2016 Graft-versus-host response after allogeneic hematopoietic stem cell transplantation (allo-HCT) represents one of the most intense inflammatory responses observed in humans.
Tomomi Toubai +3 more
doaj +1 more source
NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury
Nature Communications, 2017 Damage-associated molecular patterns (DAMP) are important mediators of innate immunity. Here the authors show that N-myc and STAT interactor (NMI) and interferon-induced protein 35 (IFP35) act as DAMPs to promote inflammation by activating macrophages ...
Zhikai Xiahou +10 more
doaj +1 more source
Cell death in the pathogenesis of immune-mediated diseases
Swiss Medical Weekly, 2011 Cell death is a ubiquitous process whose immunological consequences can influence the course of infectious, autoimmune and inflammatory diseases. While cell death has long been dichotomised in terms of apoptosis and necrosis, other forms of death ...
D Pisetsky
doaj +1 more source
Using PAMPs and DAMPs as adjuvants in cancer vaccines
Human Vaccines & Immunotherapeutics, 2021 Immunotherapy for cancer has attracted considerable attention. As one of the immunotherapeutics, tumor vaccines exert great potential for cancer immunotherapy.
Huanyou Sun +10 more
doaj +1 more source
The sensing of mitochondrial DAMPs by non-immune cells
Cell Stress, 2019 Mitochondria are the source of damage-associated molecular patterns (DAMPs), which are molecules that play a key modulatory role in immune cells. These molecules include proteins and peptides, such as N-formyl peptides and TFAM, as well as lipids, and ...
Aida Rodríguez-Nuevo, Antonio Zorzano
doaj +1 more source
A study of cell membranes in nasal epithelial cells from patients with chronic rhinosinusitis with nasal polyps by means of a fluorescent probe [PDF]
, 2009 Aim. To assess the state of membranes in nasal epithelial cells obtained from the patients with chronic rhinosinusitis with nasal polyps (CRSwNP) with the help of the fluorescent probe 2-(2ʹ-ОН-phenyl)-5-phenyl-1,3-oxazole. Methods. The state of membrane
Onishchenko, A. I. +6 more
core +1 more source
Immune and Inflammatory Pathways in Non-Alcoholic Steatohepatitis (NASH). An update [PDF]
, 2019 Non-alcoholic steatohepatitis (NASH), also known as fatty liver disease (FLD), is a major public health problem. It is considered to be the hepatic manifestation of the metabolic syndrome.
Breaban, Iulia +10 more
core +1 more source
Advances in Plant-Nematode Interactions with Emphasis on the Notorious Nematode Genus Meloidogyne. [PDF]
, 2019 Plant infections by plant-parasitic nematodes (PPNs) continue to be one of the major limitations in agricultural systems. Root-knot nematodes (RKNs), belonging to the genus Meloidogyne, are one of the most important groups of PPNs worldwide.
Kaloshian, Isgouhi, Teixeira, Marcella
core
The role of purine metabolites as DAMPs in acute graft-versus-host disease.
Frontiers in Immunology, 2016 Acute graft-versus-host disease (GVHD) causes high mortality in patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT). An early event in the classical pathogenesis of acute GVHD is tissue damage caused by the conditioning ...
Petya Apostolova, Robert Zeiser
doaj +1 more source
The Role of Mitochondrial Damage-Associated Molecular Patterns in Chronic Neuroinflammation
Mediators of Inflammation, 2019 Mitochondrial dysfunction has been established as a common feature of neurodegenerative disorders that contributes to disease pathology by causing impaired cellular energy production.
Ekta Bajwa +2 more
doaj +1 more source