Results 71 to 80 of about 29,996 (293)

Binding of tenascin‐X to decorin

FEBS Letters, 2001
Tenascin‐X (TN‐X) is an extracellular matrix protein whose absence results in an alteration of the mechanical properties of connective tissue. To understand the mechanisms of integration of TN‐X in the extracellular matrix, overlay blot assays were performed on skin extracts.
Elefteriou, Florent, Exposito, Jean-Yves, Garrone, Robert, Lethias, Claire   +3 more
openaire   +2 more sources

Biological functions of decorin in cancer [PDF]

Chinese Journal of Cancer, 2013
Decorin is a member of the extracellular matrix small leucine-rich proteoglycans family that exists and functions in stromal and epithelial cells. Accumulating evidence suggests that decorin affects the biology of various types of cancer by directly or indirectly targeting the signaling molecules involved in cell growth, survival, metastasis, and ...
Bi, Xiu-Li, Yang, Wancai
openaire   +2 more sources

Myopathy Associated With Dermatan Sulfate-Deficient Decorin and Myostatin in Musculocontractural Ehlers-Danlos Syndrome: A Mouse Model Investigation

Frontiers in Cell and Developmental Biology, 2021
Carbohydrate sulfotransferase 14 (CHST14) encodes dermatan 4-O-sulfotransferase 1, a critical enzyme for dermatan sulfate (DS) biosynthesis. Musculocontractural Ehlers-Danlos syndrome (mcEDS) is associated with biallelic pathogenic variants of CHST14 and
Yuko Nitahara-Kasahara, Yuko Nitahara-Kasahara, Guillermo Posadas-Herrera, Shuji Mizumoto, Aki Nakamura-Takahashi, Yukiko U. Inoue, Takayoshi Inoue, Yoshihiro Nomura, Shin’ichi Takeda, Shuhei Yamada, Tomoki Kosho, Tomoki Kosho, Tomoki Kosho, Tomoki Kosho, Takashi Okada   +14 more
doaj   +1 more source

Lytic and mechanical stability of clots composed of fibrin and blood vessel wall components. [PDF]

, 2013
Background Proteases expressed in atherosclerotic plaque lesions generate collagen fragments, release glycosaminoglycans (chondroitin sulfate [CS] and dermatan sulfate [DS]) and expose extracellular matrix (ECM) proteins (e.g.
Bóta, Attila, Kolev, K., Komorowicz, E., Longstaff, C., Machovich, R., Rottenberger, Z., Szabó, László, Varga, Zoltán   +7 more
core   +1 more source

Decorin treatment of spinal cord injury

Neural Regeneration Research, 2014
The scarring response after a penetrant central nervous system injury results from the interaction between invading leptominingeal/pericyte-derived fibroblasts and endogenous reactive astrocytes about the wound margin. Extracellular matrix and scar-derived axon growth inhibitory molecules fill the lesion site providing both a physical and chemical ...
Esmaeili, Maryam, Berry, Martin, Logan, Ann, Ahmed, Zubair   +3 more
openaire   +2 more sources

Efficacy of an Oncolytic Adenovirus Driven by a Chimeric Promoter and Armed with Decorin Against Renal Cell Carcinoma

Human Gene Therapy, 2020
Virus-targeted therapy for tumors can effectively prolong the survival rate of patients and has become a new trend for cancer biotherapy. Oncolytic adenovirus (OAd) can specifically replicate in tumor cells, allowing the therapeutic genes carried to be ...
Wen Zhang, Chen Zhang, Weiping Tian, Jing Qin, J. Chen, Qi Zhang, Lin Fang, Junnian Zheng   +7 more
semanticscholar   +1 more source

Decorin impeded the advancement of thyroid papillary carcinoma by thwarting the EGFR/ FER/ SHP2 signaling-induced sustenance of early endosomes

Heliyon
Objective: This study explores the inhibition of papillary thyroid carcinoma proliferation by Decorin via the EGFR/SHP2/FER pathway. Method: ology: Thirty-two pairs of papillary thyroid carcinoma tissues and adjacent normal tissues were collected for ...
Yaping Liu, Yunchao Xin, Tianyun Lv, Zhicheng Chang, Gang Xue, Xiaoling Shang   +5 more
doaj   +1 more source

Decorin knockdown affects the gene expression profile of adhesion, growth and extracellular matrix metabolism in C-28/I2 chondrocytes.

PLoS ONE, 2020
Decorin is a member of small leucine-rich proteoglycan family, which is involved in multiple biological functions mainly as a structural and signaling molecule, and disturbances in its own metabolism plays a crucial role in the pathogenesis of ...
Mengying Wang, Zhengzheng Li, Meng Zhang, Hui Wang, Ying Zhang, Yiping Feng, Yinan Liu, Jinghong Chen   +7 more
doaj   +1 more source

Decorin Concentrations in Aqueous Humor of Patients with Diabetic Retinopathy

Life, 2021
Diabetic retinopathy (DR) is a microvascular complication of diabetes in the retina. Chronic hyperglycemia damages retinal microvasculature embedded into the extracellular matrix (ECM), causing fluid leakage and ischemic retinal neovascularization ...
Shermaine W. Y. Low, Tanuja Vaidya, Santosh G. K. Gadde, Thirumalesh B. Mochi, Devesh Kumar, Iris S. Kassem, Deborah M. Costakos, Baseer Ahmad, Swaminathan Sethu, Arkasubhra Ghosh, Shyam S. Chaurasia   +10 more
doaj   +1 more source

Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology. [PDF]

, 2017
Inflammation and autophagy have emerged as prominent issues in the context of proteoglycan signaling. In particular, two small, leucine-rich proteoglycans, biglycan and decorin, play pivotal roles in the regulation of these vital cellular pathways and ...
Cohen IR, Douglass S, Kalas W, Mathiak M, Onita T, Zhu YH   +5 more
core   +2 more sources