Results 31 to 40 of about 11,453 (186)

Immunostaining for VEGF and Decorin Predicts Poor Survival and Recurrence in Canine Soft Tissue Sarcoma

Veterinary Sciences, 2023
The aim of this study was to investigate whether using immunohistochemistry to detect the angiogenic proteins vascular endothelial growth factor (VEGF) and decorin can help predict the risk of local recurrence of, or death from, canine soft tissue ...
Jonathan P. Bray, Matthew R. Perrott, John S. Munday   +2 more
doaj   +1 more source

Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosis

Acta Neuropathologica Communications, 2022
Cerebrospinal fluid (CSF) biomarkers play an important role in diagnosing Alzheimer’s disease (AD) which is characterized by amyloid-β (Aβ) amyloidosis. Here, we used two App knock-in mouse models, App NL-F/NL-F and App NL-G-F/NL-G-F , exhibiting AD-like
Richeng Jiang, Una Smailovic, Hazal Haytural, Betty M. Tijms, Hao Li, Robert Mihai Haret, Ganna Shevchenko, Gefei Chen, Axel Abelein, Johan Gobom, Susanne Frykman, Misaki Sekiguchi, Ryo Fujioka, Naoto Watamura, Hiroki Sasaguri, Sofie Nyström, Per Hammarström, Takaomi C. Saido, Vesna Jelic, Stina Syvänen, Henrik Zetterberg, Bengt Winblad, Jonas Bergquist, Pieter Jelle Visser, Per Nilsson   +24 more
doaj   +1 more source

Role of Decorin in the Lens and Ocular Diseases

Cells, 2022
Decorin is an archetypal member of the small leucine-rich proteoglycan gene family and is involved in various biological functions and many signaling networks, interacting with extra-cellular matrix (ECM) components, growth factors, and receptor tyrosine
Eri Kubo, Shinsuke Shibata, Teppei Shibata, Hiroshi Sasaki, Dhirendra P. Singh   +4 more
doaj   +1 more source

Decorin deficiency promotes hepatic carcinogenesis

Matrix Biology, 2014
Hepatocellular carcinoma represents one of the most-rapidly spreading cancers in the world. In the majority of cases, an inflammation-driven fibrosis or cirrhosis precedes the development of the tumor. During malignant transformation, the tumor microenvironment undergoes qualitative and quantitative changes that modulate the behavior of the malignant ...
Horváth, Zsolt, Kovalszky, Ilona, Fullár, Alexandra, Kiss, Katalin, Schaff, Zsuzsa, Iozzo RV, Baghy, Kornélia   +6 more
openaire   +3 more sources

The Role of Decorin in Autoimmune and Inflammatory Diseases

Journal of Immunology Research, 2022
Decorin is an extracellular matrix protein that belongs to the family of small leucine-rich proteoglycans. As a matrix protein, the first discovered role of decorin is participating in collagen fibril formation. Many other functions of decorin in various
Yuanji Dong, Jixin Zhong, Lingli Dong
doaj   +1 more source

Binding of tenascin‐X to decorin

FEBS Letters, 2001
Tenascin‐X (TN‐X) is an extracellular matrix protein whose absence results in an alteration of the mechanical properties of connective tissue. To understand the mechanisms of integration of TN‐X in the extracellular matrix, overlay blot assays were performed on skin extracts.
Elefteriou, Florent, Exposito, Jean-Yves, Garrone, Robert, Lethias, Claire   +3 more
openaire   +2 more sources

Biological functions of decorin in cancer [PDF]

Chinese Journal of Cancer, 2013
Decorin is a member of the extracellular matrix small leucine-rich proteoglycans family that exists and functions in stromal and epithelial cells. Accumulating evidence suggests that decorin affects the biology of various types of cancer by directly or indirectly targeting the signaling molecules involved in cell growth, survival, metastasis, and ...
Bi, Xiu-Li, Yang, Wancai
openaire   +2 more sources

Targeted decorin gene therapy delivered with adeno-associated virus effectively retards corneal neovascularization in vivo. [PDF]

PLoS ONE, 2011
Decorin, small leucine-rich proteoglycan, has been shown to modulate angiogenesis in nonocular tissues. This study tested a hypothesis that tissue-selective targeted decorin gene therapy delivered to the rabbit stroma with adeno-associated virus serotype
Rajiv R Mohan, Jonathan C K Tovey, Ajay Sharma, Gregory S Schultz, John W Cowden, Ashish Tandon   +5 more
doaj   +1 more source

Myopathy Associated With Dermatan Sulfate-Deficient Decorin and Myostatin in Musculocontractural Ehlers-Danlos Syndrome: A Mouse Model Investigation

Frontiers in Cell and Developmental Biology, 2021
Carbohydrate sulfotransferase 14 (CHST14) encodes dermatan 4-O-sulfotransferase 1, a critical enzyme for dermatan sulfate (DS) biosynthesis. Musculocontractural Ehlers-Danlos syndrome (mcEDS) is associated with biallelic pathogenic variants of CHST14 and
Yuko Nitahara-Kasahara, Yuko Nitahara-Kasahara, Guillermo Posadas-Herrera, Shuji Mizumoto, Aki Nakamura-Takahashi, Yukiko U. Inoue, Takayoshi Inoue, Yoshihiro Nomura, Shin’ichi Takeda, Shuhei Yamada, Tomoki Kosho, Tomoki Kosho, Tomoki Kosho, Tomoki Kosho, Takashi Okada   +14 more
doaj   +1 more source

Decorin treatment of spinal cord injury

Neural Regeneration Research, 2014
The scarring response after a penetrant central nervous system injury results from the interaction between invading leptominingeal/pericyte-derived fibroblasts and endogenous reactive astrocytes about the wound margin. Extracellular matrix and scar-derived axon growth inhibitory molecules fill the lesion site providing both a physical and chemical ...
Esmaeili, Maryam, Berry, Martin, Logan, Ann, Ahmed, Zubair   +3 more
openaire   +2 more sources