Results 71 to 80 of about 3,192 (173)

The eIF4E-binding protein Eap1p functions in Vts1p-mediated transcript decay. [PDF]

PLoS ONE, 2012
Sequence-specific RNA binding proteins can induce the degradation of mRNAs through their ability to recruit proteins that trigger transcript destabilization. For example, Vts1p, the S.
Laura M Rendl, Melissa A Bieman, Heli K Vari, Craig A Smibert   +3 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, Volume 600, Issue 6, Page 864-893, March 2026.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Regulation of the Drosophila transcriptome by Pumilio and the CCR4-NOT deadenylase complex

RNA
The sequence-specific RNA-binding protein Pumilio controls Drosophila development; however, the network of mRNAs that it regulates remains incompletely characterized. In this study, we utilize knockdown and knockout approaches coupled with RNA-Seq to measure the impact of Pumilio on the transcriptome of Drosophila cells in culture.
Rebecca J. Haugen, Catherine Barnier, Nathan D. Elrod, Hua Luo, Madeline K. Jensen, Ping Ji, Craig A. Smibert, Howard D. Lipshitz, Eric J. Wagner, P. Lydia Freddolino, Aaron C. Goldstrohm   +10 more
openaire   +2 more sources

Structural basis for inhibition of the deadenylase activity of human CNOT6L [PDF]

FEBS Letters, 2016
Human CNOT6L/CCR4, a member of the endonuclease‐exonuclease‐phosphatase (EEP) family enzymes, is one of the two deadenylase enzymes in the conserved CCR4‐NOT complex. Here, we report inhibitor‐bound crystal structures of the human CNOT6L nuclease domain in complex with the nucleotide CMP and the aminoglycoside neomycin. Deadenylase activity assays show
Qionglin Zhang, Dongke Yan, Erhong Guo, Bojian Ding, Wen Yang, Ruihua Liu, Tadashi Yamamoto, Mark Bartlam   +7 more
openaire   +2 more sources

Genome-Wide Mapping of Decay Factor–mRNA Interactions in Yeast Identifies Nutrient-Responsive Transcripts as Targets of the Deadenylase Ccr4

G3: Genes, Genomes, Genetics, 2018
The Ccr4 (carbon catabolite repression 4)-Not complex is a major regulator of stress responses that controls gene expression at multiple levels, from transcription to mRNA decay.
Jason E. Miller, Liye Zhang, Haoyang Jiang, Yunfei Li, B. Franklin Pugh, Joseph C. Reese   +5 more
doaj   +1 more source

LOTUS domain protein MARF1 binds CCR4-NOT deadenylase complex to post-transcriptionally regulate gene expression in oocytes

Nature Communications, 2018
The RNA-binding protein MARF1 is required for post-transcriptional regulation of mRNAs during mouse oogenesis. Here, by analyzing a Drosophila MARF1 mutant, the authors show that MARF1 recruits CCR4-NOT deadenylase to shorten the poly-A tails of target ...
Li Zhu, Suresh K. Kandasamy, Susan E. Liao, Ryuya Fukunaga   +3 more
doaj   +1 more source

RNA‐Based Therapies for Inherited Metabolic Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Inherited metabolic disorders (IMDs) are a diverse and complex group of genetic conditions resulting from deficiencies in enzymes, transporters, or cofactors. These deficiencies lead to metabolic dysfunction and severe clinical consequences. Despite significant progress in understanding their molecular basis, treatment options remain limited ...
Reddy Sreekanth Vootukuri, Sonam Gurung, Roopkatha Ghosh, Philippa B. Mills, Julien Baruteau, Haiyan Zhou   +5 more
wiley   +1 more source

Application of Deadenylase Electrochemiluminescence Assay for Ricin to Foods in a Plate Format

Journal of Food Protection, 2009
A recently developed bead-based deadenylase electrochemiluminescence assay for ricin is simple and sensitive in its ability to detect ricin, based on the catalytic activity of the toxin subunit, ricin A chain. The assay was modified to work in a 96-well plate format and evaluated by using juice samples.
Chung Y, Cho, William K, Keener, Eric A E, Garber   +2 more
openaire   +2 more sources

The PARN deadenylase targets a discrete set of mRNAs for decay and regulates cell motility in mouse myoblasts.

PLoS Genetics, 2012
PARN is one of several deadenylase enzymes present in mammalian cells, and as such the contribution it makes to the regulation of gene expression is unclear.
Jerome E Lee, Ju Youn Lee, Jarrett Trembly, Jeffrey Wilusz, Bin Tian, Carol J Wilusz   +5 more
doaj   +1 more source

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Xuan Yin, Zengkan Du, Shuya Jiang, Yan Liao, Changli Wang, Jiaqi Li, Haoling Zhang, Ting‐Ting Wei, Wangzheqi Zhang, Zui Zou   +9 more
wiley   +1 more source