Results 91 to 100 of about 6,008 (204)

Targeting the lactylation of ENO1 alleviates endothelial dysfunction in sepsis

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Lactylation of ENO1 reduced the binding of TRIM21 mRNA to ENO1, thereby preventing mRNA degradation. Elevated TRIM21 subsequently binds to VE‐Cadherin, promoting its ubiquitination. Targeting the lactylation of ENO1 with a specific inhibitory peptide alleviated endothelial dysfunction.
Xueru Xie, Tingyan Liu, Caiyan Zhang, Ye Cheng, Yajing Gao, Wenfeng Xiao, Haiyan Guo, Yutong Zhou, Yawei Yu, Kexin Wang, Yinghong Lin, Lisheng Xiao, Yingying Zhang, Weiguo Yang, Gangfeng Yan, Guoping Lu, Yufeng Zhou   +16 more
wiley   +1 more source

RrmA regulates the stability of specific transcripts in response to both nitrogen source and oxidative stress [PDF]

, 2013
Differential regulation of transcript stability is an effective means by which an organism can modulate gene expression. A well-characterized example is glutamine signalled degradation of specific transcripts in Aspergillus nidulans. In the case of areA,
Caddick, M.X., Dzikowska, A., Jones, M.G., Krol, K., Morozov, Igor, Weglenski, P., Wyszomirski, T.   +6 more
core   +2 more sources

LOTUS domain protein MARF1 binds CCR4-NOT deadenylase complex to post-transcriptionally regulate gene expression in oocytes

Nature Communications, 2018
The RNA-binding protein MARF1 is required for post-transcriptional regulation of mRNAs during mouse oogenesis. Here, by analyzing a Drosophila MARF1 mutant, the authors show that MARF1 recruits CCR4-NOT deadenylase to shorten the poly-A tails of target ...
Li Zhu, Suresh K. Kandasamy, Susan E. Liao, Ryuya Fukunaga   +3 more
doaj   +1 more source

From the Understanding of Maternal Molecules and Mechanisms to Predicting Embryonic Development

Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.
ABSTRACT Background Embryo quality is a critical determinant of successful outcomes in assisted reproductive technology (ART). Various molecular and cellular mechanisms in oocytes influence embryo quality, and their understanding can lead to the establishment of selection criteria for enhancing implantation rates. Methods This review summarizes current
Yubao Wei, Akihiro Inoue, Kei Miyamoto
wiley   +1 more source

Cell cycle RNA regulons coordinating early lymphocyte development [PDF]

, 2017
Lymphocytes undergo dynamic changes in gene expression as they develop from progenitor cells lacking antigen receptors, to mature cells that are prepared to mount immune responses.
Abdelmohsen, Achsel, Al-Haj, Bayeva, Bell, Bellavia, Benjamin, Blackinton, Blackinton, Brooks, Chen, Chen, Ciais, Ciofani, Clark, DeMicco, DeMicco, Diaz-Munoz, Fabian, Fallahi, Fuxa, Galloway, Gerstberger, Ghosh, Gruber, Gunzburg, Guo, Hacker, Haks, Halees, Hausburg, Heng, Herranz, Higashi, Hitti, Hodson, Horner, Inoue, Johnson, Keene, Kelly, Khabar, Kim, Kotta-Loizou, Kratochvill, Kreslavsky, Kullmann, Laurenti, Lu, Ma, Masamha, Meisner, Mijuskovic, Miskimins, Montorsi, Mukherjee, Mukherjee, Mukherjee, Muralidharan, Ochiai, Pang, Papadaki, Papaemmanuil, Patial, Pedraza-Alva, Raghavan, Rodriguez, Ross, Rounbehler, Sandler, Sanduja, Schmidlin, Sedlyarov, Selmi, Sinha, Spencer, Stoecklin, Stubbington, Stumpo, Stumpo, Techasintana, Thompson, Tiedje, Tiedje, Trigueros, Vigo, Vogel, Wang, Wei, Yang, Yao, Yasuda, Zhang, Zou, Zuniga-Pflucker   +94 more
core   +2 more sources

The PARN deadenylase targets a discrete set of mRNAs for decay and regulates cell motility in mouse myoblasts.

PLoS Genetics, 2012
PARN is one of several deadenylase enzymes present in mammalian cells, and as such the contribution it makes to the regulation of gene expression is unclear.
Jerome E Lee, Ju Youn Lee, Jarrett Trembly, Jeffrey Wilusz, Bin Tian, Carol J Wilusz   +5 more
doaj   +1 more source

RNF219 RING Finger Domain Mutants Drive Phase Separation to Encapsulate CCR4‐NOT and Promote Cell Proliferation

Cell Proliferation, Volume 59, Issue 1, January 2026.
Mutations in the RING finger domain (C3HC4) of RNF219 promote the formation of RNF219 condensates, which are able to encapsulate the CCR4‐NOT complex. These RNF219Mut‐CCR4‐NOT condensates reduce the deacetylation activity of the CCR4‐NOT complex and induce cell proliferation.
Chen Chen, Chenghao Guo, Ke Fang, Chengqi Lin, Zhuojuan Luo   +4 more
wiley   +1 more source

Identification of ebs1, lsm6 and nup159 as suppressors of spt10 effects at ADH2 in Saccharomyces cerevisiae suggests post-transcriptional defects affect mRNA synthesis [PDF]

, 2012
Suppression of the effects of an spt10 mutation on ADH2 expression is a phenotype shared by a small number of genes whose protein products are either components of the CCR4-NOT complex required for mRNA deadenylation and degradation (CCR4, CAF1, NOT4) or
Anderson, Bradley, Denis, Clyde L., May, Carrie Ann   +2 more
core   +3 more sources

Structural basis for inhibition of the deadenylase activity of human CNOT6L [PDF]

FEBS Letters, 2016
Human CNOT6L/CCR4, a member of the endonuclease‐exonuclease‐phosphatase (EEP) family enzymes, is one of the two deadenylase enzymes in the conserved CCR4‐NOT complex. Here, we report inhibitor‐bound crystal structures of the human CNOT6L nuclease domain in complex with the nucleotide CMP and the aminoglycoside neomycin. Deadenylase activity assays show
Qionglin Zhang, Dongke Yan, Erhong Guo, Bojian Ding, Wen Yang, Ruihua Liu, Tadashi Yamamoto, Mark Bartlam   +7 more
openaire   +2 more sources

Translational control in plants: from basic mechanisms to environmental and developmental responses

The Plant Journal, Volume 125, Issue 1, January 2026.
SUMMARY Protein synthesis is an essential process for all living organisms and is tightly regulated to ensure the proper production of proteins needed for growth, development, and stress responses. As sessile organisms, plants have evolved distinct mechanisms to regulate translation, allowing them to adapt to their environment.
Jade Lyons, Catharina Merchante, Anna N. Stepanova, Jose M. Alonso   +3 more
wiley   +1 more source