Results 131 to 140 of about 3,926 (154)

Endothelial ADAR1 Deficit Induces the NOCT-IRF7 Axis in Pulmonary Hypertension. [PDF]

Circ Res
Woodcock CC, Maroli G, Kim H, Tai YY, Tang Y, Okawa S, Homsi R, Kim Y, Cho ST, Jiang S, Chauvet C, Wang B, Al Aaraj Y, Lafyatis R, Saggar R, Sembrat J, Wang Q, Li Q, Frump AL, Lahm T, McCubbrey AL, Kudryashova TV, Goncharova EA, Nouraie SM, Bertero T, Yuan K, Pullamsetti SS, Chan SY.   +27 more
europepmc   +1 more source

Plant P-bodies in post-transcriptional control: Composition, dynamics, and context-dependent roles. [PDF]

Plant Commun
Matinahmadi A, Zayani Z, Majewska K, Smoliński DJ.   +3 more
europepmc   +1 more source

RNA-binding proteins provide specificity to the PAN2–PAN3 mRNA deadenylation complex

Tang TT, Zangari F, Yu CW, Stowell JA, Roeselová A, Freund SM, Gingras A, Passmore LA.   +7 more
europepmc   +1 more source

Novel insights into the interaction between IGF2BPs and ncRNAs in cancers. [PDF]

Cancer Cell Int
Sun Y, Wu J, Sun W, Liu C, Shi X.
europepmc   +1 more source

GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets

Molecular Cell, 2011
miRNAs are posttranscriptional regulators of gene expression that associate with Argonaute and GW182 proteins to repress translation and/or promote mRNA degradation.
Elisa Izaurralde, Joerg E Braun, Eric Huntzinger   +2 more
exaly   +2 more sources

Molecular Basis for poly(A) RNP Architecture and Recognition by the Pan2-Pan3 Deadenylase [PDF]

Cell, 2019
The stability of eukaryotic mRNAs is dependent on a ribonucleoprotein (RNP) complex of poly(A)-binding proteins (PABPC1/Pab1) organized on the poly(A) tail.
Mike Strauss, Jan Michael Schuller, Elena Conti   +2 more
exaly   +2 more sources

The Transcription Factor Associated Ccr4 and Caf1 Proteins Are Components of the Major Cytoplasmic mRNA Deadenylase in Saccharomyces cerevisiae [PDF]

Cell, 2001
The major pathways of mRNA turnover in eukaryotes initiate with shortening of the poly(A) tail. We demonstrate by several criteria that CCR4 and CAF1 encode critical components of the major cytoplasmic deadenylase in yeast.
Clyde L Denis, Roy Parker, Junji Chen
exaly   +2 more sources

The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4–Not complex contribute to the prevention of cell death and senescence

Molecular Biology of the Cell, 2011
A key step in cytoplasmic mRNA degradation is the shortening of the poly(A) tail, which involves several deadenylase enzymes. Relatively little is known about the importance of these enzymes for the cellular physiology.
Akhmed Aslam, G Sebastiaan Winkler
exaly   +2 more sources

Structure of the PAN3 Pseudokinase Reveals the Basis for Interactions with the PAN2 Deadenylase and the GW182 Proteins

Molecular Cell, 2013
The PAN2-PAN3 deadenylase complex functions in general and miRNA-mediated mRNA degradation and is specifically recruited to miRNA targets by GW182/TNRC6 proteins.
Oliver Weichenrieder, Elisa Izaurralde, Mary Christie   +2 more
exaly   +2 more sources

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Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure

Cell Metabolism, 2022
Tim H-M Huang, Teppei Fujikawa, Ivan Topisirovic   +2 more
exaly