Results 11 to 20 of about 29,996 (293)
Decorin as a multivalent therapeutic agent against cancer [PDF]
Advanced Drug Delivery Reviews, 2016 Decorin is a prototypical small leucine-rich proteoglycan that epitomizes the multifunctional nature of this critical gene family. Soluble decorin engages multiple receptor tyrosine kinases within the target-rich environment of the tumor stroma and tumor
Thomas Neill +2 more
exaly +3 more sources
Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia
Nature Communications, 2021 To elucidate the mechanisms underlying the reduced incidence of brain tumors in children with Neurofibromatosis type 1 (NF1) and asthma, we leverage Nf1 optic pathway glioma (Nf1OPG) mice, human and mouse RNAseq data, and two different experimental ...
Elizabeth Cordell +2 more
exaly +2 more sources
The effect of topical decorin on temporal changes to corneal immune cells after epithelial abrasion
Journal of Neuroinflammation, 2022 Background Corneal immune cells interact with corneal sensory nerves during both homeostasis and inflammation. This study sought to evaluate temporal changes to corneal immune cell density in a mouse model of epithelial abrasion and nerve injury, and to ...
Mengliang Wu +3 more
doaj +2 more sources
Decorin suppresses tumor lymphangiogenesis: A mechanism to curtail cancer progression [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaSignificance Decorin is a stromal proteoglycan with oncosuppressive functions, primarily by regulating several tyrosine kinase receptors involved in cancer growth and angiogenesis.
D. Mondal +4 more
semanticscholar +2 more sources
The Protective Role of Decorin in Hepatic Metastasis of Colorectal Carcinoma
Biomolecules, 2020 Decorin, the prototype member of the small leucine-rich proteoglycan gene family of extracellular matrix (ECM) proteins, acts as a powerful tumor suppressor by inducing the p21Waf1/Cip1 cyclin-dependent kinase inhibitor, as well as through its ability to
Andrea Reszegi +9 more
doaj +2 more sources
Protective Role of Decorin in Primary Hepatocellular Carcinoma
Frontiers in Oncology, 2020 Hepatocellular carcinoma (HCC) represents one of the most frequent type of primary liver cancers. Decorin, a small leucine-rich proteoglycan of the extracellular matrix, represents a powerful tumor cell growth and migration inhibitor by hindering ...
Andrea Reszegi +6 more
doaj +2 more sources
Decorin levels and cardiometabolic function after endurance exercise [PDF]
Frontiers in PhysiologyIntroductionDecorin is secreted from myotubes in response to exercise and plays a vital role in repairing and regenerate skeletal and cardiac muscle.
Antônio Alves de Fontes-Junior +4 more
doaj +2 more sources
ACS Nano, 2019 Joint biomechanical functions rely on the integrity of cartilage extracellular matrix. Understanding the molecular activities that govern cartilage matrix assembly is critical for developing effective cartilage regeneration strategies.
Biao Han, Hadi T Nia, Christopher Li
exaly +2 more sources
The neuroregenerative effects of topical decorin on the injured mouse cornea
Journal of Neuroinflammation, 2020 Background The cornea is innervated with a rich supply of sensory nerves that play important roles in ocular surface health. Any injury or pathology of the corneal nerves increases the risk of dry eye disease and infection.
Mengliang Wu +8 more
doaj +2 more sources
The Preventive Effect of Decorin on Epidural Fibrosis and Epidural Adhesions After Laminectomy
Frontiers in Pharmacology, 2021 Laminectomy is commonly performed to treat degenerative spinal diseases by reducing compression on the spinal cord and nerve roots. The postoperative epidural fibrosis and epidural adhesions may result in failed back surgery syndrome, which is ...
Qing Ding +11 more
doaj +2 more sources