Results 41 to 50 of about 32,113 (291)

Iron Effects on Clostridioides difficile Toxin Production and Antimicrobial Susceptibilities

Antibiotics, 2022
Despite the benefits of red blood cell (RBC) transfusion therapy, it can render patients vulnerable to iron overload. The excess iron deposits in various body tissues cause severe complications and organ damage such as cardiotoxicity and mold infections.
Jason Yamaki, Swati Chawla, Shirley Tong, Kate Alison Lozada, Sun Yang   +4 more
doaj   +1 more source

Combined chelation therapy in thalassemia major for the treatment of severe myocardial siderosis with left ventricular dysfunction

Journal of Cardiovascular Magnetic Resonance, 2008
Background In thalassemia major (TM), severe cardiac siderosis can be treated by continuous parenteral deferoxamine, but poor compliance, complications and deaths occur.
Pibiri Martina, Agus Annalisa, Westwood Mark A, Smith Gillian C, Dessi Carlo, Galanello Renzo, Tanner Mark A, Nair Sunil V, Walker J Malcolm, Pennell Dudley J   +9 more
doaj   +1 more source

Exosomes Derived from Human Bone Marrow Mesenchymal Stem Cells Stimulated by Deferoxamine Accelerate Cutaneous Wound Healing by Promoting Angiogenesis

BioMed Research International, 2019
The exosomes are derived from mesenchymal stem cells (MSCs) and may be potentially used as an alternative for cell therapy, for treating diabetic wounds, and aid in angiogenesis.
Jia-ning Ding, Xin Wang, Bi Chen, Jieyuan Zhang, Jianguang Xu   +4 more
semanticscholar   +1 more source

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. [PDF]

, 2017
Acquired drug resistance prevents cancer therapies from achieving stable and complete responses. Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer 'persister' cells.
Berens, Michael E, Bole, Dhruv, Dhruv, Harshil D, Eaton, John K, Galeas, Jacqueline, Hangauer, Matthew J, Matov, Alexandre, McCormick, Frank, McManus, Michael T, Ryan, Matthew J, Schreiber, Stuart L, Viswanathan, Vasanthi S   +11 more
core   +1 more source

Designing Deferoxamine-Loaded Flaxseed Gum and Carrageenan-Based Controlled Release Biocomposite Hydrogel Films for Wound Healing

Gels, 2022
In this study, biocomposite hydrogel films made from flaxseed gum (FSG)/kappa carrageenan (CGN) were fabricated, using potassium chloride as a crosslinker and glycerol as a plasticizer.
Tayyaba Sadiq, Syed Haroon Khalid, Ikram Ullah Khan, Hira Mahmood, Sajid Asghar   +4 more
doaj   +1 more source

Cardiovascular and hepatic toxicity of cocaine: potential beneficial effects of modulators of oxidative stress [PDF]

, 2015
Oxidative stress (OS) is thought to play an important role in the pharmacological and toxic effects of various drugs of abuse. Herein we review the literature on the mechanisms responsible for the cardiovascular and hepatic toxicity of cocaine with ...
Antonilli, Letizia, Badiani, Aldo, Grassi, Maria Caterina, Graziani, Manuela, Saso, Luciano, Togna, Anna Rita   +5 more
core   +4 more sources

N-Acetylcysteine Nanocarriers Protect against Oxidative Stress in a Cellular Model of Parkinson’s Disease

Antioxidants, 2020
Oxidative stress is a key mediator in the development and progression of Parkinson’s disease (PD). The antioxidant N-acetylcysteine (NAC) has generated interest as a disease-modifying therapy for PD but is limited due to poor bioavailability, a short ...
Leah Mursaleen, Brendon Noble, Stefanie Ho Yi Chan, Satyanarayana Somavarapu, Mohammed Gulrez Zariwala   +4 more
doaj   +1 more source

Evidence Favoring a Positive Feedback Loop for Physiologic Auto Upregulation of hnRNP-E1 during Prolonged Folate Deficiency in Human Placental Cells [PDF]

, 2017
Background: Previously, we determined that heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) functions as an intracellular physiologic sensor of folate deficiency.
Antony, Aśok C., Hansen, Deborah K., Jayaram, Hiremagalur N., Khan, Rehana A., Kusumanchi, Praveen, Stabler, Sally P., Tang, Ying-Sheng, Xiao, Suhong   +7 more
core   +1 more source

Deferoxamine retinopathy: spectral domain-optical coherence tomography findings [PDF]

, 2014
BACKGROUND: To describe the spectral domain optical coherence tomography (SD-OCT) findings of a patient who developed pigmentary retinopathy following high-dose deferoxamine administration.
Chao-Ping Yang, Cheng-Hsiu Wu, Chi-Chun Lai, Wei-Chi Wu, Yi-Hsing Chen   +4 more
core   +4 more sources

How to Improve the Antioxidant Defense in Asphyxiated Newborns—Lessons from Animal Models

Antioxidants, 2020
Oxygen free radicals have been implicated in brain damage after neonatal asphyxia. In the early phase of asphyxia/reoxygenation, changes in antioxidant enzyme activity play a pivotal role in switching on and off the cascade of events that can kill the ...
Hanna Kletkiewicz, Maciej Klimiuk, Alina Woźniak, Celestyna Mila-Kierzenkowska, Karol Dokladny, Justyna Rogalska   +5 more
doaj   +1 more source