Results 31 to 40 of about 29,996 (293)

Decorin promotes decidual M1-like macrophage polarization via mitochondrial dysfunction resulting in recurrent pregnancy loss

Theranostics, 2022
Rationale: Recurrent pregnancy loss (RPL) is a distressing disorder that seriously affects the physical and psychological health of women. RPL is also a sentinel risk marker for future obstetric complications and warrants in-depth investigation. Abnormal
Liling Wang, Huan Wang, Jing Luo, Ting Xie, G. Mor, A. Liao   +5 more
semanticscholar   +1 more source

Oncosuppressive roles of decorin through regulation of multiple receptors and diverse signaling pathways.

American Journal of Physiology - Cell Physiology, 2022
Decorin is a stromal-derived prototype member of the small leucine-rich proteoglycan gene family. In addition to its functions as a regulator of collagen fibrillogenesis and TGFb activity, soluble decorin acts as a pan-receptor tyrosine kinase (RTK ...
C. Xie, D. Mondal, Mikdat Ulas, T. Neill, R. Iozzo   +4 more
semanticscholar   +1 more source

Lack of decorin expression by human bladder cancer cells offers new tools in the therapy of urothelial malignancies. [PDF]

PLoS ONE, 2013
Decorin, a multifunctional small leucine-rich extracellular matrix proteoglycan, has been shown to possess potent antitumour activity. However, there is some uncertainty whether different cancer cells express decorin in addition to non-malignant stromal ...
Annele Sainio, Marie Nyman, Riikka Lund, Sanna Vuorikoski, Pia Boström, Matti Laato, Peter J Boström, Hannu Järveläinen   +7 more
doaj   +1 more source

Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer

Communications Biology, 2021
Inflammatory breast cancer (IBC) is a clinically distinct and highly aggressive form of breast cancer with rapid onset and a strong propensity to metastasize.
Xiaoding Hu, E. Villodre, R. Larson, Omar M. Rahal, Xiaoping Wang, Y. Gong, Juhee Song, S. Krishnamurthy, N. Ueno, D. Tripathy, W. Woodward, B. Debeb   +11 more
semanticscholar   +1 more source

The Role of Decorin and Biglycan Signaling in Tumorigenesis

Frontiers in Oncology, 2021
The complex and adaptive nature of malignant neoplasm constitute a major challenge for the development of effective anti-oncogenic therapies. Emerging evidence has uncovered the pivotal functions exerted by the small leucine-rich proteoglycans, decorin ...
Valentina Diehl, L. Huber, J. Trebicka, M. Wygrecka, R. Iozzo, L. Schaefer   +5 more
semanticscholar   +1 more source

Focus on Molecules: Decorin [PDF]

Experimental Eye Research, 2011
Decorin (NM_133507) is a ubiquitous small extracellular proteoglycan. It is a composite molecule ~100kda in size with a protein core and attached GAGs. It was cloned from a human embryonic fibroblast line and named PG40 for its protein core, ~40Kda.
Shoujun, Chen, David E, Birk
openaire   +2 more sources

Decorin knockdown is beneficial for aged tendons in the presence of biglycan expression

Matrix Biology Plus, 2022
Decorin and biglycan are two major small leucine-rich proteoglycans (SLRPs) present in the tendon extracellular matrix that facilitate collagen fibrillogenesis, tissue turnover, and cell signal transduction.
Zakary M. Beach, Mihir S. Dekhne, Ashley B. Rodriguez, Stephanie N. Weiss, Thomas H. Adams, Sheila M. Adams, Mei Sun, David E. Birk, Louis J. Soslowsky   +8 more
doaj   +1 more source

Resistance Exercise-Induced Increases in Muscle Myostatin mRNA and Protein Expression Are Subsequently Decreased in Circulation in the Presence of Increased Levels of the Extracellular Matrix Stabilizing Protein Decorin.

Journal of Sports Science and Medicine, 2022
Resistance exercise (RE) activates cell signaling pathways associated with myostatin. Decorin is located in the extracellular matrix (ECM) and can block the inhibitory effect of myostatin.
D. Willoughby, T. Cardaci, Steven B. Machek, Dylan T. Wilburn, J. Heileson   +4 more
semanticscholar   +1 more source

Oncosuppressive functions of decorin [PDF]

Molecular & Cellular Oncology, 2015
The extracellular matrix is rapidly emerging as a prominent contributor to various fundamental processes of tumorigenesis. In particular, decorin, a member of the small leucine-rich proteoglycan gene family, is assuming a central role as a potent soluble tumor repressor.
Neill, Thomas, Schäfer, Liliana, Iozzo, Renato V.   +2 more
openaire   +4 more sources

The Role of Decorin Proteoglycan in Mitophagy

Cancers, 2022
Simple Summary The eminent rise of extracellular matrix constituents, chiefly hailing from the proteoglycan gene family, has revolutionized our understanding of how intracellular catabolism is regulated at the intersection of autophagy and breast cancer.
T. Neill, R. Iozzo
semanticscholar   +1 more source