Results 11 to 20 of about 70,292 (240)

Butyrate suppresses demyelination and enhances remyelination

Journal of Neuroinflammation, 2019
Background The association of gut microbiota and diseases of the central nervous system (CNS), including multiple sclerosis (MS), has attracted much attention.
Tong Chen, Daisuke Noto, Yasunobu Hoshino, Miho Mizuno, Sachiko Miyake   +4 more
doaj   +1 more source

Dynamic response of microglia/macrophage polarization following demyelination in mice

Journal of Neuroinflammation, 2019
Background The glial response in multiple sclerosis (MS), especially for recruitment and differentiation of oligodendrocyte progenitor cells (OPCs), predicts the success of remyelination of MS plaques and return of function.
Tianci Chu, Yi Ping Zhang, Zhisen Tian, Chuyuan Ye, Mingming Zhu, Lisa B. E. Shields, Maiying Kong, Gregory N. Barnes, Christopher B. Shields, Jun Cai   +9 more
doaj   +1 more source

Key role of the gut–microbiota–brain axis via the subdiaphragmatic vagus nerve in demyelination of the cuprizone-treated mouse brain

Neurobiology of Disease, 2023
Multiple sclerosis (MS) is the most common demyelinating disease that attacks the central nervous system. Dietary intake of cuprizone (CPZ) produces demyelination resembling that of patients with MS.
Xingming Wang, Akifumi Eguchi, Yong Yang, Lijia Chang, Xiayun Wan, Jiajing Shan, Youge Qu, Li Ma, Chisato Mori, Jianjun Yang, Kenji Hashimoto   +10 more
doaj   +1 more source

Deficiency of microglial Hv1 channel is associated with activation of autophagic pathway and ROS production in LPC-induced demyelination mouse model

Journal of Neuroinflammation, 2020
Background Multiple sclerosis (MS) is an immune-mediated demyelinated disease of the central nervous system. Activation of microglia is involved in the pathogenesis of myelin loss.
Man Chen, Lin-Lin Yang, Zi-Wei Hu, Chuan Qin, Luo-Qi Zhou, Ya-ling Duan, Dale B. Bosco, Long-Jun Wu, Ke-Bin Zhan, Sha-Bei Xu, Dai-Shi Tian   +10 more
doaj   +1 more source

Immunological Demyelination Triggers Macrophage/Microglial Cells Activation without Inducing Astrogliosis

Clinical and Developmental Immunology, 2013
The glial scar formed by reactive astrocytes and axon growth inhibitors associated with myelin play important roles in the failure of axonal regeneration following central nervous system (CNS) injury.
Frank Cloutier, Ilse Sears-Kraxberger, Krista Keachie, Hans S. Keirstead   +3 more
doaj   +1 more source

Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice

Nature Communications, 2022
Ischemic stroke can cause secondary demyelination. Whether phagocytic astrocytes can contribute to such demyelination is unclear. Here, the authors show that lipocalin-2 (LCN-2) expression increased in astrocytes upon injury.
Ting Wan, Wusheng Zhu, Ying Zhao, Xiaohao Zhang, Ruidong Ye, Meng Zuo, Pengfei Xu, Zhenqian Huang, Chunni Zhang, Yi Xie, Xinfeng Liu   +10 more
doaj   +1 more source

Astrogliosis During Acute and Chronic Cuprizone Demyelination and Implications for Remyelination

ASN Neuro, 2012
In multiple sclerosis, microglia/macrophage activation and astrocyte reactivity are important components of the lesion environment that can impact remyelination.
Norah Hibbits, Jun Yoshino, Tuan Q. Le, Regina C. Armstrong   +3 more
doaj   +1 more source

Exogenous Antioxidants in Remyelination and Skeletal Muscle Recovery

Biomedicines, 2022
Inflammatory, oxidative, and autoimmune responses cause severe damage to the nervous system inducing loss of myelin layers or demyelination. Even though demyelination is not considered a direct cause of skeletal muscle disease there is extensive damage ...
Ricardo Julián Cabezas Perez, Marco Fidel Ávila Rodríguez, Doris Haydee Rosero Salazar   +2 more
doaj   +1 more source

Demyelinating diseases [PDF]

Journal of Clinical Pathology, 2006
A diagnosis of demyelination carries important therapeutic and prognostic implications. In most cases the diagnosis is made clinically, and involvement of the histopathologist is largely confined to postmortem confirmation and clinicopathological correlation.
openaire   +3 more sources

CHARACTERIZATION OF SIGNAL CONDUCTION ALONG DEMYELINATED AXONS BY ACTION-POTENTIAL-ENCODED SECOND HARMONIC GENERATION [PDF]

Journal of Innovative Optical Health Sciences, 2014
Action-potential-encoded optical second harmonic generation (SHG) has been recently proposed for use in detecting the axonal damage in patients with demyelinating diseases.
ZHI-HUI LUO, JIANG-XU CHEN, YI-MEI HUANG, HONG-QIN YANG, JU-QIANG LIN, HUI LI, SHU-SEN XIE   +6 more
doaj   +1 more source