Results 91 to 100 of about 3,926 (154)

CAF1-knockout mice are more susceptive to lipopolysaccharide-induced acute lung injury

Journal of Inflammation Research, 2016
Jia-Xin Shi,1 Jia-Shu Li,1 Rong Hu,1 Xiao-Min Li,2 Hong Wang3 1Department of Respiratory Medicine, Lianyungang First People’s Hospital, Affiliated Hospital of Xuzhou Medical University, Affiliated Hospital of the Clinical Medical School of Nanjing ...
Shi JX, Li JS, Hu R, Li XM, Wang H
doaj  

The structure of the Pan2-Pan3 core complex reveals cross-talk between deadenylase and pseudokinase

, 2014
Pan2-Pan3 is a conserved complex involved in the shortening of mRNA poly(A) tails, the initial step in eukaryotic mRNA turnover. We show that recombinant Saccharomyces cerevisiae Pan2-Pan3 can deadenylate RNAs in vitro without needing the poly(A)-binding
Fabien Bonneau, Conti, E., Elena Conti, Schäfer, I., Michaela Rode, Steffen Schüssler, Schüssler, S., Ingmar B Schäfer, Rode, M., Bonneau, F.   +9 more
core   +1 more source

The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes

, 2012
GW182 family proteins are essential for miRNA-mediated gene silencing in animal cells. They are recruited to miRNA targets via interactions with Argonaute proteins and then promote translational repression and degradation of the miRNA targets.
Schmidt, S., Izaurralde, E., Izaurralde, Elisa, Schmidt, Steffen, Huntzinger, E., Kuzuoğlu-Öztürk, D., Kuzuoğlu-Öztürk, Duygu, Huntzinger, Eric   +7 more
core   +1 more source

The Ccr4-Not deadenylase complex constitutes the main poly(A) removal activity in C. elegans.

, 2013
Post-transcriptional regulatory mechanisms are widely used to control gene expression programs of tissue development and physiology. Controlled 3' poly(A) tail-length changes of mRNAs provide a mechanistic basis of such regulation, affecting mRNA ...
Millonigg, S., Nousch, M., Eckmann, C., Techritz, N., Hampel, D.   +4 more
core  

Pontocerebellar hypoplasia linked mutations of the deadenylase Target of EGR1 (TOE1) impair thermal stability, ribonuclease activity, and oligomerization. [PDF]

J Biol Chem
Zavala L, Sobien M, Hayne CK.
europepmc   +1 more source

PUF family RNA-binding proteins Puf1 and Puf2 promote transcript degradation in Toxoplasma gondii. [PDF]

J Biol Chem
Khandavalli CR, Gurupwar R, Deshmukh AS.
europepmc   +1 more source

ZFP36 Family Proteins as Critical Regulators of Inflammation, Immune Cell Development, and Antiviral Responses. [PDF]

Vaccines (Basel)
Bhowmik M, Momin T, Thakur N, Singh N, Rajput M.   +4 more
europepmc   +1 more source

Poly(A) tail regulation in stem cells and early development. [PDF]

Cell Regen
Miao X, Hu G.
europepmc   +1 more source

The SPN-4 Rbfox RNA-binding protein selects maternal mRNAs for CCR4-NOT-dependent clearance in early Caenorhabditis elegans embryos. [PDF]

Development
Spike CA, Parker DM, Tsukamoto T, Torres Mangual N, Tsukamoto EC, Coleman K, Gearhart MD, Greenstein D, Osborne Nishimura E.   +8 more
europepmc   +1 more source

Enhancing mRNA stability and translational potential through tailored modifications at the 3' end. [PDF]

RSC Chem Biol
Perzanowska O, Kowalska J, Jemielity J.
europepmc   +1 more source