Results 71 to 80 of about 3,926 (154)

The CCR4–NOT Deadenylase Complex Maintains Adipocyte Identity [PDF]

, 2019
Shortening of poly(A) tails triggers mRNA degradation; hence, mRNA deadenylation regulates many biological events. In the present study, we generated mice lacking the Cnot1 gene, which encodes an essential scaffold subunit of the CCR4–NOT deadenylase ...
Takahashi, Akinori, Kuba, Keiji, Yamamoto, Tadashi, Takaoka, Shohei, Kobori, Shungo, Yamaguchi, Tomokazu, Ferwati, Sara, Suzuki, Toru   +7 more
core   +2 more sources

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Xuan Yin, Zengkan Du, Shuya Jiang, Yan Liao, Changli Wang, Jiaqi Li, Haoling Zhang, Ting‐Ting Wei, Wangzheqi Zhang, Zui Zou   +9 more
wiley   +1 more source

Plasmodium male gametocyte development and transmission are critically regulated by the two putative deadenylases of the CAF1/CCR4/NOT complex.

PLoS Pathogens, 2019
With relatively few known specific transcription factors to control the abundance of specific mRNAs, Plasmodium parasites may rely more on the regulation of transcript stability and turnover to provide sufficient gene regulation.
Kevin J Hart, Jenna Oberstaller, Michael P Walker, Allen M Minns, Mark F Kennedy, Ian Padykula, John H Adams, Scott E Lindner   +7 more
doaj   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Tetramerisation of the CRISPR ring nuclease Crn3/Csx3 facilitates cyclic oligoadenylate cleavage

eLife, 2020
Type III CRISPR systems detect foreign RNA and activate the cyclase domain of the Cas10 subunit, generating cyclic oligoadenylate (cOA) molecules that act as a second messenger to signal infection, activating nucleases that degrade the nucleic acid of ...
Januka S Athukoralage, Stuart McQuarrie, Sabine Grüschow, Shirley Graham, Tracey M Gloster, Malcolm F White   +5 more
doaj   +1 more source

The Circadian Transcription Factor CLOCK Modulates Oxidative Stress Resistance via the ACHL–Relish Axis in Drosophila

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study identifies the circadian transcription factor CLOCK (CLK) as a key regulator of oxidative stress resistance in fruit flies. CLK controls immune responses by driving rhythmic transcription of an RNA‐binding protein‐Achilles (ACHL) in the fly brain, which post‐transcriptionally represses the NF‐κB homolog Relish, limiting immune activation and
Xu Liu, Jiajia Fang, Dawei Cheng, Wei Luan, Yan Lv, Wen Hu, Lei Pan, Yong Zhang   +7 more
wiley   +1 more source

Targeting the lactylation of ENO1 alleviates endothelial dysfunction in sepsis

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Lactylation of ENO1 reduced the binding of TRIM21 mRNA to ENO1, thereby preventing mRNA degradation. Elevated TRIM21 subsequently binds to VE‐Cadherin, promoting its ubiquitination. Targeting the lactylation of ENO1 with a specific inhibitory peptide alleviated endothelial dysfunction.
Xueru Xie, Tingyan Liu, Caiyan Zhang, Ye Cheng, Yajing Gao, Wenfeng Xiao, Haiyan Guo, Yutong Zhou, Yawei Yu, Kexin Wang, Yinghong Lin, Lisheng Xiao, Yingying Zhang, Weiguo Yang, Gangfeng Yan, Guoping Lu, Yufeng Zhou   +16 more
wiley   +1 more source

Insights into the structure and architecture of the CCR4-NOT complex

Frontiers in Genetics, 2014
The CCR4-NOT complex is a highly conserved, multifunctional machinery with a general role in controlling mRNA metabolism. It has been implicated in a number of different aspects of mRNA and protein expression, including mRNA degradation, transcription ...
Kun eXu, Yuwei eBai, Aili eZhang, Qionglin eZhang, Mark Gerrard Bartlam   +4 more
doaj   +1 more source

Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome

, 2021
Pumilio paralogs, PUM1 and PUM2, are sequence-specific RNA-binding proteins that are essential for vertebrate development and neurological functions. PUM1&2 negatively regulate gene expression by accelerating degradation of specific mRNAs.
Chang, C., Bohn, J., Levdansky, Y., Enwerem, I., Elrod, N., Ji, P., Goldstrohm, A., Wagner, E., Lin, A., Valkov, E.   +9 more
core   +1 more source

PARN deadenylase is involved in miRNA-dependent degradation of TP53 mRNA in mammalian cells [PDF]

, 2015
mRNA deadenylation is under the control of cis-acting regulatory elements, which include AU-rich elements (AREs) and microRNA (miRNA) targeting sites, within the 3′ untranslated region (3′ UTRs) of eukaryotic mRNAs.
Zhang, Xiaokan, Glazman, Galina, Murphy, Michael R., Persaud, Mirjana, Kleiman, Frida E., Devany, Emral   +5 more
core   +1 more source