Results 11 to 20 of about 104,217 (332)

Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice

Nature Communications, 2022
Ischemic stroke can cause secondary demyelination. Whether phagocytic astrocytes can contribute to such demyelination is unclear. Here, the authors show that lipocalin-2 (LCN-2) expression increased in astrocytes upon injury.
Ting Wan, Wusheng Zhu, Ying Zhao, Xiaohao Zhang, Ruidong Ye, Meng Zuo, Pengfei Xu, Zhenqian Huang, Chunni Zhang, Yi Xie, Xinfeng Liu   +10 more
doaj   +2 more sources

Butyrate suppresses demyelination and enhances remyelination

Journal of Neuroinflammation, 2019
Background The association of gut microbiota and diseases of the central nervous system (CNS), including multiple sclerosis (MS), has attracted much attention.
Tong Chen, Daisuke Noto, Yasunobu Hoshino, Miho Mizuno, Sachiko Miyake   +4 more
doaj   +2 more sources

Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4/MyD88/NF-κB pathway in LPC-induced demyelination

Journal of Neuroinflammation, 2023
Demyelination occurs in multiple central nervous system (CNS) disorders and is tightly associated with neuroinflammation. Pyroptosis is a form of pro-inflammatory and lytic cell death which has been observed in CNS diseases recently.
Yao Wang, Dilinuer Sadike, Bo Huang, Ping Li, Qiao Wu, Na Jiang, Yongkang Fang, Guini Song, Li Xu, Wei Wang, Minjie Xie   +10 more
doaj   +2 more sources

Deficiency of microglial Hv1 channel is associated with activation of autophagic pathway and ROS production in LPC-induced demyelination mouse model

Journal of Neuroinflammation, 2020
Background Multiple sclerosis (MS) is an immune-mediated demyelinated disease of the central nervous system. Activation of microglia is involved in the pathogenesis of myelin loss.
Man Chen, Lin-Lin Yang, Zi-Wei Hu, Chuan Qin, Luo-Qi Zhou, Ya-ling Duan, Dale B. Bosco, Long-Jun Wu, Ke-Bin Zhan, Sha-Bei Xu, Dai-Shi Tian   +10 more
doaj   +2 more sources

Dynamic response of microglia/macrophage polarization following demyelination in mice

Journal of Neuroinflammation, 2019
Background The glial response in multiple sclerosis (MS), especially for recruitment and differentiation of oligodendrocyte progenitor cells (OPCs), predicts the success of remyelination of MS plaques and return of function.
Tianci Chu, Yi Ping Zhang, Zhisen Tian, Chuyuan Ye, Mingming Zhu, Lisa B. E. Shields, Maiying Kong, Gregory N. Barnes, Christopher B. Shields, Jun Cai   +9 more
doaj   +2 more sources

New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination [PDF]

Nature Neuroscience, 2020
Oligodendrocytes that survive demyelination can remyelinate, including in multiple sclerosis (MS), but how they do so is unclear. In this study, using zebrafish, we found that surviving oligodendrocytes make few new sheaths and frequently mistarget new ...
Sarah A. Neely, J Williamson, Anna Klingseisen, Lida Zoupi, Jason J. Early, Anna Williams, David A. Lyons   +6 more
openalex   +2 more sources

Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination

Molecular Neurodegeneration, 2022
Background The dietary consumption of cuprizone – a copper chelator – has long been known to induce demyelination of specific brain structures and is widely used as model of multiple sclerosis.
M. Zirngibl, P. Assinck, Anastasia Sizov, A. Caprariello, Jason R. Plemel   +4 more
semanticscholar   +1 more source

Osmotic Demyelination Syndrome in Patients Hospitalized with Hyponatremia.

NEJM Evidence, 2023
Osmotic Demyelination Syndrome and HyponatremiaThe authors estimated the frequency of occurrence of osmotic demyelination syndrome (ODS) after correction of hyponatremia (i.e., serum sodium
T. MacMillan, Saeha Shin, J. Topf, J. Kwan, A. Weinerman, T. Tang, A. Raissi, R. Koppula, F. Razak, A. Verma, M. Fralick   +10 more
semanticscholar   +1 more source

Liraglutide attenuate central nervous inflammation and demyelination through AMPK and pyroptosis‐related NLRP3 pathway

CNS Neuroscience & Therapeutics, 2022
Multiple sclerosis (MS) still maintains increasing prevalence and poor prognosis, while glucagon‐like peptide‐1 receptor (GLP‐1R) agonists show excellent neuroprotective capacities recently. Thus, we aim to evaluate whether the GLP‐1R agonist liraglutide
Shuang Song, Ruoyi Guo, Arshad Mehmood, Lujun Zhang, B. Yin, Congcong Yuan, Huining Zhang, Li Guo, Bin Li   +8 more
semanticscholar   +1 more source

Activated microglia drive demyelination via CSF1R signaling

Glia, 2021
Microgliosis is a prominent pathological feature in many neurological diseases including multiple sclerosis (MS), a progressive auto‐immune demyelinating disorder.
Dave E Marzan, Valérie Brügger-Verdon, B. West, SA Liddelow, J. Samanta, J. Salzer   +5 more
semanticscholar   +1 more source