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Nocturnin is a Circadian-Regulated Deadenylase
2017A hallmark of circadian clock components is their rhythmic expression profile. Nocturnin, a rhythmically expressed gene, was first identified in the Xenopus laevis retina. Since then, nocturnin homologues have been identified in several other organisms, including mouse, where it is also expressed with a high amplitude circadian rhythmicity.
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The CCR4-NOT deadenylase activity contributes to generation of induced pluripotent stem cells
Biochemical and Biophysical Research Communications, 2016Somatic cells can be reprogrammed as induced pluripotent stem cells (iPSCs) by introduction of the transcription factors, OCT3/4, KLF4, SOX2, and c-MYC. The CCR4-NOT complex is the major deadenylase in eukaryotes. Its subunits Cnot1, Cnot2, and Cnot3 maintain pluripotency and self-renewal of mouse and human embryonic stem (ES) cells and contribute to ...
Ari Zukeran +6 more
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Novel interaction between CCR4 and CAF1 in rice CCR4–NOT deadenylase complex
Plant Molecular Biology, 2016Rice is an important crop in the world. However, little is known about rice mRNA deadenylation, which is an important regulation step of gene expression at the post-transcriptional level. The CCR4-NOT1 complex contains two key components, CCR4 and CAF1, which are the main cytoplasmic deadenylases in eukaryotic cells.
Wei-Lun, Chou +3 more
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MARTRE: the brake of CCR4-NOT deadenylase
SCIENTIA SINICA VitaeKunMing YAN, Hao YUN, Hong CHENG
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Structural and mechanistic insights into the S. pombe Pop2 deadenylase protein
2010Jonstrup, Anette Thyssen +3 more
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