Results 21 to 30 of about 3,926 (154)
Pan2-Pan3 Complex-Mediated Deadenylation Enforces mRNA Quality Control for Infection of the Rice Blast Fungus. [PDF]
Adv Sci (Weinh)Discovery that deadenylation, rather than transcription, acts as the rate‐limiting step for developmental timing in a plant pathogen. Evidence that P‐body integrity and mRNA decay are mechanistically coupled to rapid cellular differentiation under environmental stress. Identification of Pan2‐Pan3 as a pathogen‐specific “meta‐virulence factor” absent in
Lv Z +6 more
europepmc +2 more sources
The yeast PUF protein Puf5 has Pop2-independent roles in response to DNA replication stress. [PDF]
PLoS ONE, 2010 PUFs are RNA binding proteins that promote mRNA deadenylation and decay and inhibit translation. Yeast Puf5 is the prototype for studying PUF-dependent gene repression.
Ana Traven +3 more
doaj +1 more source
A fluorescence-based assay suitable for quantitative analysis of deadenylase enzyme activity [PDF]
, 2013 In eukaryotic cells, the shortening and removal of the poly(A) tail of cytoplasmic mRNA by deadenylase enzymes is a critical step in posttranscriptional gene regulation.
Fischer, Peter M. +7 more
core +1 more source
Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways
Viruses, 2016 To successfully replicate, viruses protect their genomic material from degradation by the host cell. RNA viruses must contend with numerous destabilizing host cell processes including mRNA decay pathways and viral RNA (vRNA) degradation resulting from ...
Wendy Ullmer, Bert L. Semler
doaj +1 more source
Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex
Frontiers in Genetics, 2013 The shortening of the poly(A) tail of cytoplasmic mRNA (deadenylation) is a pivotal step in the regulation of gene expression in eukaryotic cells. Deadenylation impacts on both regulated mRNA decay as well as the rate of mRNA translation.
Gerlof Sebastiaan Winkler +1 more
doaj +1 more source
Journal of Inflammation, 2021 Background Tristetraprolin (TTP) family proteins contain conserved tandem CCCH zinc-finger binding to AU-rich elements and C-terminal NOT1-binding domain.
Hsin-Hui Hsieh +8 more
doaj +1 more source
Global view on the metabolism of RNA poly(A) tails in yeast Saccharomyces cerevisiae
Nature Communications, 2021 RNA polyadenosine tails are important for the export, translation and stability of mRNAs and play a role in non-coding RNA biogenesis. Here the authors measure yeast poly(A) tail lengths by direct RNA sequencing, revealing its dynamics in yeast ...
Agnieszka Tudek +7 more
doaj +1 more source
HELZ directly interacts with CCR4–NOT and causes decay of bound mRNAs
Life Science Alliance, 2019 The putative UPF1-like SF1 helicase HELZ directly interacts with the CCR4–NOT deadenylase complex to induce translational repression and 5′-to-3′ decay of bound mRNAs. Eukaryotic superfamily (SF) 1 helicases have been implicated in various aspects of RNA
Aoife Hanet +10 more
doaj +1 more source
Role of Cnot6l in maternal mRNA turnover
Life Science Alliance, 2018 Mice lacking Cnot6l , a deadenylase component of the CCR4–NOT complex, are viable, but females have ∼40% smaller litters. Cnot6l is a maternal-effect gene acting in maternal mRNA degradation.
Filip Horvat +9 more
doaj +1 more source
FEBS Open Bio, 2019 In eukaryotic cells, cytoplasmic mRNA is characterised by a 3′ poly(A) tail. The shortening and removal of poly(A) tails (deadenylation) by the Ccr4‐Not nuclease complex leads to reduced translational efficiency and RNA degradation.
Blessing Airhihen +4 more
doaj +1 more source