Results 21 to 30 of about 3,192 (173)
eLife, 2020 Stem cells support tissue maintenance, but the mechanisms that coordinate the rate of stem cell self-renewal with differentiation at a population level remain uncharacterized. We find that two PUF family RNA-binding proteins FBF-1 and FBF-2 have opposite
Xiaobo Wang +6 more
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FEBS Open Bio, 2022 The 24‐h molecular clock is based on the stability of rhythmically expressed transcripts. The shortening of the poly(A) tail of mRNAs is often the first and rate‐limiting step that determines the lifespan of a mRNA and is catalyzed by deadenylases ...
Rafailia A. A. Beta +7 more
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Human Ccr4–Not complexes contain variable deadenylase subunits [PDF]
Biochemical Journal, 2009 The Ccr4–Not complex is evolutionarily conserved and important for regulation of mRNA synthesis and decay. The composition of the yeast complex has been well described. Orthologues of the yeast Ccr4–Not components have been identified in human cells including multiple subunits with mRNA deadenylase activity.
Lau, N.C. +6 more
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The yeast PUF protein Puf5 has Pop2-independent roles in response to DNA replication stress. [PDF]
PLoS ONE, 2010 PUFs are RNA binding proteins that promote mRNA deadenylation and decay and inhibit translation. Yeast Puf5 is the prototype for studying PUF-dependent gene repression.
Ana Traven +3 more
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Regulation of the Drosophila transcriptome by Pumilio and CCR4-NOT deadenylase
, 2023 ABSTRACT The sequence-specific RNA-binding protein Pumilio controls development of Drosophila ; however, the network of mRNAs that it regulates remains incompletely characterized. In this study, we utilize knockdown and knockout approaches coupled with RNA-Seq to measure the impact ...
Rebecca J. Haugen +10 more
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Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways
Viruses, 2016 To successfully replicate, viruses protect their genomic material from degradation by the host cell. RNA viruses must contend with numerous destabilizing host cell processes including mRNA decay pathways and viral RNA (vRNA) degradation resulting from ...
Wendy Ullmer, Bert L. Semler
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Conservation of the deadenylase activity of proteins of the Caf1 family in human [PDF]
RNA, 2005 The yeast Pop2 protein, belonging to the eukaryotic Caf1 family, is required for mRNA deadenylation in vivo. It also catalyzes poly(A) degradation in vitro, even though this property has been questioned. Caf1 proteins are related to RNase D, a feature supported by the recently published structure of Pop2.
Claire, Bianchin +4 more
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USB1 Is a miRNA Deadenylase That Regulates Hematopoietic Development
Blood, 2021 Abstract Poikiloderma with neutropenia (PN)is an autosomal-recessive bone marrow failure (BMF) syndrome in which patients harbor homozygous or compound heterozygous mutations in the human gene C16orf57, which encodes the evolutionarily conserved RNA 3' to 5' exonuclease U6 biogenesis 1 (USB1).
Ho-Chang Jeong +3 more
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Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex
Frontiers in Genetics, 2013 The shortening of the poly(A) tail of cytoplasmic mRNA (deadenylation) is a pivotal step in the regulation of gene expression in eukaryotic cells. Deadenylation impacts on both regulated mRNA decay as well as the rate of mRNA translation.
Gerlof Sebastiaan Winkler +1 more
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Journal of Inflammation, 2021 Background Tristetraprolin (TTP) family proteins contain conserved tandem CCCH zinc-finger binding to AU-rich elements and C-terminal NOT1-binding domain.
Hsin-Hui Hsieh +8 more
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