Results 111 to 120 of about 29,996 (293)
A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, EarlyView.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape
The FEBS Journal, EarlyView.The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto +9 more
wiley +1 more source
Decorin‐binding adhesins from Borrelia burgdorferi [PDF]
Molecular Microbiology, 1998 Lyme disease is a tick‐transmitted infection caused by the spirochete Borrelia burgdorferi. Ticks deposit B. burgdorferi into the dermis of the host, where they eventually become associated with collagen fibres. We demonstrated previously that B. burgdorferi is unable to bind collagen, but can bind the collagen‐associated proteoglycan decorin and ...
B P, Guo +4 more
openaire +2 more sources
Effect of human myoblasts on tenogenic progression in 2D and 3D culture models
Journal of Anatomy, EarlyView.We investigated whether factors released from muscle derived myogenic cells enhance tenogenic progressions of human tendon derived cells using two‐dimensional (2D) culture model and a three‐dimensional (3D)‐engineered tendon construct culture model.
Yoshifumi Tsuchiya +3 more
wiley +1 more source
Decorin promotes robust axon growth on inhibitory CSPGs and myelin via a direct effect on neurons
Neurobiology of Disease, 2008 Inhibitory chondroitin sulfate proteoglycans (CSPGs) and myelin-associated molecules are major impediments to axon regeneration within the adult central nervous system (CNS).
Kenneth Minor +5 more
doaj +1 more source
European Journal of Histochemistry, 2020 The gene expression and protein synthesis of small leucine-rich proteoglycans (SLRPs), including decorin, biglycan, fibromodulin, and lumican, was analyzed in the context of the hypothesis that they are closely related to tooth formation.
Angammana Randilini +2 more
doaj +1 more source
Chronic tendon pathology: molecular basis and therapeutic implications [PDF]
, 2005 Tendons are frequently affected by chronic pain or rupture. Many causative factors have been implicated in the pathology, which until relatively recently was under-researched and poorly understood.
Riley, GP
core +1 more source
WISP-1 Binds to Decorin and Biglycan [PDF]
Journal of Biological Chemistry, 2001 Wnt-1-induced secreted protein 1 (WISP-1) is a member of the CCN (connective tissue growth factor, Cyr61, NOV) family of growth factors. Structural and experimental evidence suggests that CCN family member activities are modulated by their interaction with sulfated glycoconjugates.
L, Desnoyers, D, Arnott, D, Pennica
openaire +2 more sources
Annals of the New York Academy of Sciences, EarlyView.Myocardial sleeves of the pulmonary veins in racehorses with paroxysmal atrial fibrillation exhibit upregulated pathways associated with tissue structure remodeling. Pathways related to the extracellular matrix and cellular components differ significantly from those in healthy horses.
Magdalena Arevalo‐Turrubiarte +8 more
wiley +1 more source
Higher Decorin Levels in Bone Marrow Plasma Are Associated with Superior Treatment Response to Novel Agent-Based Induction in Patients with Newly Diagnosed Myeloma - A Retrospective Study. [PDF]
PLoS ONE, 2015 The growth of myeloma cells depends on bone marrow (BM) stroma consisting of stromal cells, secreted cytokines and the extracellular matrix (ECM). Decorin, a small leucine-rich proteoglycan in the ECM, is a signaling ligand and native anti-tumor agent ...
Shang-Yi Huang +12 more
doaj +1 more source