Results 51 to 60 of about 9,376 (189)
Targeted mRNA Degradation by Deadenylation-Independent Decapping [PDF]
Molecular Cell, 2004 Modulating the rate of mRNA degradation is a fast and efficient way to control gene expression. In a yeast strain deleted of EDC3, a component of the decapping machinery conserved in eukaryotes, the transcript coding the ribosomal protein Rps28b is specifically stabilized, as demonstrated by microarray and time course experiments.
Badis, Gwenaël +3 more
openaire +3 more sources
Deadenylation speed and mRNA stability : revisiting an old dogma
, 2022 Recherche décrite dans la prépublication : https://hal.science/hal-04051068International audienceGene expression and its regulation depend on mRNA degradation. In eukaryotes, degradation is controlled by deadenylation rates, since a short poly(A) tail is
Badis, Gwenaël
core +3 more sources
The BTG2 protein is a general activator of mRNA deadenylation [PDF]
The EMBO Journal, 2008 BTG2 is a prototype member of the BTG/Tob family of antiproliferative proteins, originally identified as a primary response gene induced by growth factors and tumour promoters. Its expression has been linked to diverse cellular processes such as cell-cycle progression, differentiation or apoptosis.
Fabienne, Mauxion +2 more
openaire +2 more sources
Genes & Development, 1999 We have developed an in vitro mRNA stability system using HeLa cell cytoplasmic S100 extracts and exogenous polyadenylated RNA substrates that reproduces regulated aspects of mRNA decay. The addition of cold poly(A) competitor RNA activated both a sequence-specific deadenylase activity in the extracts as well as a potent, ATP-dependent ribonucleolytic ...
L P, Ford +3 more
openaire +2 more sources
PUF Protein-mediated Deadenylation Is Catalyzed by Ccr4p [PDF]
Journal of Biological Chemistry, 2007 PUF proteins control gene expression by binding to the 3'-untranslated regions of specific mRNAs and triggering mRNA decay or translational repression. Here we focus on the mechanism of PUF-mediated regulation. The yeast PUF protein, Mpt5p, regulates HO mRNA and stimulates removal of its poly(A) tail (i.e. deadenylation).
Aaron C, Goldstrohm +3 more
openaire +2 more sources
Advanced Science, EarlyView.This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh +2 more
wiley +1 more source
The function of PAB1 in translation and in PUF3 dependent deadenylation [PDF]
, 2007 The involvement of the poly(A)-binding protein (PAB1) in deadenylation and translation is well known. How PAB1 inhibits deadenylation and promotes translation is not well understood.
Lee, Darren J
core +1 more source
FEBS Open Bio, 2022 The 24‐h molecular clock is based on the stability of rhythmically expressed transcripts. The shortening of the poly(A) tail of mRNAs is often the first and rate‐limiting step that determines the lifespan of a mRNA and is catalyzed by deadenylases ...
Rafailia A. A. Beta +7 more
doaj +1 more source
Advanced Science, EarlyView.Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Peng Jiang +11 more
wiley +1 more source
The control of mRNA deadenylation by MAPKAP kinase 2 and tristetraprolin [PDF]
, 2011 The abundance of a given mRNA is a function of its rates of synthesis and degradation. The regulation of mRNA stability is therefore an important means of modulating gene expression.
Marchese, Francesco Paolo
core +1 more source