Results 81 to 90 of about 3,192 (173)

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

CNOT1 regulates circadian behaviour through Per2 mRNA decay in a deadenylation-dependent manner

RNA Biology, 2022
Circadian clocks are an endogenous internal timekeeping mechanism that drives the rhythmic expression of genes, controlling the 24 h oscillatory pattern in behaviour and physiology.
Haytham Mohamed Aly Mohamed, Akinori Takahashi, Saori Nishijima, Shungo Adachi, Iori Murai, Hitoshi Okamura, Tadashi Yamamoto   +6 more
doaj   +1 more source

The Circadian Transcription Factor CLOCK Modulates Oxidative Stress Resistance via the ACHL–Relish Axis in Drosophila

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study identifies the circadian transcription factor CLOCK (CLK) as a key regulator of oxidative stress resistance in fruit flies. CLK controls immune responses by driving rhythmic transcription of an RNA‐binding protein‐Achilles (ACHL) in the fly brain, which post‐transcriptionally represses the NF‐κB homolog Relish, limiting immune activation and
Xu Liu, Jiajia Fang, Dawei Cheng, Wei Luan, Yan Lv, Wen Hu, Lei Pan, Yong Zhang   +7 more
wiley   +1 more source

Targeting the lactylation of ENO1 alleviates endothelial dysfunction in sepsis

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Lactylation of ENO1 reduced the binding of TRIM21 mRNA to ENO1, thereby preventing mRNA degradation. Elevated TRIM21 subsequently binds to VE‐Cadherin, promoting its ubiquitination. Targeting the lactylation of ENO1 with a specific inhibitory peptide alleviated endothelial dysfunction.
Xueru Xie, Tingyan Liu, Caiyan Zhang, Ye Cheng, Yajing Gao, Wenfeng Xiao, Haiyan Guo, Yutong Zhou, Yawei Yu, Kexin Wang, Yinghong Lin, Lisheng Xiao, Yingying Zhang, Weiguo Yang, Gangfeng Yan, Guoping Lu, Yufeng Zhou   +16 more
wiley   +1 more source

From the Understanding of Maternal Molecules and Mechanisms to Predicting Embryonic Development

Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.
ABSTRACT Background Embryo quality is a critical determinant of successful outcomes in assisted reproductive technology (ART). Various molecular and cellular mechanisms in oocytes influence embryo quality, and their understanding can lead to the establishment of selection criteria for enhancing implantation rates. Methods This review summarizes current
Yubao Wei, Akihiro Inoue, Kei Miyamoto
wiley   +1 more source

RNF219 RING Finger Domain Mutants Drive Phase Separation to Encapsulate CCR4‐NOT and Promote Cell Proliferation

Cell Proliferation, Volume 59, Issue 1, January 2026.
Mutations in the RING finger domain (C3HC4) of RNF219 promote the formation of RNF219 condensates, which are able to encapsulate the CCR4‐NOT complex. These RNF219Mut‐CCR4‐NOT condensates reduce the deacetylation activity of the CCR4‐NOT complex and induce cell proliferation.
Chen Chen, Chenghao Guo, Ke Fang, Chengqi Lin, Zhuojuan Luo   +4 more
wiley   +1 more source

Plasmodium male gametocyte development and transmission are critically regulated by the two putative deadenylases of the CAF1/CCR4/NOT complex.

PLoS Pathogens, 2019
With relatively few known specific transcription factors to control the abundance of specific mRNAs, Plasmodium parasites may rely more on the regulation of transcript stability and turnover to provide sufficient gene regulation.
Kevin J Hart, Jenna Oberstaller, Michael P Walker, Allen M Minns, Mark F Kennedy, Ian Padykula, John H Adams, Scott E Lindner   +7 more
doaj   +1 more source

Tetramerisation of the CRISPR ring nuclease Crn3/Csx3 facilitates cyclic oligoadenylate cleavage

eLife, 2020
Type III CRISPR systems detect foreign RNA and activate the cyclase domain of the Cas10 subunit, generating cyclic oligoadenylate (cOA) molecules that act as a second messenger to signal infection, activating nucleases that degrade the nucleic acid of ...
Januka S Athukoralage, Stuart McQuarrie, Sabine Grüschow, Shirley Graham, Tracey M Gloster, Malcolm F White   +5 more
doaj   +1 more source

Translational control in plants: from basic mechanisms to environmental and developmental responses

The Plant Journal, Volume 125, Issue 1, January 2026.
SUMMARY Protein synthesis is an essential process for all living organisms and is tightly regulated to ensure the proper production of proteins needed for growth, development, and stress responses. As sessile organisms, plants have evolved distinct mechanisms to regulate translation, allowing them to adapt to their environment.
Jade Lyons, Catharina Merchante, Anna N. Stepanova, Jose M. Alonso   +3 more
wiley   +1 more source

Cellular Coordination of Transcription Factors and Regulatory Genes for Cryptococcal Virulence

Cellular Microbiology, Volume 2026, Issue 1, 2026.
Cryptococcus neoformans is an opportunistic pathogen belonging to the family Cryptococcaceae, capable of causing systemic and invasive fungal infections in humans and animals. The infection caused by Cryptococcus is lethal primarily in immunocompromised individuals due to the overwhelming expression of virulence factors that drive cryptococcosis in ...
Olufemi S. Folorunso, Olihile M. Sebolai, Sanket Kaushik   +2 more
wiley   +1 more source