Results 111 to 120 of about 6,008 (204)

Comparison of reproducibility, accuracy, sensitivity, and specificity of miRNA quantification platforms [PDF]

, 2019
Given the increasing interest in their use as disease biomarkers, the establishment of reproducible, accurate, sensitive, and specific platforms for microRNA (miRNA) quantification in biofluids is of high priority.
Barczak, Andrea J, Das, Saumya, DeHoff, Peter, Erle, David J, Etheridge, Alton, Galas, David, Godoy, Paula M, Laurent, Louise C, Srinivasan, Srimeenakshi   +8 more
core   +1 more source

Migration of germline progenitor cells is directed by sphingosine-1-phosphate signalling in a basal chordate. [PDF]

, 2015
The colonial ascidian Botryllus schlosseri continuously regenerates entire bodies in an asexual budding process. The germ line of the newly developing bodies is derived from migrating germ cell precursors, but the signals governing this homing process ...
Bui, Connor, De Tomaso, Anthony W, Kassmer, Susannah H, Langenbacher, Adam D, Rodriguez, Delany   +4 more
core   +1 more source

Plasmodium male gametocyte development and transmission are critically regulated by the two putative deadenylases of the CAF1/CCR4/NOT complex.

PLoS Pathogens, 2019
With relatively few known specific transcription factors to control the abundance of specific mRNAs, Plasmodium parasites may rely more on the regulation of transcript stability and turnover to provide sufficient gene regulation.
Kevin J Hart, Jenna Oberstaller, Michael P Walker, Allen M Minns, Mark F Kennedy, Ian Padykula, John H Adams, Scott E Lindner   +7 more
doaj   +1 more source

Tetramerisation of the CRISPR ring nuclease Crn3/Csx3 facilitates cyclic oligoadenylate cleavage

eLife, 2020
Type III CRISPR systems detect foreign RNA and activate the cyclase domain of the Cas10 subunit, generating cyclic oligoadenylate (cOA) molecules that act as a second messenger to signal infection, activating nucleases that degrade the nucleic acid of ...
Januka S Athukoralage, Stuart McQuarrie, Sabine Grüschow, Shirley Graham, Tracey M Gloster, Malcolm F White   +5 more
doaj   +1 more source

Role of CPEBs in Learning and Memory

Journal of Neurochemistry, Volume 169, Issue 9, September 2025.
SUMOylation of CPEB3 and its association with target mRNA can lead to phase separation and localisation to P bodies, where translation of target mRNAs is repressed. (1) Activation of AMPA and NMDA receptors leads to (2) long‐term potentiation (LTP). Increased cellular Ca2+ concentration leads to activation of calpain‐2 and some proteolysis of CPEB3. (3)
David A. Hicks, Liam D. Aubrey, Jessica C. F. Kwok, Sheena E. Radford   +3 more
wiley   +1 more source

Identification of novel post-transcriptional features in olfactory receptor family mRNAs. [PDF]

, 2015
Olfactory receptor (Olfr) genes comprise the largest gene family in mice. Despite their importance in olfaction, how most Olfr mRNAs are regulated remains unexplored.
Espinoza, Josh L, Ramaiah, Madhuvanthi, Shum, Eleen Y, Wilkinson, Miles F   +3 more
core   +1 more source

RNA‐binding proteins orchestrating immunity in plants

The Plant Journal, Volume 123, Issue 5, September 2025.
SUMMARY RNA‐binding proteins (RBPs) direct the function and fate of RNA throughout the RNA lifecycle and play important roles in plant immunity, orchestrating the post‐transcriptional reprogramming of the transcriptome following induction of plant immune responses, a process that we term ‘RBP‐mediated immunity’. Although the importance of specific RBPs
Marcel Bach‐Pages, Athira Menon, Brett Wadley, Alfredo Castello, Gail M. Preston   +4 more
wiley   +1 more source

Cleavage of 3′-terminal adenosine by archaeal ATP-dependent RNA ligase [PDF]

, 2017
Methanothermobacter thermoautotrophicus RNA ligase (MthRnl) catalyzes formation of phosphodiester bonds between the 5′-phosphate and 3′-hydroxyl termini of single-stranded RNAs.
Gollnick Paul, Ho C. Kiong, Liu Yancheng, Yoshinari Shigeo   +3 more
core   +3 more sources

Mechanisms governing poly(A)-tail-length specificity of the human PAN2-PAN3 deadenylase complex

Cell Reports
Summary: The lifespan of most eukaryotic mRNAs is modulated by the gradual shortening of the poly(A) tail and removal of the associated poly(A)-binding protein.
Jana C. Albrecht, Timo Reitinger, Jérôme Basquin, Steffen Schüssler, Margot Riggi, Ingmar B. Schäfer, Elena Conti   +6 more
doaj   +1 more source

Insights into the structure and architecture of the CCR4-NOT complex

Frontiers in Genetics, 2014
The CCR4-NOT complex is a highly conserved, multifunctional machinery with a general role in controlling mRNA metabolism. It has been implicated in a number of different aspects of mRNA and protein expression, including mRNA degradation, transcription ...
Kun eXu, Yuwei eBai, Aili eZhang, Qionglin eZhang, Mark Gerrard Bartlam   +4 more
doaj   +1 more source