Results 71 to 80 of about 11,453 (186)

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

New insight of some extracellular matrix molecules in beef muscles. Relationships with sensory qualities

Animal, 2016
The aim of this study was to highlight the relationships between decorin, tenascin-X and type XIV collagen, three minor molecules of extracellular matrix (ECM), with some structural parameters of connective tissue and its content in total collagen, its ...
A. Dubost, D. Micol, C. Lethias, A. Listrat   +3 more
doaj   +1 more source

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

Decorin Protects Cardiac Myocytes against Simulated Ischemia/Reperfusion Injury

Molecules, 2020
Search for new cardioprotective therapies is of great importance since no cardioprotective drugs are available on the market. In line with this need, several natural biomolecules have been extensively tested for their potential cardioprotective effects ...
Renáta Gáspár, Kamilla Gömöri, Bernadett Kiss, Ágnes Szántai, János Pálóczi, Zoltán V. Varga, Judit Pipis, Barnabás Váradi, Bence Ágg, Tamás Csont, Péter Ferdinandy, Monika Barteková, Anikó Görbe   +12 more
doaj   +1 more source

Assessment of two minimally invasive methodologies for sex identification in the European eel, Anguilla anguilla

Journal of Fish Biology, EarlyView.
Abstract Sex is an important driver of variation in behaviour, ecology and physiology. Sex identification in the Critically Endangered European eel (Anguilla anguilla) currently requires fish sacrifice, or the use of morphological differences such as body length, which can be inaccurate in certain habitats and at intermediate body lengths.
Michael J. Williamson, Jack A. Brand, Kevin Hopkins, Luke O'Connor, Matthew W. Perkins, Christopher Sergeant, Simon Spiro, Taina Strike, Jessica Whinfield, Rosie S. Williams, Ethan Wrigglesworth, Rosalind M. Wright, Adam T. Piper   +12 more
wiley   +1 more source

Treating age‐related loss of muscle mass and function: Where should we be focusing?

The Journal of Physiology, EarlyView.
Abstract figure legend Perturbations contributing to the age‐related loss of muscle mass and strength. A, in the spinal cord, self‐reinforcing cycles of oxidative stress, mitochondrial dysfunction and inflammation mediated by cells, including microglia, contribute to motor neuron degeneration.
Daniel J. Ham, Christopher S. Fry, Avnika Ashok Ruparelia, Shyuan T. Ngo, Séverine Lamon   +4 more
wiley   +1 more source

Effect of human myoblasts on tenogenic progression in 2D and 3D culture models

Journal of Anatomy, Volume 248, Issue 4, Page 653-663, April 2026.
We investigated whether factors released from muscle derived myogenic cells enhance tenogenic progressions of human tendon derived cells using two‐dimensional (2D) culture model and a three‐dimensional (3D)‐engineered tendon construct culture model.
Yoshifumi Tsuchiya, Ching‐Yan Chloé Yeung, Rene B. Svensson, Michael Kjaer   +3 more
wiley   +1 more source

Cathepsin-S degraded decorin are elevated in fibrotic lung disorders – development and biological validation of a new serum biomarker

BMC Pulmonary Medicine, 2017
Background Decorin is one of the most abundant proteoglycans of the extracellular matrix and is mainly secreted and deposited in the interstitial matrix by fibroblasts where it plays an important role in collagen turnover and tissue homeostasis ...
S.N. Kehlet, C.L. Bager, N. Willumsen, B. Dasgupta, C. Brodmerkel, M. Curran, S. Brix, D.J. Leeming, M. A. Karsdal   +8 more
doaj   +1 more source

Inflammation in Idiopathic Intracranial Hypertension: An Immunometabolic Mechanistic Framework and Clinical Implications

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Systemic metabolic dysfunction and comorbidities may act as upstream modulators converging on inflammatory activation, which is closely intertwined with excessive CSF production and impaired clearance, potentially contributing to sustained ICP elevation.
Guangyu Han, Jiahao Song, Shuling Wan, Xunming Ji, Da Zhou, Ran Meng   +5 more
wiley   +1 more source

Inclusion of Chondroitin Sulfate Into a Gelatin Hydrogel Shifts Local and Global Mechanical Behavior and Fibrochondrogenic Phenotype for Applications in Insertional Tissue Engineering

Journal of Biomedical Materials Research Part A, Volume 114, Issue 3, March 2026.
ABSTRACT Glycosaminoglycans (GAGs) like chondroitin sulfate (CS) influence both mechanical properties and biological signals within the tissue microenvironment. CS modifications have been prevalent in a range of biomaterial design strategies, particularly those with a focus on wound healing.
Kyle B. Timmer, Michael Xu, Brendan A. C. Harley   +2 more
wiley   +1 more source