Multi-Cancer Computational Analysis Reveals Metastasis-Associated Variant of Desmoplastic Reaction Involving INHBA and THBS2 [PDF]
, 2010 Despite extensive research, the details of the metastasis-associated biological mechanisms are largely unknown. Here, we analyze data from multiple cancers using a novel computational method identifying sets of genes whose coordinated overexpression ...
Dimitris Anastassiou +3 more
core +1 more source
British Journal of Pharmacology, 2018 Extracellular matrix (ECM) molecules play important roles in regulating processes such as cell proliferation, migration, differentiation and survival. Decorin is a proteoglycan that binds to (‘decorates’) collagen fibrils in the ECM.
T. Järvinen, E. Ruoslahti
semanticscholar +1 more source
Decorin‐mediated oncosuppression – a potential future adjuvant therapy for human epithelial cancers
British Journal of Pharmacology, 2018 Currently, the multifaceted role of the extracellular matrix (ECM) in tumourigenesis has been realized. One ECM macromolecule exhibiting potent oncosuppressive actions in tumourigenesis is decorin, the prototype of the small leucine‐rich proteoglycan ...
Annele Sainio, H. Järveläinen
semanticscholar +1 more source
Recombinant Decorin Glycoforms [PDF]
Journal of Biological Chemistry, 1996 Priya Ramamurthy +2 more
openaire +1 more source
Targeted Disruption of Decorin Leads to Abnormal Collagen Fibril Morphology and Skin Fragility
Journal of Cell Biology, 1997 Decorin is a member of the expanding group of widely distributed small leucine-rich proteoglycans that are expected to play important functions in tissue assembly.
K. Danielson +5 more
semanticscholar +1 more source
Decorin and TGF-β Expression after Partial Myotomy of the Extraocular Muscle in Rat [PDF]
, 2013 Young Jin Lim +4 more
openalex +1 more source
3Ds: decorin, discordance, and diamniotic dichorionic twins
Clinical and Experimental Obstetrics & Gynecology, 2017 aullimary Investigation: The cause of discordance in dichorionic diamniotic (DD) twins is still unknown. The authors aimed to compare decorin (DCN) and oxidative/antioxidative state levels between the placentas of discordant and concordant twins.Prospective study of 43 spontaneous DD twin pregnancies included and placentas samples taken from each twin ...
Ergin, M. +6 more
openaire +3 more sources
Decorin-inducible Peg3 Evokes Beclin 1-mediated Autophagy and Thrombospondin 1-mediated Angiostasis*
Journal of Biological Chemistry, 2017 We previously discovered that systemic delivery of decorin for treatment of breast carcinoma xenografts induces paternally expressed gene 3 (Peg3), an imprinted gene encoding a zinc finger transcription factor postulated to function as a tumor suppressor.
Annabel Torres +2 more
semanticscholar +1 more source
Increased expression of decorin in experimental hydronephrosis
Kidney International, 1997 Transforming growth factor (TGF)-beta1 is a potential mediator of tubulointerstitial (TI) fibrosis in the rat unilateral ureteral obstruction (UUO) model. Decorin is a protein composed of a core protein and a chondroitin sulfate side chain and is capable of inactivating TGF-beta.
Diamond, Jonathan R. +3 more
openaire +2 more sources
417. Intratumoral Delivery of Oncolytic Adenovirus Expressing Decorin Inhibits Growth and Metastases of 4T1 Breast Tumors in Syngeneic Immune Competent BALB/c Mice Model [PDF]
, 2016 Weidong Xu +10 more
openalex +1 more source