Results 91 to 100 of about 97,922 (342)

Genetic detection of Sonic hedgehog (Shh) expression and cellular response in the progression of acute through chronic demyelination and remyelination

Neurobiology of Disease, 2018
Multiple sclerosis is a demyelinating disease in which neurological deficits result from damage to myelin, axons, and neuron cell bodies. Prolonged or repeated episodes of demyelination impair remyelination. We hypothesized that augmenting Sonic hedgehog
Maria A. Sanchez, Genevieve M. Sullivan, Regina C. Armstrong   +2 more
doaj   +1 more source

Volumetric MRI Comparing Longitudinal Change in MOGAD to NMOSD, MS and Healthy Controls, and Disability Associations

Annals of Neurology, EarlyView.
Objectives To examine volumetric magnetic resonance imaging (vMRI) in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), compared to multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and healthy controls (HC). Methods Standardized vMRI in MOGAD were compared to age, sex, and disease duration matched MS (5:1),
Amy Kunchok, Moein Amin, Tatchaporn Ongphichetmetha, Mengke Du, Robert Bermel, Tucker Harvey, Justin R. Abbatemarco, Stephen E. Jones, Jeffrey A. Cohen, Daniel Ontaneda, Kunio Nakamura   +10 more
wiley   +1 more source

Is psychosis, at least in part, an immune-related dysmyelination disease?

Dialogues in Clinical Neuroscience & Mental Health, 2019
Epidemiological studies have borne out the association between psychotic disorders and autoimmune disease, while the immunogenetic contribution in psychosis is largely dominated by the major histocompatibility complex genetic diversity. On the other hand,
Orestis Giotakos
doaj   +1 more source

Experimental Demyelination and Axonal Loss Are Reduced in MicroRNA-146a Deficient Mice

Frontiers in Immunology, 2018
Background The cuprizone (CPZ) model of multiple sclerosis (MS) was used to identify microRNAs (miRNAs) related to in vivo de- and remyelination. We further investigated the role of miR-146a in miR-146a-deficient (KO) mice: this miRNA is differentially ...
N. Martin, V. Molnar, G. Szilagyi, M. Elkjaer, A. Nawrocki, Justyna Okarmus, A. Wlodarczyk, Eva K. Thygesen, M. Palkovits, F. Gallyas, M. Larsen, H. Lassmann, E. Benedikz, T. Owens, Å. Svenningsen, Z. Illés   +15 more
semanticscholar   +1 more source

Frequency of Microvascular Pathology and Hippocampal Atrophy on Magnetic Resonance Imaging in a Community Study of Alzheimer's Disease with Blood‐Based Biomarkers

Annals of Neurology, EarlyView.
Objective Blood‐based biomarkers for Alzheimer's disease (AD), representing antemortem indicators of AD pathophysiology, have greatly improved the accuracy of diagnosis. However, these biomarkers may not capture a frequent coincident pathology, such as cerebrovascular disease.
Tamil Iniyan Gunasekaran, Danurys Sanchez, Dolly Reyes‐Dumeyer, Rabel Ventura, Clarissa Morales, Mohamad Alshikho, Annie J. Lee, Rafael A. Lantigua, Yian Gu, Lawrence S. Honig, Badri N. Vardarajan, Adam M. Brickman, Richard Mayeux   +12 more
wiley   +1 more source

Anaesthetic management in a patient with multiple sclerosis

Indian Journal of Anaesthesia, 2011
Multiple sclerosis (MS) is a rare autoimmune demyelinating disorder of the central nervous system clinically manifesting as periodic attacks of varied neurologic symptoms, eventually progressing to fixed neurologic deficits and disability.
Lata M Kulkarni, C S Sanikop, H L Shilpa, Anupama Vinayan   +3 more
doaj   +1 more source

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

Nature Communications, 2015
Autoimmunity and macrophage recruitment into the central nervous system (CNS) are critical determinants of neuroinflammatory diseases. However, the mechanisms that drive immunological responses targeted to the CNS remain largely unknown.
J. Ryu, Mark A. Petersen, Sara G. Murray, K. M. Baeten, A. Meyer‐Franke, Justin P. Chan, Eirini Vagena, C. Bedard, Michael R. Machado, Pamela E. Rios Coronado, T. Prod’homme, I. Charo, H. Lassmann, J. Degen, S. Zamvil, K. Akassoglou   +15 more
semanticscholar   +1 more source

Peptide/Antibody–Drug Conjugates for Therapeutic Applications in Inflammatory Disease

Advanced NanoBiomed Research, EarlyView.
Peptide/antibody–drug conjugates (PADCs) combine ligand specificity and cleavable linkers to deliver drugs precisely to disease sites with minimal toxicity. While current approvals focus on oncology, this review examines their untapped potential in inflammatory diseases, detailing mechanisms of targeted delivery and highlighting advances that position ...
Yeongji Jang, Jiwoong Choi, Youngri Ryu, Hyun Kyu Song, Man Kyu Shim, Yoosoo Yang   +5 more
wiley   +1 more source

Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis

BMEMat, EarlyView.
This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang, Yuchen Li, Yunfan Zhang, Chenshuang Li, Yifan Lin, Si Chen, Bing Han   +6 more
wiley   +1 more source

Cuprizone Demyelination of the Corpus Callosum in Mice Correlates with Altered Social Interaction and Impaired Bilateral Sensorimotor Coordination

ASN Neuro, 2009
For studies of remyelination in demyelinating diseases, the cuprizone model of CC (corpus callosum) demyelination has experimental advantages that include overall size, proximity to neural stem cells of the subventricular zone, and correlation with a ...
Norah Hibbits, Ravinder Pannu, T John Wu, Regina C Armstrong   +3 more
doaj   +1 more source