Results 11 to 20 of about 11,453 (186)
Determination of Dental Lesions in Dairy Cattle and Immunochemical Detection of the Biomarker Decorin in Gingival Crevicular Fluid of Dairy Cattle. [PDF]
Vet Med SciThis study identified dental and gingival lesions in dairy cattle, revealing the significance of routine periodontal assessment for animal welfare. Decorin levels in GCF samples were compared between healthy and diseased cattle, indicating its potential as a non‐invasive biomarker for dental inflammation.
Avci N.
europepmc +2 more sources
Focus on Molecules: Decorin [PDF]
Experimental Eye Research, 2011 Decorin (NM_133507) is a ubiquitous small extracellular proteoglycan. It is a composite molecule ~100kda in size with a protein core and attached GAGs. It was cloned from a human embryonic fibroblast line and named PG40 for its protein core, ~40Kda.
Shoujun, Chen, David E, Birk
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Oncosuppressive functions of decorin [PDF]
Molecular & Cellular Oncology, 2015 The extracellular matrix is rapidly emerging as a prominent contributor to various fundamental processes of tumorigenesis. In particular, decorin, a member of the small leucine-rich proteoglycan gene family, is assuming a central role as a potent soluble tumor repressor.
Neill, Thomas +2 more
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The American Journal of Pathology, 2012 Decorin, an archetypal member of the small leucine-rich proteoglycan gene family, has a broad binding repertoire that encompasses matrix structural components, such as collagens, and growth factors, particularly those that belong to the transforming growth factor-β ligand superfamily.
Neill, Thomas +2 more
openaire +4 more sources
Decorin Is a Zn2+ Metalloprotein [PDF]
Journal of Biological Chemistry, 1999 Decorin is ubiquitously distributed in the extracellular matrix of mammals and a member of the proteoglycan family characterized by a core protein dominated by leucine-rich repeat motifs. We show here that decorin extracted from bovine tissues under denaturing conditions or produced in recombinant "native" form by cultured mammalian cells has a high ...
V W, Yang +4 more
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Decorin Inhibits Dermal Mesenchymal Cell Migration and Induces Scar Formation
Plastic and Reconstructive Surgery, Global Open, 2022 Background:. Variations in skin healing capacities are observed during different murine embryonic developmental stages. Through embryonic day 16 (E16), embryos are able to regenerate dermal architecture following flank skin wounding; however, after E17 ...
Kento Takaya, MD +5 more
doaj +1 more source
Anti-fibrotic effect of decorin in peritoneal dialysis and PD-associated peritonitis
EBioMedicine, 2020 Background: Progressive peritoneal fibrosis is a common complication in patients on long-term peritoneal dialysis (PD). PD-associated peritonitis is a major exacerbating factor.
Na Jiang +9 more
doaj +1 more source
MicroRNA 181b regulates decorin production by dermal fibroblasts and may be a potential therapy for hypertrophic scar. [PDF]
PLoS ONE, 2015 Hypertrophic scarring is a frequent fibroproliferative complication following deep dermal burns leading to impaired function and lifelong disfigurement. Decorin reduces fibrosis and induces regeneration in many tissues, and is significantly downregulated
Peter Kwan, Jie Ding, Edward E Tredget
doaj +1 more source
Decorin knockdown is beneficial for aged tendons in the presence of biglycan expression
Matrix Biology Plus, 2022 Decorin and biglycan are two major small leucine-rich proteoglycans (SLRPs) present in the tendon extracellular matrix that facilitate collagen fibrillogenesis, tissue turnover, and cell signal transduction.
Zakary M. Beach +8 more
doaj +1 more source
npj Regenerative Medicine, 2023 Heart failure (HF) remains a global public health burden and often results following myocardial infarction (MI). Following injury, cardiac fibrosis forms in the myocardium which greatly hinders cellular function, survival, and recruitment, thus severely ...
Priya Mohindra +11 more
doaj +1 more source