Results 41 to 50 of about 14,894 (236)

In-vitro Apoptotic Effects of Deferoxamine on the Glioblastoma Cell Line

Iranian South Medical Journal, 2019
Background: Research suggests the inhibitory effects of deferoxamine as an iron chelator on erythroleukemia cells. The present study was conducted to investigate the effects of deferoxamine on B92 cells as a model of glial cells carcinoma.
Mahtab Pourkamalzadeh, Seyid Mesam Abtahi froushani   +1 more
doaj  

EBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes

Advanced Science, EarlyView.
EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen, Can Chen, Yichen Wu, Yinxue Xia, Ruijie Luo, Jiangcheng Shu, Long Chen, Zhaohui Wang, Cheng Wang, Kai Huang   +9 more
wiley   +1 more source

Application of Deferoxamine in Tissue Regeneration Attributed to Promoted Angiogenesis

Molecules
Deferoxamine, an iron chelator used to treat diseases caused by excess iron, has had a Food and Drug Administration-approved status for many years. A large number of studies have confirmed that deferoxamine can reduce inflammatory response and promote ...
Haijun Shen, Yane Ma, Yi Qiao, Chun Zhang, Jialing Chen, Ran Zhang   +5 more
doaj   +1 more source

Revealing the Mechanism of Exciton Spontaneous Separation at Room Temperature for Efficient Photocatalytic Hydrogen Peroxide Synthesis

Advanced Science, EarlyView.
This study identifies that replacing electron‐donating units at different positions enhances the delocalization of the electron cloud in the electron donors, which in turn increases the delocalization of the overall material. The exciton activation energy is effectively reduced, promoting the spontaneous dissociation of excitons at room temperature and
Pan Jiang, Yuyan Huang, Xiangqiong Jiang, Huijie Yan, Shufang Liu, Zuoming Chen, Xin Wu, Xiantai Zhou, Yu‐Xin Ye, Gangfeng Ouyang   +9 more
wiley   +1 more source

Unlocking the potential of deferoxamine: a systematic review on its efficacy and safety in alleviating myocardial ischemia-reperfusion injury in adult patients following cardiopulmonary bypass compared to standard care

Therapeutic Advances in Cardiovascular Disease
Background: Reperfusion injury, characterized by oxidative stress and inflammation, poses a significant challenge in cardiac surgery with cardiopulmonary bypass (CPB).
Aashish Lamichhane, Sadish Sharma, Bishwas Bastola, Bikesh Chhusyabaga, Nabin Shrestha, Prajwal Poudel   +5 more
doaj   +1 more source

Designing Deferoxamine-Loaded Flaxseed Gum and Carrageenan-Based Controlled Release Biocomposite Hydrogel Films for Wound Healing

Gels, 2022
In this study, biocomposite hydrogel films made from flaxseed gum (FSG)/kappa carrageenan (CGN) were fabricated, using potassium chloride as a crosslinker and glycerol as a plasticizer.
Tayyaba Sadiq, Syed Haroon Khalid, Ikram Ullah Khan, Hira Mahmood, Sajid Asghar   +4 more
doaj   +1 more source

KRAS/ABHD17C/ALOX15B Axis Promotes Pancreatic Cancer Progression via Ferroptosis Evasion

Advanced Science, EarlyView.
Phosphorylation of ABHD17C induced by KRASmut/ERK signaling facilitates ALOX15B depalmitoylation and degradation via the CUL4/DDB1/DCAF10 complex, thereby enabling KRASmut‐PDAC cell to evade ferroptosis. Methyl protodioscin inhibits KRASmut‐PDAC progression by disrupting the ABHD17C/ALOX15B interaction and inducing ferroptosis, which represents a ...
Man Li, Xuexin Yu, Yuanji Liu, Shuqin Ouyang, Long Wu, Xiaohong Chen, Huiqi Yu, Haoming Chen, Senmao Lian, Ziwen Li, Liyun Gong, Libing Song, Jun Li   +12 more
wiley   +1 more source

Antibacterial and Angiogenic Poly(ionic liquid) Hydrogels

Gels, 2022
Wounds, particularly under low-hydration conditions, require more time to repair successfully. Therefore, there is an urgent need to develop wound dressings that can accelerate wound healing.
Chengju Sheng, Xuemei Tan, Qing Huang, Kewen Li, Chao Zhou, Mingming Guo   +5 more
doaj   +1 more source

Combined Therapy with Deferoxamine and Deferiprone

Annals of the New York Academy of Sciences, 2005
Abstract: Therapy with either deferiprone (DFP) or deferoxamine (DFO) is inadequate in achieving negative iron balance in many patients with thalassemia. There are mounting theoretical, experimental, and clinical evidences of increased efficacy when therapy includes both chelating agents.
openaire   +4 more sources

Metal‐Ligand Complexes as Multifunctional Platforms for Photo‐Activated Cancer Therapy

Advanced Science, EarlyView.
Metal‐ligand complexes serve as multifunctional platforms for photo‐activated cancer therapy, facilitating photothermal and photodynamic effects through light absorption and reactive oxygen species generation. This review categorizes these complexes by ligand and metal types, examines their roles in combined therapeutic approaches, and explores ...
Jeonga Kim, Saehan Choi, Yoonsung Nam
wiley   +1 more source