Results 101 to 110 of about 6,008 (204)

Anti‐proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase [PDF]

The EMBO Journal, 2011
Tob is a member of the anti-proliferative protein family, which functions in transcription and mRNA decay. We have previously demonstrated that Tob is involved in the general mechanism of mRNA decay by mediating mRNA deadenylation through interaction with Caf1 and a general RNA-binding protein, PABPC1.
Nao, Hosoda, Yuji, Funakoshi, Masato, Hirasawa, Ryota, Yamagishi, Yukako, Asano, Ryu, Miyagawa, Koichi, Ogami, Masafumi, Tsujimoto, Shin-ichi, Hoshino   +8 more
openaire   +2 more sources

CNOT1 regulates circadian behaviour through Per2 mRNA decay in a deadenylation-dependent manner

RNA Biology, 2022
Circadian clocks are an endogenous internal timekeeping mechanism that drives the rhythmic expression of genes, controlling the 24 h oscillatory pattern in behaviour and physiology.
Haytham Mohamed Aly Mohamed, Akinori Takahashi, Saori Nishijima, Shungo Adachi, Iori Murai, Hitoshi Okamura, Tadashi Yamamoto   +6 more
doaj   +1 more source

Emergence of macroscopic simplicity from the Tumor Necrosis Factor-alpha signaling dynamics [PDF]

, 2011
The Tumor Necrosis Factor-α (TNF-α), a cytokine produced during the innate immune response to invading pathogens, is involved in numerous fundamental cellular processes.
Kentaro Hayashi, Kumar Selvarajoo, Masa Tsuchiya, Masaru Tomita, Vincent Piras   +4 more
core   +1 more source

Regulation of the Drosophila transcriptome by Pumilio and CCR4-NOT deadenylase

, 2023
ABSTRACTThe sequence-specific RNA-binding protein Pumilio controls development ofDrosophila; however, the network of mRNAs that it regulates remains incompletely characterized. In this study, we utilize knockdown and knockout approaches coupled with RNA-Seq to measure the impact of Pumilio on the transcriptome ofDrosophilacells.
Rebecca J. Haugen, Catherine Barnier, Nathan D. Elrod, Hua Luo, Madeline K. Jensen, Ping Ji, Craig A. Smibert, Howard D. Lipshitz, Eric J. Wagner, P. Lydia Freddolino, Aaron C. Goldstrohm   +10 more
openaire   +2 more sources

m6A RNA Modification Controls HTLV‐1 Tax and Host Gene Expression

Genes to Cells, Volume 30, Issue 6, November 2025.
Our study shows that m6A regulation is critical for controlling HTLV‐1, shaping both viral transcripts and host gene programs, thereby illuminating latency mechanisms and suggesting tractable targets for therapy and prevention. ABSTRACT Human T‐cell Leukemia Virus Type 1 (HTLV‐1) is a pathogenic human retrovirus that is responsible for intractable ...
Rei Gibu, Kodai Gibu, Kako Suzuki, Yuetsu Tanaka, Kaoru Uchimaru, Makoto Yamagishi   +5 more
wiley   +1 more source

Translation efficiency is a determinant of the magnitude of miRNA-mediated repression [PDF]

, 2017
MicroRNAs are well known regulators of mRNA stability and translation. However, the magnitude of both translational repression and mRNA decay induced by miRNA binding varies greatly between miRNA targets.
Cottrell, Kyle A, Djuranovic, Sergej, Szczesny, Pawel   +2 more
core   +3 more sources

NamiRNA‐Enhancer Network: The Changing Era Challenge and Chance of miRNA

Advanced Science, Volume 12, Issue 39, October 20, 2025.
MiRNAs (miRNAs) regulate diverse biological processes across species. Unlike canonical miRNA‐mediated gene repression, Nuclear Activating miRNAs (NamiRNAs) can efficiently upregulate gene expression by targeting enhancers. This review systematically summarizes recent advances in NamiRNA research, elucidates the theory of NamiRNA‐Enhancer‐mediated Gene ...
Lu Chen, Ying Liang, Hongyan Wei, Mengxing Liu, Jin Wu, Wei Li, Wenxuan Li, Yuxiao Jin, Yinshan Li, Wei Zhao, Min Xiao, Kaicheng Zhou, Shuai Yang, Wenqiang Yu   +13 more
wiley   +1 more source

Eukaryotic translation initiation factor 4All contributes to microRNA-122 regulation of hepatitis C virus replication [PDF]

, 2018
Hepatitis C virus (HCV) is a positive sense RNA virus that persistently infects human liver, leading to cirrhosis and hepatocellular carcinoma. HCV replication requires the liver-specific microRNA-122 (miR-122).
Aimee L Parsons, Biegel, Bradrick, Braun, Catherine L Jopling, Chekulaeva, Chen, Choudhary Shoaib Ahmed, Duffy, Fabian, Galicia-Vazquez, Galicia-Vazquez, Henke, Huys, Ikeda, Iwakawa, Iwasaki, Jangra, Jangra, Jopling, Jopling, Kuzuoglu-Ozturk, Kyono, Li, Li, Li, Li, Lindenbach, Luna, Masaki, Mathys, Meijer, Norman, Pawlotsky, Pestova, Poppy L Winlow, Radle, Roberts, Roberts, Ruggieri, Scheel, Scheel, Scheller, Schweingruber, Sedano, Spriggs, Thibault, Thrift, Yi   +48 more
core   +2 more sources

Interaction of antiproliferative protein Tob with the CCR4‐NOT deadenylase complex

Cancer Science, 2008
Tob protein, when overexpressed, suppresses growth of NIH3T3 cells, presumably by regulating expression of various growth‐related genes. However, the molecular mechanisms underlying Tob‐mediated regulation of gene expression have been obscure. To address this issue we established stable Tob‐expressing cell lines and used a proteomics approach to ...
Takashi, Miyasaka, Masahiro, Morita, Kentaro, Ito, Toru, Suzuki, Hiroyuki, Fukuda, Shizu, Takeda, Jun-Ichiro, Inoue, Kentaro, Semba, Tadashi, Yamamoto   +8 more
openaire   +2 more sources

RNF187 Facilitates Proliferation and Migration of Human Spermatogonial Stem Cells Through WDR77 Polyubiquitination

Cell Proliferation, Volume 58, Issue 10, October 2025.
RNF187 mediates the polyubiquitination and subsequent degradation of WDR77, reduces H4R3me2s catalysed by the WDR77/PRMT5 complex, and derepresses the transcription of EGR1, thereby promoting the proliferation and migration of human SSCs. ABSTRACT The E3 ubiquitin ligase RNF187, also known as RING domain AP1 coactivator‐1, is a member of the RING ...
Haoyue Hu, Xiaoxue Xi, Bing Jiang, Kehan Wang, Tiantian Wu, Xia Chen, Yueshuai Guo, Tao Zhou, Xiaoyan Huang, Jun Yu, Tingting Gao, Yibo Wu, Bo Zheng   +12 more
wiley   +1 more source