Results 11 to 20 of about 3,192 (173)

Biochemical and biophysical characterization of the deadenylase CrCaf1 from Chlamydomonas reinhardtii. [PDF]

PLoS ONE, 2013
The modulation of mRNA turnover has been increasingly recognized as a hotpoint for gene expression regulation at the post-transcriptional level. In eukaryotic cells, most mRNAs are degraded via the deadenylation-dependent pathway, in which the removal of
Jia-Quan Zhang, Guang-Jun He, Yong-Bin Yan   +2 more
doaj   +4 more sources

Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications. [PDF]

Wiley Interdiscip Rev RNA
Schematic representation of the molecular interplay between PARN, telomerase‐associated, and the involvement of p53 in regulating telomere maintenance and genome stability. The top panel shows how normal PARN levels are involved in regulating p53 levels and balanced telomerase activity through their regulatory interaction with TERC and TERRA, thus ...
Felicitus S, Pinto SS, Madagundapalli Ramakrishna SS, Nanjappa DP, Chakraborty G, Chakraborty A.   +5 more
europepmc   +2 more sources

Translational Repression by Deadenylases [PDF]

Journal of Biological Chemistry, 2010
The CCR4-CAF1-NOT complex is a major cytoplasmic deadenylation complex in yeast and mammals. This complex associates with RNA-binding proteins and microRNAs to repress translation of target mRNAs. We sought to determine how CCR4 and CAF1 participate in repression and control of maternal mRNAs using Xenopus laevis oocytes.
Cooke, Amy, Priggie, Andrew, Wickens, Marvin   +2 more
openaire   +2 more sources

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity. [PDF]

FEBS Open Bio
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Soeda S, Montrose M, Takahashi A, Ishida R, Burriel S, Ohmine N, Natsume T, Adachi S, Kim M, Yamamoto T.   +9 more
europepmc   +2 more sources

Pan2-Pan3 Complex-Mediated Deadenylation Enforces mRNA Quality Control for Infection of the Rice Blast Fungus. [PDF]

Adv Sci (Weinh)
Discovery that deadenylation, rather than transcription, acts as the rate‐limiting step for developmental timing in a plant pathogen. Evidence that P‐body integrity and mRNA decay are mechanistically coupled to rapid cellular differentiation under environmental stress. Identification of Pan2‐Pan3 as a pathogen‐specific “meta‐virulence factor” absent in
Lv Z, Feng J, Zhou S, Qu Z, Peng J, Chen XL, Chen D.   +6 more
europepmc   +2 more sources

Expanding the repertoire of deadenylases [PDF]

RNA Biology, 2017
Deadenylases belong to an expanding family of exoribonucleases involved mainly in mRNA stability and turnover, with the exception of PARN which has additional roles in the biogenesis of several important non-coding RNAs, including miRNAs and piRNAs. Recently, PARN in C. elegans and its homolog PNLDC1 in B.
Ilias, Skeparnias, Dimitrios, Αnastasakis, Athanasios-Nasir, Shaukat, Katerina, Grafanaki, Constantinos, Stathopoulos   +4 more
openaire   +2 more sources

A Comprehensive Phylogenetic Analysis of Deadenylases [PDF]

Evolutionary Bioinformatics, 2013
Deadenylases catalyze the shortening of the poly(A) tail at the messenger ribonucleic acid (mRNA) 3′-end in eukaryotes. Therefore, these enzymes influence mRNA decay, and constitute a major emerging group of promising anti-cancer pharmacological targets.
Vlachakis, Dimitrios, Pavlopoulou, ATHANASIA, Kossida, Sophia, Balatsos, Nikolaos A. A.   +3 more
openaire   +5 more sources

BTG/TOB factors impact deadenylases [PDF]

Trends in Biochemical Sciences, 2009
BTG/TOB factors are a family of antiproliferative proteins whose expression is altered in numerous cancers. They have been implicated in cell differentiation, development and apoptosis. Although proposed to affect transcriptional regulation, these factors interact with CAF1, a subunit of the main eukaryotic deadenylase, and with poly(A)-binding ...
Mauxion, Fabienne, Chen, Chyi-Ying A, Séraphin, Bertrand, Shyu, Ann-Bin   +3 more
openaire   +2 more sources

USB1 is a miRNA deadenylase that regulates hematopoietic development

Science, 2023
Mutations in the 3′ to 5′ RNA exonuclease USB1 cause hematopoietic failure in poikiloderma with neutropenia (PN). Although USB1 is known to regulate U6 small nuclear RNA maturation, the molecular mechanism underlying PN remains undetermined, as pre-mRNA splicing is unaffected in patients.
Ho-Chang Jeong, Siddharth Shukla, Wilson Chun Fok, Thao Ngoc Huynh, Luis Francisco Zirnberger Batista, Roy Parker   +5 more
openaire   +2 more sources

The CCR4–NOT Deadenylase Complex Maintains Adipocyte Identity [PDF]

International Journal of Molecular Sciences, 2019
Shortening of poly(A) tails triggers mRNA degradation; hence, mRNA deadenylation regulates many biological events. In the present study, we generated mice lacking the Cnot1 gene, which encodes an essential scaffold subunit of the CCR4–NOT deadenylase complex in adipose tissues (Cnot1-AKO mice) and we examined the role of CCR4–NOT in adipocyte function.
Akinori Takahashi, Shohei Takaoka, Shungo Kobori, Tomokazu Yamaguchi, Sara Ferwati, Keiji Kuba, Tadashi Yamamoto, Toru Suzuki   +7 more
openaire   +2 more sources