Results 81 to 90 of about 3,926 (154)

CCR4, a 3 \u27-5 \u27 poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase [PDF]

, 2002
The CCR4-NOT complex from Saccharomyces cerevis iae is a general transcriptional regulatory complex. The proteins of this complex are involved in several aspects of mRNA metabolism, including transcription initiation and elongation and mRNA degradation ...
Chiang, Yueh-Chin, Yueh-Chin Chiang, Chen, Junji, Denis, Clyde L., Junji Chen, Clyde L. Denis   +5 more
core   +1 more source

Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment [PDF]

, 2017
The zinc-finger protein tristetraprolin (TTP) binds to AU-rich elements present in the 3′ untranslated regions of transcripts that mainly encode proteins of the inflammatory response.
Gileadi, O., Filippakopoulos, P, N.A. Burgess-Brown, R. Chalk, O. Fedorov, Chalk, Rod, Filippakopoulos, P., P. Mahajan, Bulbrook, D., Chalk, R, M. Kliszczak, C. Strain-Damerell, Mahajan, P., Burgess-Brown, Nicola, Picaud, S., Yue, WW, O. Gileadi, Fedorov, O, Burgess-Brown, N. A., Dean, J. L. E., Strain-Damerell, C., Marchese, FP, Fedorov, O., Kliszczak, M., Strain-Damerell, C, Brazier, H, W.W. Yue, Marchese, F. P., A. Aubareda, Gileadi, O, Fedorov, Oleg, Aubareda, A., D. Bulbrook, F.P. Marchese, A.R. Clark, Bulbrook, D, Aubareda, A, H. Brazier, Yue, W.w., Chalk, R., S. Picaud, Brazier, H., P. Filippakopoulos, Dean, JLE, Clark, A. R., Burgess-Brown, NA, Picaud, S, Clark, AR, Mahajan, P, Yue, Wyatt, Kliszczak, M, J.L.E. Dean   +51 more
core   +1 more source

Dynamic Control of Dendritic mRNA Expression by CNOT7 Regulates Synaptic Efficacy and Higher Cognitive Function

Cell Reports, 2017
Translation of mRNAs in dendrites mediates synaptic plasticity, the probable cellular basis of learning and memory. Coordination of translational inhibitory and stimulatory mechanisms, as well as dendritic transport of mRNA, is necessary to ensure proper
Rhonda L. McFleder, Fernanda Mansur, Joel D. Richter   +2 more
doaj   +1 more source

Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7.

PLoS Genetics, 2016
Accumulating evidence supports the role of an aberrant transcriptome as a driver of metastatic potential. Deadenylation is a general regulatory node for post-transcriptional control by microRNAs and other determinants of RNA stability.
Farhoud Faraji, Ying Hu, Howard H Yang, Maxwell P Lee, G Sebastian Winkler, Markus Hafner, Kent W Hunter   +6 more
doaj   +1 more source

Smaug Recruits the CCR4/POP2/NOT Deadenylase Complex to Trigger Maternal Transcript Localization in the Early Drosophila Embryo [PDF]

, 2005
Background: Asymmetric localization of mRNAs within cells promotes precise spatio-temporal control of protein synthesis. Although cytoskeletal transport-based localization during Drosophila oogenesis is well characterized, little is known about the ...
Semotok, Jennifer L., Smibert, Craig A., Cooperstock, Ramona L., Vari, Heli K., Pinder, Benjamin D., Lipshitz, Howard D.   +5 more
core   +1 more source

Alterations of Deadenylase Expression in Acute Leukemias: Evidence for Poly(A)-Specific Ribonuclease as a Potential Biomarker

, 2012
Background/Aims: The degradation of mRNA is a key process in the control of gene expression correlated to anomalous cell proliferation. The rate-limiting step of mRNA degradation is the removal of the poly(A) tail by deadenylases.
Karangeli, M., Papaspyrou, K., Labrou, M., Pournaras, S., Dimoulou, G., Matsouka, P., Gourgoulianis, K. I., Salataj, E., Balatsos, N. A. A., Maragozidis, P.   +9 more
core   +1 more source

Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity

eLife, 2017
Histone H3 lysine 36 methylation (H3K36me) is thought to participate in a host of co-transcriptional regulatory events. To study the function of this residue independent from the enzymes that modify it, we used a ‘histone replacement’ system in ...
Michael P Meers, Telmo Henriques, Christopher A Lavender, Daniel J McKay, Brian D Strahl, Robert J Duronio, Karen Adelman, A Gregory Matera   +7 more
doaj   +1 more source

Regulation of CCR4-NOT complex deadenylase activity and cellular responses by MK2-dependent phosphorylation of CNOT2 [PDF]

CCR4-NOT complex-mediated mRNA deadenylation serves critical functions in multiple biological processes, yet how this activity is regulated is not fully understood.
Tomohiro, Takumi, Fujiwara, Toshinobu, Nishijima, Saori, Hoshina, Naosuke, Yamamoto, Tadashi, Hoshina, Miyuki, Kikuguchi, Chisato, Suzuki, Toru, Fukao, Akira   +8 more
core   +1 more source

Importance of CNOT8 Deadenylase Subunit in DNA Damage Responses Following Ionizing Radiation (IR)

, 2020
Background: The Ccr4-Not protein complex (CNOT complex) is a key regulator of gene expression in eukaryotic cells. Ccr4-Not Complex is composed of at least nine conserved subunits in mammalian cells with two main enzymatic activities.
Eskandarian, S., Saeedi, M., Irani, S., Mirfakhraie, R., Grand, R.   +4 more
core  

MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment.

, 2010
Tristetraprolin (TTP) directs its target AU-rich element (ARE)-containing mRNAs for degradation by promoting removal of the poly(A) tail. The p38 MAPK pathway regulates mRNA stability via the downstream kinase MAPK-activated protein kinase 2 (MAPKAP ...
Marchese, FP, Corina Tudor, Saklatvala, J, Saklatvala, Jeremy, Tudor, Corina, Dean, JL, Jonathan L.E. Dean, Dean, Jonathan L.E., Francesco P. Marchese, Anna Aubareda, Aubareda, Anna, Clark, AR, Marchese, Francesco P., Andrew R. Clark, Clark, Andrew R., Tudor, C, Jeremy Saklatvala, Aubareda, A   +17 more
core   +1 more source