Results 101 to 110 of about 104,217 (332)

Ultrasound Controlled‐Release Hydrogel Promotes Diabetic Wound Healing via Neuroimmune Modulation and Synergistic ROS Scavenging

Advanced Science, EarlyView.
This study presents an ultrasound‐responsive hydrogel (MCF@CA) that co‐delivers a neuropeptide (CGRP) and a ROS‐scavenging manganese porphyrin to diabetic wounds. The system restores neuro‐immune communication, reprograms macrophages toward an anti‐inflammatory phenotype, and clears excess ROS, thereby accelerating wound closure and promoting mature ...
Mofan Li, Mengxin Wang, Haonan Wang, Yang Sun, Yongyue Zhang, Shuyu Xu, Tianjiao Zhang, Shiti Shama, Xiaolong Liang, Shumin Wang   +9 more
wiley   +1 more source

Depletion of Microglia Increases Cortical Oligodendrocyte Density During Remyelination. [PDF]

Glia
Cuprizone demyelination induces transient reactive states in deep cortical microglia (MG) through early recovery. Depleting MG in recovery increases the number of deep cortical mature/pre‐myelinating oligodendrocytes. Deep cortical reactive MG reduce oligodendrocyte density after demyelination.
Loo HK, Gallegos J, Mialki C, Perrin GE, Malloy T, Orthmann-Murphy JL.   +5 more
europepmc   +2 more sources

Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis

Acta Neuropathologica, 2017
Cortical demyelination is a widely recognized hallmark of multiple sclerosis (MS) and correlate of disease progression and cognitive decline. The pathomechanisms initiating and driving gray matter damage are only incompletely understood.
Nielsen Lagumersindez-Denis, Claudia Wrzos, M. Mack, A. Winkler, F. van der Meer, M. Reinert, Heiko Hollasch, A. Flach, H. Brühl, E. Cullen, C. Schlumbohm, E. Fuchs, C. Linington, A. Barrantes-Freer, I. Metz, C. Wegner, D. Liebetanz, M. Prinz, W. Brück, C. Stadelmann, S. Nessler   +20 more
semanticscholar   +1 more source

Immunoaffinity‐Mimetic Assembly of Peptide‐Aptamer Conjugates and Stem Cell‐Derived Exosomes into Hierarchical Microgels for Spinal Cord Injury Repair

Advanced Science, EarlyView.
Inspired by antibody‐antigen binding, this study develops an unprecedented immunoaffinity‐mimetic assembly strategy, with Peptide‐AptCD63 conjugates acting as antibody surrogates binding CD63 epitopes on mesenchymal stem cell‐derived exosomes. This creates a hierarchical microstructure intended to synergistically integrate antioxidative and anti ...
Dantong Zheng, Yuxin Bai, Zhibo Liu, Zinan Zhao, Yiming Kong, Yao Xu, Qi Jia, Rongrong Zhu, Yong Hu   +8 more
wiley   +1 more source

Demyelination

, 2016
Abstract This chapter describes various clues to the diagnosis of multiple sclerosis (MS) based on the history, physical examination and investigation. Red flags that should alert the clinician to an alternative diagnosis are listed. Disorders that may present like MS and lead to erroneous diagnosis are discussed.
Christopher H. Hawkes, Kapil D. Sethi, Thomas R. Swift   +2 more
openaire   +2 more sources

Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model

Acta Neuropathologica Communications, 2017
In neuroinflammatory disorders such as multiple sclerosis, the physiological function of the blood-brain barrier (BBB) is perturbed, particularly in demyelinating lesions and supposedly secondary to acute demyelinating pathology.
Stefan A Berghoff, Tim Düking, L. Spieth, J. Winchenbach, S. Stumpf, Nina Gerndt, Kathrin Kusch, T. Ruhwedel, W. Möbius, G. Saher   +9 more
semanticscholar   +1 more source

Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases

Advanced Science, EarlyView.
Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh, Amir Tahavvori, Cyrus E. Kuschner, Blanca B. Espin, Jacob Kazmi, Sofhia V. Ramos, Tai Yin, Kei Hayashida, Kanako Ito‐Hagiwara, Yusuke Endo, Keitaro Yoshioka, Jun Hagiwara, Avijot Sohi, Alisha Oropallo, Ghania Haddad, Timmy Li, Lance B. Becker, Junhwan Kim   +17 more
wiley   +1 more source

Tumefactive demyelination after covid-19 successfully treated with betainterferon 1A

, 2022
Victor Oliveira Araújo, Paulo Filho Soares Marcelino, Samuel Ramos Rabelo, Fábio Antônio Serra de Lima Júnior, Vitor Gil Gonçalves Teixeira, Roberto Rocha Eisele, Afonso Rocha Eisele, João Pedro Serenario Ferreira de Carvalho, Luciano Barroso de Albuquerque Filho, Sara Diógenes Peixoto de Medeiros, Leandro Freitas Oliveira, Júlio César Claudino dos Santos, Euldes Mendes Júnior   +12 more
openalex   +1 more source

Histological validation of fast macromolecular proton fraction mapping as a quantitative myelin imaging method in the cuprizone demyelination model

Scientific Reports, 2017
Cuprizone-induced demyelination in mice is a frequently used model in preclinical multiple sclerosis research. A recent quantitative clinically-targeted MRI method, fast macromolecular proton fraction (MPF) mapping demonstrated a promise as a myelin ...
M. Khodanovich, I. Sorokina, V. Glazacheva, A. Akulov, N. Nemirovich-Danchenko, A. Romashchenko, T. Tolstikova, L. Mustafina, V. Yarnykh   +8 more
semanticscholar   +1 more source

Insights into organelle forming RNAs: Diversity, functions and future perspectives

Animal Models and Experimental Medicine, EarlyView.
RNA molecules play crucial roles in the formation and maintenance of cellular structures and organelles. These ‘organelle formation RNAs’ include ribosomal RNAs, paraspeckle‐forming RNAs, nuclear speckle‐forming RNAs, nucleolus‐forming RNAs, and cytoskeleton‐forming RNA.
Meng Gong, Xiangting Wang, Xiaolin Liang
wiley   +1 more source