Results 41 to 50 of about 29,996 (293)

Decorin

The American Journal of Pathology, 2012
Decorin, an archetypal member of the small leucine-rich proteoglycan gene family, has a broad binding repertoire that encompasses matrix structural components, such as collagens, and growth factors, particularly those that belong to the transforming growth factor-β ligand superfamily.
Neill, Thomas, Schaefer, Liliana, Iozzo, Renato V.   +2 more
openaire   +4 more sources

Overexpression of decorin gene influences the biological behaviors of follicular thyroid carcinoma cells. [PDF]

Oncol Lett
Lin Q, Ma Y, Guo R, Guo H, Wang X, Yang T.   +5 more
europepmc   +3 more sources

Bone marrow plasma level of decorin may be associated with improved treatment outcomes in a subset of multiple myeloma patients

Journal of the Formosan Medical Association, 2022
Background/purpose: Decorin is a small leucine-rich proteoglycan rich in extracellular matrix with potential antitumor activity. However, the role of decorin in hematological malignancies remains unclear, especially in the case of multiple myeloma (MM ...
Shang-Yi Huang, Hsiu-Hsia Lin, Ming Yao, Jih-Luh Tang, Shang-Ju Wu, Wen-Chien Chou, Szu-Chun Hsu, Bor-Sheng Ko, Hwei-Fang Tien   +8 more
doaj   +1 more source

Determination of Dental Lesions in Dairy Cattle and Immunochemical Detection of the Biomarker Decorin in Gingival Crevicular Fluid of Dairy Cattle [PDF]

Vet Med Sci
This study identified dental and gingival lesions in dairy cattle, revealing the significance of routine periodontal assessment for animal welfare. Decorin levels in GCF samples were compared between healthy and diseased cattle, indicating its potential as a non‐invasive biomarker for dental inflammation.
AVCI N.
europepmc   +2 more sources

Decorin Is a Zn2+ Metalloprotein [PDF]

Journal of Biological Chemistry, 1999
Decorin is ubiquitously distributed in the extracellular matrix of mammals and a member of the proteoglycan family characterized by a core protein dominated by leucine-rich repeat motifs. We show here that decorin extracted from bovine tissues under denaturing conditions or produced in recombinant "native" form by cultured mammalian cells has a high ...
V W, Yang, S R, LaBrenz, L C, Rosenberg, D, McQuillan, M, Höök   +4 more
openaire   +2 more sources

Anti-fibrotic effect of decorin in peritoneal dialysis and PD-associated peritonitis

EBioMedicine, 2020
Background: Progressive peritoneal fibrosis is a common complication in patients on long-term peritoneal dialysis (PD). PD-associated peritonitis is a major exacerbating factor.
Na Jiang, Qing Zhang, Mel KM Chau, Ming S Yip, Sing Leung Lui, Stephanie Liu, Kent Man Chu, Hextan YS Ngan, Tak Mao Chan, Susan Yung   +9 more
doaj   +1 more source

Cancer-Associated Fibroblasts Promote Vascular Invasion of Hepatocellular Carcinoma via Downregulating Decorin-integrin β1 Signaling

Frontiers in Cell and Developmental Biology, 2021
Hepatocellular carcinoma (HCC) is a common malignancy worldwide, and the high ratio of recurrence and metastasis remains the main cause of its poor prognosis. Vascular invasion of HCC includes microvascular invasion (MVI) and portal vein tumor thrombosis
Xiaobo Zheng, Peng Wang, Li Li, Jing Yu, Chune Yu, Liangliang Xu, Lian Li, Fuzhen Dai, Lei Feng, Hong-Bo Zou, Xiaobo Chen, Ming Zhang, Mingqing Xu   +12 more
semanticscholar   +1 more source

Decorin Inhibits Dermal Mesenchymal Cell Migration and Induces Scar Formation

Plastic and Reconstructive Surgery, Global Open, 2022
Background:. Variations in skin healing capacities are observed during different murine embryonic developmental stages. Through embryonic day 16 (E16), embryos are able to regenerate dermal architecture following flank skin wounding; however, after E17 ...
Kento Takaya, MD, Noriko Aramaki-Hattori, MD, PhD, Shigeki Sakai, MD, PhD, Keisuke Okabe, MD, PhD, Toru Asou, PD, PhD, Kazuo Kishi, MD, PhD   +5 more
doaj   +1 more source

Selective inactivity of TGF‐β/decorin complexes [PDF]

FEBS Letters, 1994
Previous studies had shown that binding of TGF‐β to the small proteoglycan decorin results in its inactivation. Indeed, in osteosarcoma cells the addition of decorin prevented the TGF‐β1‐mediated up‐regulation of biglycan synthesis. However, the down‐regulation of proteoglycan‐100 remained unaltered.
Heinz Hausser, Arndt Gröning, Andrej Hasilík, Elke Schönherr, Hans Kresse   +4 more
openalex   +4 more sources

MicroRNA 181b regulates decorin production by dermal fibroblasts and may be a potential therapy for hypertrophic scar. [PDF]

PLoS ONE, 2015
Hypertrophic scarring is a frequent fibroproliferative complication following deep dermal burns leading to impaired function and lifelong disfigurement. Decorin reduces fibrosis and induces regeneration in many tissues, and is significantly downregulated
Peter Kwan, Jie Ding, Edward E Tredget
doaj   +1 more source