Results 31 to 40 of about 3,192 (173)
Global view on the metabolism of RNA poly(A) tails in yeast Saccharomyces cerevisiae
Nature Communications, 2021 RNA polyadenosine tails are important for the export, translation and stability of mRNAs and play a role in non-coding RNA biogenesis. Here the authors measure yeast poly(A) tail lengths by direct RNA sequencing, revealing its dynamics in yeast ...
Agnieszka Tudek +7 more
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Opposing Polymerase-Deadenylase Activities Regulate Cytoplasmic Polyadenylation [PDF]
Molecular Cell, 2006 Cytoplasmic polyadenylation is one mechanism that regulates translation in early animal development. In Xenopus oocytes, polyadenylation of dormant mRNAs, including cyclin B1, is controlled by the cis-acting cytoplasmic polyadenylation element (CPE) and hexanucleotide AAUAAA through associations with CPEB and CPSF, respectively.
Kim, Jong Heon, Richter, Joel D.
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HELZ directly interacts with CCR4–NOT and causes decay of bound mRNAs
Life Science Alliance, 2019 The putative UPF1-like SF1 helicase HELZ directly interacts with the CCR4–NOT deadenylase complex to induce translational repression and 5′-to-3′ decay of bound mRNAs. Eukaryotic superfamily (SF) 1 helicases have been implicated in various aspects of RNA
Aoife Hanet +10 more
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Role of Cnot6l in maternal mRNA turnover
Life Science Alliance, 2018 Mice lacking Cnot6l , a deadenylase component of the CCR4–NOT complex, are viable, but females have ∼40% smaller litters. Cnot6l is a maternal-effect gene acting in maternal mRNA degradation.
Filip Horvat +9 more
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FEBS Open Bio, 2019 In eukaryotic cells, cytoplasmic mRNA is characterised by a 3′ poly(A) tail. The shortening and removal of poly(A) tails (deadenylation) by the Ccr4‐Not nuclease complex leads to reduced translational efficiency and RNA degradation.
Blessing Airhihen +4 more
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Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex [PDF]
Nucleic Acids Research, 2021 Abstract The CCR4 and CAF1 deadenylases physically interact to form the CCR4-CAF1 complex and function as the catalytic core of the larger CCR4-NOT complex. Together, they are responsible for the eventual removal of the 3′-poly(A) tail from essentially all cellular mRNAs and consequently play a central role in the posttranscriptional ...
Ying Chen +3 more
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Cells, 2019 Poly(A)-specific ribonuclease (PARN), a multifunctional multi-domain deadenylase, is crucial to the regulation of mRNA turnover and the maturation of various non-coding RNAs.
Tian-Li Duan +3 more
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Integrated Deadenylase Genetic Association Network and Transcriptome Analysis in Thoracic Carcinomas
Molecules, 2022 The poly(A) tail at the 3′ end of mRNAs determines their stability, translational efficiency, and fate. The shortening of the poly(A) tail, and its efficient removal, triggers the degradation of mRNAs, thus, regulating gene expression.
Athanasios Kyritsis +11 more
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Role of Circadian Deadenylase Nocturnin in the Mitochondria
The FASEB Journal, 2018 The circadian rhythm is an evolutionarily conserved process that drives rhythmic behavior and physiology with a period of approximately 24 hours. Circadian rhythms are generated by the heterodimeric transcription factors CLOCK/BMAL1. CLOCK/BMAL1 binds to E‐boxes across the genome and drives the transcription of many genes, including their own ...
Anne Ojo, Isara Laothamatas, Carla Green
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PLoS ONE, 2012 The human BTG/TOB protein family comprises six members (BTG1, BTG2/PC3/Tis21, BTG3/Ana, BTG4/PC3B, TOB1/Tob, and TOB2) that are characterised by a conserved BTG domain.
Rachel Doidge +3 more
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