Results 51 to 60 of about 3,926 (154)
iScience, 2023 Summary: TRIM24 is an oncogenic chromatin reader that is frequently overexpressed in human tumors and associated with poor prognosis. However, TRIM24 is rarely mutated, duplicated, or rearranged in cancer.
Lalit R. Patel +8 more
doaj +1 more source
Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform
Advanced Science, Volume 13, Issue 37, 3 July 2026.We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng +5 more
wiley +1 more source
Nocturnin, a Deadenylase in Xenopus laevis Retina A Mechanism for Posttranscriptional Control of Circadian-Related mRNA [PDF]
, 2003 Background: Different types of regulation are utilized to produce a robust circadian clock, including regulation at the transcriptional, posttranscriptional, and translational levels.
Green, Carla B, Baggs, Julie E
core +1 more source
Role of Tristetraprolin in the Resolution of Inflammation
Biology, 2021 Inflammation is a crucial part of immune responses towards invading pathogens or tissue damage. While inflammatory reactions are aimed at removing the triggering stimulus, it is important that these processes are terminated in a coordinate manner to ...
Peter Rappl +2 more
doaj +1 more source
Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1353-1363, July 2026.This graphical abstract illustrates the essential role of USB1 in neutrophil maturation. In normal myeloid cells, USB1 acts as an RNA exonuclease, trimming RNA tails to maintain proper RNA network function, which supports the differentiation of myeloid progenitor cells into mature neutrophils.
Hang Li +6 more
wiley +1 more source
Biology Open, 2014 NANOS2 and NANOS3 belong to the Nanos family of proteins that contain a conserved zinc finger domain, which consists of two consecutive CCHC-type zinc finger motifs, and contribute to germ cell development in mice.
Atsushi Suzuki, Yuki Niimi, Yumiko Saga
doaj +1 more source
Noncoding RNAs and the Architecture of Gene Regulation: Focus on Long and Small Regulatory RNAs
WIREs RNA, Volume 17, Issue 4, July/August 2026.NcRNAs play fundamental roles in many facets of cellular homeostasis, systemic physiology and disease outcomes. Historical and current advancements have led to a deeper understanding of ncRNAs' roles, utilizing their diverse and tissue‐specific functions to drive the development of innovative therapeutic tools.
Samuel Z. Desind +2 more
wiley +1 more source
The eIF4E-binding protein Eap1p functions in Vts1p-mediated transcript decay. [PDF]
PLoS ONE, 2012 Sequence-specific RNA binding proteins can induce the degradation of mRNAs through their ability to recruit proteins that trigger transcript destabilization. For example, Vts1p, the S.
Laura M Rendl +3 more
doaj +1 more source
Analysis of the Ccr4-Not deadenylase complex: a biochemical and computational approach [PDF]
, 2017 In eukaryotic cells, the degradation of the mRNA poly(A) tail (deadenylation) is a crucial step in the regulation of gene expression. The Ccr4-Not complex is the major deadenylase enzyme involved in the mRNA deadenylation.
Balacco, Dario Leonardo
core
Molecular analysis of the Ccr4-Not deadenylase: relevance to human disease [PDF]
In eukaryotes, the removal of the poly (A) tail of cytoplasmic mRNA (deadenylation) is a crucial step in post-transcriptional gene regulation. A major enzyme involved in regulated mRNA deadenylation is the Ccr4-Not deadenylase, which contains two ...
Airhihen, Blessing
core +3 more sources