Active Hydrophilic Components of the Medicinal Herb Salvia miltiorrhiza (Danshen) Potently Inhibit Organic Anion Transporters 1 (Slc22a6) and 3 (Slc22a8) [PDF]
, 2012 Many active components of herbal products are small organic anions, and organic anion transporters were previously demonstrated to be a potential site of drug-drug interactions.
Sweet, Douglas H., Wang, Li
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Food-Herb Dual-Function in Astragali Radix-Poria-Rheum: Network Pharmacology and Database Mining for Diabetic Kidney Disease Mechanisms Exploration. [PDF]
Food Sci NutrThis study identified the core food‐herb formula “Astragali Radix‐Poria‐Rheum (Ast‐Por‐Rhe)” for Diabetic Kidney Disease (DKD) through data mining of clinical prescriptions. Integrated network pharmacology and in vivo validation revealed that this formula ameliorates renal injury and insulin resistance in DKD rats by activating the IRS1/PI3K/AKT ...
Wang M +8 more
europepmc +2 more sources
Expression of P53 and Bcl2 Mammary Adenocarcinoma in C3H Mice Administered with Salvia Miltiorrhizae Bunge Root Extract [PDF]
, 2016 BackgroundBreast cancer is on the first or second most Malignancy in many places around the world. The incidence of breast cancer was increasing, also in Indonesia.
Dewi, L. S. (Liza) +2 more
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Discussion of astrocytic mitochondria as a therapeutic target for ischemic stroke
Journal of Hebei University of Science and Technology, 2021 Ischemic stroke is a common acute cerebrovascular disease in the middle-aged and elderly,and one of the most fatal diseases in the world.There are limited treatment options that currently exist and only apply to a small proportion of stroke patients,so ...
Xiaomei SU, Danshen ZHANG
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Salvia miltiorrhiza treatment during early reperfusion reduced postischemic myocardial injury in the rat [PDF]
, 2007 Oxidative stress may play a causative role in myocardial ischemia-reperfusion injury. However, it is a relatively understudied aspect regarding an optimal timing of antioxidant intervention during ischemia-reperfusion.
Nie, R, Xia, R, Xia, Z, Zhong, X
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Danshen protects against early-stage alcoholic liver disease in mice via inducing PPARα activation and subsequent 4-HNE degradation. [PDF]
PLoS ONE, 2017 Alcoholic liver disease (ALD) is a type of chronic liver disease caused by long-term heavy ethanol consumption. Danshen is one of the most commonly used substances in traditional Chinese medicine and has been widely used for the treatment of various ...
Lei Ding +5 more
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Biologia Plantarum, 2012 The enzyme 4-coumarate:coenzyme A ligase (4CL) plays an important role in phenylpropanoid metabolism. The 5'-upstream regions of two Sm4CL genes were isolated from danshen (Salvia miltiorrhiza Bunge) and their functions were characterized by promoter ...
X. Q. Jin +4 more
doaj +1 more source
Novel anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57 for prophylactic therapy [PDF]
, 2015 published_or_final_versio
Chong, CM +13 more
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Frontiers in Pharmacology, 2019 Danshen (salvia miltiorrhiza Bunge) is widely used in traditional Chinese medicine. However, it is definite clinical effort and mechanism on breast cancer is unclear.
Yu-Shih Lin +23 more
doaj +1 more source
World Journal of Traditional Chinese MedicineObjective: The objective of this study was to decipher chemical interactions between Danshen and Danggui using liquid chromatography–mass spectrometry (LC-MS) and explore the mechanisms of Danshen–Danggui against stroke using network pharmacology and ...
Han-Qing Pang +10 more
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