Results 91 to 100 of about 3,192 (173)
Mechanisms governing poly(A)-tail-length specificity of the human PAN2-PAN3 deadenylase complex
Cell ReportsSummary: The lifespan of most eukaryotic mRNAs is modulated by the gradual shortening of the poly(A) tail and removal of the associated poly(A)-binding protein.
Jana C. Albrecht +6 more
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Insights into the structure and architecture of the CCR4-NOT complex
Frontiers in Genetics, 2014 The CCR4-NOT complex is a highly conserved, multifunctional machinery with a general role in controlling mRNA metabolism. It has been implicated in a number of different aspects of mRNA and protein expression, including mRNA degradation, transcription ...
Kun eXu +4 more
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Cell Reports, 2017 Translation of mRNAs in dendrites mediates synaptic plasticity, the probable cellular basis of learning and memory. Coordination of translational inhibitory and stimulatory mechanisms, as well as dendritic transport of mRNA, is necessary to ensure proper
Rhonda L. McFleder +2 more
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PLoS Genetics, 2016 Accumulating evidence supports the role of an aberrant transcriptome as a driver of metastatic potential. Deadenylation is a general regulatory node for post-transcriptional control by microRNAs and other determinants of RNA stability.
Farhoud Faraji +6 more
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eLife, 2017 Histone H3 lysine 36 methylation (H3K36me) is thought to participate in a host of co-transcriptional regulatory events. To study the function of this residue independent from the enzymes that modify it, we used a ‘histone replacement’ system in ...
Michael P Meers +7 more
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CAF1-knockout mice are more susceptive to lipopolysaccharide-induced acute lung injury
Journal of Inflammation Research, 2016 Jia-Xin Shi,1 Jia-Shu Li,1 Rong Hu,1 Xiao-Min Li,2 Hong Wang3 1Department of Respiratory Medicine, Lianyungang First People’s Hospital, Affiliated Hospital of Xuzhou Medical University, Affiliated Hospital of the Clinical Medical School of Nanjing ...
Shi JX, Li JS, Hu R, Li XM, Wang H
doaj
Nocturnin, a Deadenylase in Xenopus laevis Retina [PDF]
Current Biology, 2003 Baggs, Julie E, Green, Carla B
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Structural and Biochemical Investigation of the Pan2-Pan3 Deadenylase Complex
, 2020 Almost all mature eukaryotic mRNAs contain a 3′ polyadenosine (poly(A)) tail, which promotes nuclear export of mRNAs, protects transcripts from exonucleolytic decay, and increases translation efficiency. As the poly(A) tail is involved in many steps of gene expression, its length is highly regulated.
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Mechanisms of mRNA substrate-selection by the Ccr4-Not deadenylase complex
, 2017 The level to which genes are expressed depends on the rate at which the mRNA is generated, and the rate at which it is utilised and destroyed. Almost all eukaryotic mRNAs contain a stretch of adenosine nucleotides known as the poly(A) tail. The removal of the polyA tail from an mRNA, a process called deadenylation, is an important mechanism of gene ...
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The SPN-4 Rbfox RNA-binding protein selects maternal mRNAs for CCR4-NOT-dependent clearance in early Caenorhabditis elegans embryos. [PDF]
DevelopmentSpike CA +8 more
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