Results 151 to 160 of about 11,453 (186)

Decorin suppresses tumor cell-mediated angiogenesis [PDF]

Oncogene, 2002
The progressive growth of most neoplasms is dependent upon the establishment of new blood vessels, a process regulated by tumor-secreted factors and matrix proteins. We examined the in vitro and in vivo angiogenic ability of conditioned media obtained from fibrosarcoma, carcinoma, and osteosarcoma cells and their decorin-transfected counterparts. Human
Cigdem Yenisey, Renato V Iozzo
exaly   +3 more sources

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Effect of Exogenous Decorin on Cell Morphology and Attachment of Decorin-Deficient Fibroblasts

Journal of Biochemistry, 1996
We have reported deficient expression of decorin on skin fibroblasts from a patient with carbohydrate-deficient glycoprotein syndrome type I [Gu, J. and Wada, Y. (1995) J. Biochem. 117, 1276-1279]. The characteristics of fibroblasts from this patient included increased cell spreading and reduced proliferation.
J, Gu, Y, Wada
openaire   +2 more sources

Decorin expression in quiescent myogenic cells

Biochemical and Biophysical Research Communications, 2008
Satellite cells are quiescent muscle stem cells that promote postnatal muscle growth and repair. When satellite cells are activated by myotrauma, they proliferate, migrate, differentiate, and ultimately fuse to existing myofibers. The remainder of these cells do not differentiate, but instead return to quiescence and remain in a quiescent state until ...
Takanori, Nishimura, Kenjiro, Nozu, Yasuhiro, Kishioka, Jun-Ichi, Wakamatsu, Akihito, Hattori   +4 more
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Affinity of Placental Decorin for Collagen

Bioscience, Biotechnology, and Biochemistry, 2000
Decorin was isolated from 7 M urea extract of bovine placental cotyledons by ion-exchange and hydrophobic chromatography. Decorin and its core protein showed a broad band at about 115 kDa and a single band at 47 kDa, respectively by SDS-PAGE. Anti-decorin core protein antiserum from pig skin was reacted with placental decorin and its core protein in ...
T, Batbayar, Y, Nomura, Y, Ishii, K, Shirai   +3 more
openaire   +2 more sources

Downregulation of Decorin and Transforming Growth Factor-β1 by Decorin Gene Suppression in Tendinocytes

Connective Tissue Research, 2005
Scars formed after tendonitis result in altered tissue mechanical properties after injury. The interaction of collagen molecules with decorin affects collagen fibrogenesis, and scar tissue is fragile as a consequence of a large amount of decorin in the scar.
Yoshinao, Hosaka, Rikio, Kirisawa, Naoki, Mafune, Kazushige, Takehana   +3 more
openaire   +2 more sources

Reconstruction of glycosaminoglycan chains in decorin

Biochemical and Biophysical Research Communications, 2002
The glycosaminoglycan chain of decorin from human spinal ligaments was digested using the hydrolysis of bovine testicular hyaluronidase. As a result, decorin with hexasaccharide, octasaccharide, and decasaccharide including the linkage region, GlcA-Gal-Gal-Xyl, was obtained.
Mito, Iwafune, Ikuko, Kakizaki, Masahiro, Yukawa, Daisuke, Kudo, Sakae, Ota, Masahiko, Endo, Keiichi, Takagaki   +6 more
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Decorin modulates matrix mineralization in vitro

Biochemical and Biophysical Research Communications, 2003
Decorin (DCN), a member of small leucine-rich proteoglycans, is known to modulate collagen fibrillogenesis. In order to investigate the potential roles of DCN in collagen matrix mineralization, several stable osteoblastic cell clones expressing higher (sense-DCN, S-DCN) and lower (antisense-DCN, As-DCN) levels of DCN were generated and the mineralized ...
Yoshiyuki, Mochida, Wagner R, Duarte, Hideki, Tanzawa, Eleftherios P, Paschalis, Mitsuo, Yamauchi   +4 more
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Differential interactions of decorin and decorin mutants with type I and type VI collagens

European Journal of Biochemistry, 2004
The small leucine‐rich proteoglycan decorin can bind via its core protein to different types of collagens such as type I and type VI. To test whether decorin can act as a bridging molecule between these collagens, the binding properties of wild‐type decorin, two full‐length decorin species with single amino acid substitutions (DCN E180K, DCN E180Q ...
Gordon, Nareyeck, Daniela G, Seidler, David, Troyer, Jürgen, Rauterberg, Hans, Kresse, Elke, Schönherr   +5 more
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Glomerular expression of biglycan and decorin and urinary levels of decorin in primary glomerular disease

Clinical Nephrology, 2004
Recent studies have suggested that small leucine-rich proteoglycans (SLRP) of the extracellular matrix play a major role in modulating the activity of growth factors and in regulating the deposition of collagens. In this study, the expression of the SLRPs biglycan and decorin in the glomeruli of patients with primary glomerular disease (minimal change ...
M, Kuroda, H, Sasamura, E, Kobayashi, R, Shimizu-Hirota, Y, Nakazato, M, Hayashi, T, Saruta   +6 more
openaire   +2 more sources

Structures of decorine and delcoridine

Chemistry of Natural Compounds, 1981
In order to confirm the structures of the alkaloids delcorine and delcoridine (O-demethyldelcorine) suggested previously, a direct passage has been performed from delcoridine to delcorine and from delcorine to delphatine. It has been shown that the α configuration of C1 - OCH3 previously suggested for delcorine and delcoridine is incorrect — it should ...
B. T. Salimov, M. G. Zhamierashvili, M. S. Yunusov   +2 more
openaire   +1 more source