Results 61 to 70 of about 29,996 (293)
The Scientific World Journal, 2006 The small leucine-rich proteoglycan (SLRP) decorin is efficiently internalized by a variety of cultured cells. A 51-kDa protein has previously been described as a receptor mediating endocytosis of decorin and of the structurally related SLRP biglycan ...
David Denis Sofeu Feugaing +3 more
doaj +1 more source
Solar ultraviolet irradiation induces decorin degradation in human skin likely via neutrophil elastase. [PDF]
PLoS ONE, 2013 Exposure of human skin to solar ultraviolet (UV) irradiation induces matrix metalloproteinase-1 (MMP-1) activity, which degrades type I collagen fibrils. Type I collagen is the most abundant protein in skin and constitutes the majority of skin connective
Yong Li +5 more
doaj +1 more source
Targeting danger molecules in tendinopathy: the HMGB1/TLR4 axis [PDF]
, 2017 Objectives: To seek evidence of the danger molecule, high-mobility group protein B1 (HMGB1) expression in human tendinopathy and thereafter, to explore mechanisms where HMGB1 may regulate inflammatory mediators and matrix regulation in human tendinopathy.
Akbar, Moeed +10 more
core +1 more source
Veterinary Sciences, 2023 The aim of this study was to investigate whether using immunohistochemistry to detect the angiogenic proteins vascular endothelial growth factor (VEGF) and decorin can help predict the risk of local recurrence of, or death from, canine soft tissue ...
Jonathan P. Bray +2 more
doaj +1 more source
IGF-1 Upregulates Biglycan and Decorin by Increasing Translation and Reducing ADAMTS5 Expression
International Journal of Molecular Sciences, 2021 Proteoglycan (PG) is a glycosaminoglycan (GAG)-conjugated protein essential for maintaining tissue strength and elasticity. The most abundant skin PGs, biglycan and decorin, have been reported to decrease as skin ages. Insulin-like growth factor-1 (IGF-1)
Hanon Lee +4 more
semanticscholar +1 more source
Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-cadherin in vitro and in mice. [PDF]
, 2011 Previous studies have shown that decorin expression is significantly reduced in colorectal cancer tissues and cancer cells, and genetic deletion of the decorin gene is sufficient to cause intestinal tumor formation in mice, resulting from a ...
Bi, Xiuli +8 more
core +2 more sources
Targeted decorin gene therapy delivered with adeno-associated virus effectively retards corneal neovascularization in vivo. [PDF]
PLoS ONE, 2011 Decorin, small leucine-rich proteoglycan, has been shown to modulate angiogenesis in nonocular tissues. This study tested a hypothesis that tissue-selective targeted decorin gene therapy delivered to the rabbit stroma with adeno-associated virus serotype
Rajiv R Mohan +5 more
doaj +1 more source
Decorin suppresses tumor cell-mediated angiogenesis [PDF]
Oncogene, 2002 The progressive growth of most neoplasms is dependent upon the establishment of new blood vessels, a process regulated by tumor-secreted factors and matrix proteins. We examined the in vitro and in vivo angiogenic ability of conditioned media obtained from fibrosarcoma, carcinoma, and osteosarcoma cells and their decorin-transfected counterparts. Human
Derrick S, Grant +5 more
openaire +2 more sources
Decorin transfection induces proteomic and phenotypic modulation in breast cancer cells 8701-BC [PDF]
, 2008 Decorin is a prototype member of the small leucine-rich proteoglycan family widely distributed in the extracellular matrices of many connective tissues, where it has been shown to play multiple important roles in the matrix assembly process, as well as ...
Cancemi P +10 more
core +1 more source
Study on the expression profile and role of decorin in the progression of pancreatic cancer
Aging, 2021 Desmoplasia in the extracellular matrix (ECM) is one of the hallmarks of pancreatic cancer (PC), a virtually incurable disease. Decorin, a classical small leucine-rich proteoglycan found in the ECM, was upregulated in PC tissue samples according to the ...
Litao Zhang +9 more
semanticscholar +1 more source