Results 1 to 10 of about 29,926 (230)
Role of Decorin in the Lens and Ocular Diseases [PDF]
Cells, 2022 Decorin is an archetypal member of the small leucine-rich proteoglycan gene family and is involved in various biological functions and many signaling networks, interacting with extra-cellular matrix (ECM) components, growth factors, and receptor tyrosine
Eri Kubo +4 more
doaj +3 more sources
Decorin Protects Cardiac Myocytes against Simulated Ischemia/Reperfusion Injury [PDF]
Molecules, 2020 Search for new cardioprotective therapies is of great importance since no cardioprotective drugs are available on the market. In line with this need, several natural biomolecules have been extensively tested for their potential cardioprotective effects ...
Renáta Gáspár +12 more
doaj +3 more sources
The dermatan sulfate proteoglycan decorin modulates α2β1 integrin and the vimentin intermediate filament system during collagen synthesis. [PDF]
PLoS ONE, 2012 Decorin, a small leucine-rich proteoglycan harboring a dermatan sulfate chain at its N-terminus, is involved in regulating matrix organization and cell signaling. Loss of the dermatan sulfate of decorin leads to an Ehlers-Danlos syndrome characterized by
Oliver Jungmann +8 more
doaj +22 more sources
npj Regenerative Medicine, 2023 Heart failure (HF) remains a global public health burden and often results following myocardial infarction (MI). Following injury, cardiac fibrosis forms in the myocardium which greatly hinders cellular function, survival, and recruitment, thus severely ...
Priya Mohindra +11 more
doaj +2 more sources
Journal of Experimental & Clinical Cancer Research, 2023 Background The interplay between gut microbiota and tumor microenvironment (TME) in the pathogenesis of colorectal cancer (CRC) is largely unknown. Here, we elucidated the functional role of B.
Yifeng Lin +7 more
doaj +2 more sources
Uterine dysfunction in biglycan and decorin deficient mice leads to dystocia during parturition. [PDF]
PLoS ONE, 2012 Cesarean birth rates are rising. Uterine dysfunction, the exact mechanism of which is unknown, is a common indication for Cesarean delivery. Biglycan and decorin are two small leucine-rich proteoglycans expressed in the extracellular matrix of ...
Zhiping Wu +5 more
doaj +3 more sources
The Role of Decorin in Autoimmune and Inflammatory Diseases
Journal of Immunology Research, 2022 Decorin is an extracellular matrix protein that belongs to the family of small leucine-rich proteoglycans. As a matrix protein, the first discovered role of decorin is participating in collagen fibril formation. Many other functions of decorin in various
Yuanji Dong, Jixin Zhong, Lingli Dong
doaj +2 more sources
Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosis
Acta Neuropathologica Communications, 2022 Cerebrospinal fluid (CSF) biomarkers play an important role in diagnosing Alzheimer’s disease (AD) which is characterized by amyloid-β (Aβ) amyloidosis. Here, we used two App knock-in mouse models, App NL-F/NL-F and App NL-G-F/NL-G-F , exhibiting AD-like
Richeng Jiang +24 more
doaj +2 more sources
Frontiers in Oncology, 2021 Decorin exhibits inhibitory effects in tumorigenesis in various types of cancers. The clinical characteristics of 42 patients with GBM were reviewed and analyzed.
Yanfei Jia +6 more
doaj +2 more sources
Possible dual role of decorin in abdominal aortic aneurysm. [PDF]
PLoS ONE, 2015 Abdominal aortic aneurysm (AAA) is characterized by chronic inflammation, which leads to pathological remodeling of the extracellular matrix. Decorin, a small leucine-rich repeat proteoglycan, has been suggested to regulate inflammation and stabilize the
Koshiro Ueda +5 more
doaj +3 more sources