Results 51 to 60 of about 6,008 (204)
The influence of microRNAs and poly(A) tail length on endogenous mRNA–protein complexes [PDF]
, 2017 Background: All mRNAs are bound in vivo by proteins to form mRNA-protein complexes (mRNPs), but changes in the composition of mRNPs during posttranscriptional regulation remain largely unexplored.
Bartel, David +9 more
core +1 more source
CUG-BP binds to RNA substrates and recruits PARN deadenylase [PDF]
RNA, 2006 CUG-BP is the human homolog of the Xenopus EDEN-BP, which was shown previously to bind to mRNAs, such as c-mos, that exhibit rapid deadenylation following fertilization of the oocyte. While several studies have focused on roles of CUG-BP as a splicing or translation regulator in mammalian cells, its role in mRNA decay has not been examined in detail ...
Karen C M, Moraes +2 more
openaire +2 more sources
Cells, 2019 Poly(A)-specific ribonuclease (PARN), a multifunctional multi-domain deadenylase, is crucial to the regulation of mRNA turnover and the maturation of various non-coding RNAs.
Tian-Li Duan +3 more
doaj +1 more source
An Unconventional Human Ccr4-Caf1 Deadenylase Complex in Nuclear Cajal Bodies [PDF]
Molecular and Cellular Biology, 2007 mRNA deadenylation is a key process in the regulation of translation and mRNA turnover. In Saccharomyces cerevisiae, deadenylation is primarily carried out by the Ccr4p and Caf1p/Pop2p subunits of the Ccr4-Not complex, which is conserved in eukaryotes including humans.
Eileen, Wagner +2 more
openaire +2 more sources
An mRNA decapping mutant deficient in P body assembly limits mRNA stabilization in response to osmotic stress [PDF]
, 2017 Yeast is exposed to changing environmental conditions and must adapt its genetic program to provide a homeostatic intracellular environment. An important stress for yeast in the wild is high osmolarity.
A Totaro +58 more
core +1 more source
Role of Circadian Deadenylase Nocturnin in the Mitochondria
The FASEB Journal, 2018 The circadian rhythm is an evolutionarily conserved process that drives rhythmic behavior and physiology with a period of approximately 24 hours. Circadian rhythms are generated by the heterodimeric transcription factors CLOCK/BMAL1. CLOCK/BMAL1 binds to E‐boxes across the genome and drives the transcription of many genes, including their own ...
Anne Ojo, Isara Laothamatas, Carla Green
openaire +1 more source
PLoS ONE, 2012 The human BTG/TOB protein family comprises six members (BTG1, BTG2/PC3/Tis21, BTG3/Ana, BTG4/PC3B, TOB1/Tob, and TOB2) that are characterised by a conserved BTG domain.
Rachel Doidge +3 more
doaj +1 more source
Breaking the A chain: regulating mRNAs in development through CCR4 deadenylase [PDF]
F1000 Biology Reports, 2009 Post-transcriptional mechanisms of gene regulation have long been implicated in specifying embryonic pattern in many organisms. Experiments in Caenorhabditis elegans, Drosophila, and Xenopus have recently converged, pointing to the CCR4 deadenylase complex as a key effector that modulates the expression of proteins from specific germline mRNAs.
Moore, Jocelyn, Lasko, Paul
openaire +2 more sources
A novel class of microRNA-recognition elements that function only within open reading frames. [PDF]
, 2018 MicroRNAs (miRNAs) are well known to target 3' untranslated regions (3' UTRs) in mRNAs, thereby silencing gene expression at the post-transcriptional level.
A Aizer +85 more
core +2 more sources
Cell Reports, 2015 Eukaryotic mRNA degradation often initiates with the recruitment of the CCR4-NOT deadenylase complex and decay factors to the mRNA 3′ terminus. How the 3′-proximal decay machinery interacts with the 5′-terminal cap structure in order to engender mRNA ...
Tamiko Nishimura +6 more
doaj +1 more source