Results 121 to 130 of about 6,008 (204)

PABPN1 Couples the Polyadenylation and Translation of Maternal Transcripts to Mouse Oocyte Meiotic Maturation

Advanced Science, Volume 12, Issue 23, June 20, 2025.
This study reveals that cytoplasmic PABPN1 is essential for mouse oocyte meiotic maturation by coordinating polyadenylation, translation, and degradation of maternal mRNAs. Pabpn1 knockout disrupts CDK1 activation, spindle formation, and chromosome alignment by impairing maturation‐promoting factor (MPF) regulation and BTG4‐mediated deadenylation ...
Xing‐Xing Dai, Yu‐Ke Wu, Shuai‐Bo Pi, Feng‐Jie Hu, Yun‐Wen Wu, Hang Qi, Zhiyi Li, Zhi‐Yan Jiang, Long‐Wen Zhao, Heng‐Yu Fan   +9 more
wiley   +1 more source

The 5'-3' exoribonuclease Pacman (Xrn1) regulates expression of the heat shock protein Hsp67Bc and the microRNA miR-277-3p in Drosophila wing imaginal discs [PDF]

, 2013
Pacman/Xrn1 is a highly conserved exoribonuclease known to play a critical role in gene regulatory events such as control of mRNA stability, RNA interference and regulation via miRNAs.
Bate M, Carballo E, Christopher I Jones, Dominic P Grima, Hannah N Parker, Joseph A Waldron, Sarah F Newbury, Sue Jones   +7 more
core   +1 more source

Multispecies reconstructions uncover widespread conservation, and lineage-specific elaborations in eukaryotic mRNA metabolism. [PDF]

, 2018
The degree of conservation and evolution of cytoplasmic mRNA metabolism pathways across the eukaryotes remains incompletely resolved. In this study, we describe a comprehensive genome and transcriptome-wide analysis of proteins involved in mRNA ...
Bannerman, Bridget P, Carrington, Mark, Dorrell, Richard G, Kramer, Susanne   +3 more
core   +2 more sources

Specificity factors in cytoplasmic polyadenylation [PDF]

, 2013
Poly(A) tail elongation after export of an messenger RNA (mRNA) to the cytoplasm is called cytoplasmic polyadenylation. It was first discovered in oocytes and embryos, where it has roles in meiosis and development.
Afonina, Alarcon, Andres-Aguayo, Arumugam, Ascano, Aslam, Atkins, Atkins, Baines, Balagopal, Ballantyne, Bardwell, Barkoff, Barkoff, Barnard, Barnard, Bazzini, Belloc, Belloc, Benoit, Berger-Sweeney, Bermudez, Berndt, Bestman, Bestman, Bethune, Bilger, Bouvet, Bouvrette, Bouvrette, Brawerman, Brook, Brook, Burgess, Burgess, Burns, Burns, Bushell, Campbell, Campbell, Cao, Cao, Cao, Castagnetti, Cervello, Chan, Chang, Charlesworth, Charlesworth, Charlesworth, Charlesworth, Charlesworth, Chen, Chen, Chen, Cheng, Cheng, Chicoine, Choi, Clarke, Cogswell, Coll, Collier, Cooke, Costa, Craig, Darnell, Darnell, Dasgupta, De Moor, De Moor, Derry, Dettwiler, Di Giammartino, Dickson, Dickson, Didiot, Djuranovic, Du, Eckmann, Eckmann, Edwards, Eiring, Eliscovich, Ernoult-Lange, Ezeh, Fabian, Fan, Ferby, Fernandez-Miranda, Fox, Frank-Vaillant, Friend, Fu, Gavin, Gebauer, Gebauer, Gonzales, Gravina, Groisman, Groisman, Groisman, Groisman, Gunter, Guzeloglu-Kayisli, Guzeloglu-Kayisli, Hafer, Hake, Hake, Hodgman, Hoog, Hosoda, Hosoda, Houseley, Hu, Huang, Huang, Huang, Huarte, Hägele, Igea, Imai, Jenkins, Ji, Jin, Johnson, Jones, Juge, Kan, Kashiwabara, Kashiwabara, Kashiwabara, Katoh, Kaufmann, Kawahara, Keady, Keleman, Kerwitz, Kiessling, Kim, Kim, Kim, Kim, Kim, Kojima, Kolev, Kondrashov, Kosaka, Kraus, Kruttner, Kuehn, Kuehner, Kuhn, Kundel, Kuo, Kuo, Kwak, Kwak, Laishram, Laishram, Lee, Li, Lin, Lin, Luitjens, Lutz, Ma, Maisonneuve, Makeyev, Mandel, Martin, Martineau, Martinez, Martinson, Masuda, Maton, McEvoy, McGrew, McGrew, McPheeters, Meijer, Meijer, Meijer, Mellman, Mellman, Mendez, Mendez, Mendez, Menon, Millevoi, Moore, Moretti, Mukherjee, Nagaike, Nagaoka, Nairismagi, Nakahata, Nakahata, Nakahata, Nakanishi, Nakanishi, Nakel, Novoa, Okano, Oruganty-Das, Osborne, Ostareck-Lederer, Padmanabhan, Paffenholz, Paillard, Paillard, Papin, Paris, Paris, Pavlopoulos, Pederson, Peng, Piazzon, Pique, Preker, Proudfoot, Qu, Quenault, Racki, Radford, Rattenbacher, Reverte, Reverte, Reynolds, Roretz, Rouhana, Ryan, Rybarska, Sagata, Sagawa, Sakakibara, Sallés, Sasayama, Schmid, Schoenberg, Seli, Setoyama, Shcherbik, Sheets, Sheets, Shi, Shinojima, Si, Si, Si, Simon, Simon, Simon, Slevin, Soucek, Standart, Stebbins-Boaz, Suh, Suh, Suzuki, Takagaki, Takeda, Tan, Tay, Tay, Tay, Teplova, Theis, Tian, Todaro, Topalian, Tran, Tucker, Udagawa, van, Vardy, Vassalli, Vessey, Villalba, Vishnu, Vogler, Wang, Wang, Wang, Wang, Wang, Watanabe, Weill, Weiss, Wells, Wilt, Wiszniak, Wong, Wong, Wong, Wreden, Wu, Wu, Wu, Wu, Yang, Yang, Yang, Ye, Yen, Yeo, Zalfa, Zearfoss, Zeng, Zhao, Zhong, Zhuang   +311 more
core   +2 more sources

Codon choice directs constitutive mRNA levels in trypanosomes. [PDF]

, 2018
Selective transcription of individual protein coding genes does not occur in trypanosomes and the cellular copy number of each mRNA must be determined post-transcriptionally.
Carrington, Mark, de Freitas Nascimento, Janaina, Kelly, Steven, Sunter, Jack   +3 more
core   +2 more sources

The role of RNA Polymerase II-dependent transcription elongation in the cross-talk between mRNA synthesis and decay. [PDF]

, 2018
The main molecule in gene expression is messenger RNA (mRNA) which transfers the information contained in genes in the nucleus to the cytoplasm where it is translated into proteins that carry out cellular functions. mRNA levels are determined through its
Begley, Victoria Sarah
core  

piRNAs and Aubergine cooperate with Wispy poly(A) polymerase to stabilize mRNAs in the germ plasm [PDF]

, 2017
Piwi-interacting RNAs (piRNAs) and PIWI proteins play a crucial role in germ cells by repressing transposable elements and regulating gene expression. In Drosophila, maternal piRNAs are loaded into the embryo mostly bound to the PIWI protein Aubergine ...
Beilharz, Traude H., Bontonou, Gwénaëlle, Chartier, Aymeric, Dufourt, Jérémy, Harrison, Paul F., Jahan, Camille, Meunier, Anne Cecile, Papin, Catherine, Pierson, Stéphanie, Simonelig, Martine   +9 more
core   +4 more sources

Dynamic Control of Dendritic mRNA Expression by CNOT7 Regulates Synaptic Efficacy and Higher Cognitive Function

Cell Reports, 2017
Translation of mRNAs in dendrites mediates synaptic plasticity, the probable cellular basis of learning and memory. Coordination of translational inhibitory and stimulatory mechanisms, as well as dendritic transport of mRNA, is necessary to ensure proper
Rhonda L. McFleder, Fernanda Mansur, Joel D. Richter   +2 more
doaj   +1 more source

Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity

eLife, 2017
Histone H3 lysine 36 methylation (H3K36me) is thought to participate in a host of co-transcriptional regulatory events. To study the function of this residue independent from the enzymes that modify it, we used a ‘histone replacement’ system in ...
Michael P Meers, Telmo Henriques, Christopher A Lavender, Daniel J McKay, Brian D Strahl, Robert J Duronio, Karen Adelman, A Gregory Matera   +7 more
doaj   +1 more source

NOC out the fat: A short review of the circadian deadenylase Nocturnin

Annals of Medicine, 2008
The circadian clock is a conserved internal timekeeping mechanism that controls many aspects of physiology and behavior via the rhythmic expression of many genes. One of these rhythmic genes, Nocturnin, encodes a deadenylase--a ribonuclease that specifically removes the poly(A) tails from mRNAs.
Nicholas, Douris, Carla B, Green
openaire   +2 more sources