Results 21 to 30 of about 29,996 (293)

Effect of Decorin and Aligned Collagen Fibril Topography on TGF-β1 Activation of Corneal Keratocytes [PDF]

Bioengineering
During corneal wound healing, transforming growth factor-beta 1 (TGF-β1) causes differentiation of quiescent keratocytes into myofibroblasts. Decorin has been investigated as a promising anti-fibrotic therapeutic for corneal healing due to its ...
Nathaniel S. Tjahjono, Divya Subramanian, Tarik Z. Shihabeddin, Hudson D. Hicks, Victor D. Varner, W. Matthew Petroll, David W. Schmidtke   +6 more
doaj   +2 more sources

Compensatory fetal membrane mechanisms between biglycan and decorin in inflammation. [PDF]

, 2015
Preterm premature rupture of fetal membranes (PPROM) is associated with infection, and is one of the most common causes of preterm birth. Abnormal expression of biglycan and decorin, two extracellular matrix proteoglycans, leads to preterm birth and ...
Aron, Abraham, de Miranda de Araujo, Luciana Batalha, Horgan, Casie E, Iozzo, Renato V., Lechner, Beatrice E   +4 more
core   +3 more sources

Decreased Serum Decorin Levels Are Correlated with Aortic Stiffness as Assessed Using Carotid–Femoral Pulse Wave Velocity in Patients with Peritoneal Dialysis [PDF]

Life
In patients on chronic peritoneal dialysis (PD), aortic stiffness (AS) is a common cardiovascular condition that can predict cardiovascular events and mortality. Decorin is a small leucine-rich proteoglycan that plays a vital role in extracellular matrix
Yahn-Bor Chern, Po-Yu Huang, Yu-Li Lin, Chih-Hsien Wang, Jen-Pi Tsai, Bang-Gee Hsu   +5 more
doaj   +2 more sources

Decorin Deficiency Promotes D‐Galactose–Induced Skeletal Muscle Atrophy and Fibrosis by Regulating ITGB1/Akt/mTOR Signalling Pathway [PDF]

Journal of Cachexia, Sarcopenia and Muscle
Background Primary sarcopenia is an age‐associated disorder with progressive and generalised loss of skeletal muscle strength and mass. Skeletal muscle fibrosis is one of the significant pathological manifestations of age‐associated sarcopenia.
Xiaoqin Luo, Mengxue Zhang, Lili Chen, Ruichang Wang, Jiabing Lian, Zhe Yang, Renato V. Iozzo, Jin Wang, Yan Zhang, Xiuli Bi   +9 more
doaj   +2 more sources

Decorin deficiency promotes hepatic carcinogenesis [PDF]

Matrix Biology, 2015
Hepatocellular carcinoma represents one of the most-rapidly spreading cancers in the world. In the majority of cases, an inflammation-driven fibrosis or cirrhosis precedes the development of the tumor.
Alexandra Fullár, Araki, Baghy, Baghy, Becker, Berasain, Bertino, Bi, Bi, Bradford, Brandan, Buraschi, Buraschi, Buraschi, Camus-Randon, Chen, Chen, Chen, Cho, Csordas, Dahmani, Daley, Danielson, Danilkovitch-Miagkova, De Luca, Dudas, Dunkman, El-Serag, Farber, Ferdous, Goldoni, Goldoni, Grimes, Guo, Harper, Harper, He, Heindryckx, Hielscher, Hu, Hu, Hynes, Ichii, Ilona Kovalszky, Iozzo, Iozzo, Iozzo, Iozzo, Iozzo, Iozzo, Iozzo, Iozzo, Jacobs, Jain, Jarvelainen, Jung, Katalin Kiss, Khan, Kornélia Baghy, Lee, Lempinen, Li, Llovet, Loeppen, Lu, Marastoni, Merline, Morrione, Neill, Neill, Neill, Nikitovic, Nystrom, Okazaki, Oseini, Reed, Reed, Reed, Renato V. Iozzo, Rivadeneira, Robinson, Rozario, Ruoslahti, Santra, Schaefer, Schaefer, Schonherr, Seidler, Seidler, Seidler, Sengupta, Sherman, Sofeu Feugaing, Stock, Tralhao, Villanueva, Whittaker, Wu, Yamaguchi, Zhang, Zhang, Zhu, Zsolt Horváth, Zsuzsa Schaff   +103 more
core   +4 more sources

Serum decorin and biglycan levels as predictive biomarkers for lung fibrosis severity and mortality risk in COVID-19 patients [PDF]

Frontiers in Medicine
IntroductionIndividuals experiencing severe symptoms of COVID-19 are at the greatest risk of developing post-COVID lung fibrosis, which significantly impacts long-term health outcomes.
Shaaf Ahmad, Kaleem Maqsood, Farwa Liaqat, Nabila Roohi   +3 more
doaj   +2 more sources

Corrigendum to "Decorin deficiency promotes epithelial-mesenchymal transition and colon cancer metastasis" [Matrix Biology Volume 95 (2021)1-14]. [PDF]

Matrix Biol
Mao L, Yang J, Yue J, Chen Y, Zhou H, Fan D, Zhang Q, Buraschi S, Iozzo RV, Bi X.   +9 more
europepmc   +3 more sources

CANT1 Is Involved in Collagen Fibrogenesis in Tendons by Regulating the Synthesis of Dermatan/Chondroitin Sulfate Attached to the Decorin Core Protein. [PDF]

Int J Mol Sci
Yamashita R, Tsutsui S, Mizumoto S, Watanabe T, Yamamoto N, Nakano K, Yamada S, Okamura T, Furuichi T.   +8 more
europepmc   +3 more sources

Decorin Regulates Cartilage Pericellular Matrix Micromechanobiology.

Matrix Biology, 2020
In cartilage tissue engineering, one key challenge is for regenerative tissue to recapitulate the biomechanical functions of native cartilage while maintaining normal mechanosensitive activities of chondrocytes. Thus, it is imperative to discern the micromechanobiological functions of the pericellular matrix, the ~ 2-4 µm-thick domain that is in ...
Daphney Chery, B. Han, Ying Zhou, Chao Wang, Sheila Adams, P. Chandrasekaran, B. Kwok, S. Heo, M. Enomoto-Iwamoto, X. L. Lu, Dehan Kong, Renato V. Iozzo, David E. Birk, Robert L. Mauck, Lin Han   +14 more
semanticscholar   +4 more sources

Decorin and biglycan are necessary for maintaining collagen fibril structure, fiber realignment, and mechanical properties of mature tendons

Matrix Biology, 2017
Mei Sun, Renato V Iozzo, Louis J Soslowsky   +2 more
exaly   +2 more sources