Results 21 to 30 of about 11,453 (186)
Human Metaplastic Breast Carcinoma and Decorin [PDF]
Cancer Microenvironment, 2017 Metaplastic breast carcinoma (MBC) is a rare subtype of invasive breast cancer and has poor prognosis. In general, cancers are heterogeneous cellular masses comprised of different cell types and their extracellular matrix (ECM). However, little is known about the composition of the ECM and its constituents in MBC.
Pia Boström +6 more
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Journal of Experimental & Clinical Cancer Research, 2023 Background The interplay between gut microbiota and tumor microenvironment (TME) in the pathogenesis of colorectal cancer (CRC) is largely unknown. Here, we elucidated the functional role of B.
Yifeng Lin +7 more
doaj +1 more source
Frontiers in Oncology, 2021 Decorin exhibits inhibitory effects in tumorigenesis in various types of cancers. The clinical characteristics of 42 patients with GBM were reviewed and analyzed.
Yanfei Jia +6 more
doaj +1 more source
Decorin Modulates Fibrin Assembly and Structure [PDF]
Journal of Biological Chemistry, 2006 Emerging evidence indicates that fibrin clotting is regulated by different external factors. We demonstrated recently that decorin, a regulator of collagen fibrillogenesis and transforming growth factor-beta activity, binds to the D regions of fibrinogen (Dugan, T.A., Yang, V. W.-C., McQuillan, D.J., and Höök, M. (2003) J. Biol. Chem. 278, 13655-13662).
Tracey A, Dugan +3 more
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Therapeutic Advances in Cardiovascular Disease, 2011 Atherosclerotic cardiovascular disease is a major cause of morbidity and mortality in the Western world. Despite tremendous strides in understandings its pathogenesis, it still remains a challenge because of gaps in our understanding of its initiation, progression and complications leading to the clinical syndromes of angina, acute coronary syndrome ...
Sandeep, Singla +3 more
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Indian Journal of Pathology and Microbiology, 2013 Background: Decorin is an extracellular matrix, multifunctional small proteoglycan molecule in tumor stroma that has been shown to be modulator of angiogenesis.
Seema Nayak +8 more
doaj +1 more source
Pivotal role for decorin in angiogenesis [PDF]
Matrix Biology, 2015 Angiogenesis, the formation of new blood vessels from preexisting vessels, is a highly complex process. It is regulated in a finely-tuned manner by numerous molecules including not only soluble growth factors such as vascular endothelial growth factor and several other growth factors, but also a diverse set of insoluble molecules, particularly ...
Hannu, Järveläinen +2 more
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The Scientific World Journal, 2006 The small leucine-rich proteoglycan (SLRP) decorin is efficiently internalized by a variety of cultured cells. A 51-kDa protein has previously been described as a receptor mediating endocytosis of decorin and of the structurally related SLRP biglycan ...
David Denis Sofeu Feugaing +3 more
doaj +1 more source
Solar ultraviolet irradiation induces decorin degradation in human skin likely via neutrophil elastase. [PDF]
PLoS ONE, 2013 Exposure of human skin to solar ultraviolet (UV) irradiation induces matrix metalloproteinase-1 (MMP-1) activity, which degrades type I collagen fibrils. Type I collagen is the most abundant protein in skin and constitutes the majority of skin connective
Yong Li +5 more
doaj +1 more source
Protective Role of Decorin in Primary Hepatocellular Carcinoma
Frontiers in Oncology, 2020 Hepatocellular carcinoma (HCC) represents one of the most frequent type of primary liver cancers. Decorin, a small leucine-rich proteoglycan of the extracellular matrix, represents a powerful tumor cell growth and migration inhibitor by hindering ...
Andrea Reszegi +6 more
doaj +1 more source