Results 11 to 20 of about 97,922 (342)

Association of CNS demyelination and COVID-19 infection: an updated systematic review

Journal of Neurology, 2021
Since the declaration of COVID-19 pandemic, several case reports of demyelination of both peripheral and central nervous systems have been published. The association between CNS demyelination and viral infection has long been documented, and this link ...
I. Ismail, S. Salama
semanticscholar   +1 more source

Suppression of IL-12p70 formation by IL-2 or following macrophage depletion causes T-cell autoreactivity leading to CNS demyelination in HSV-1-infected mice. [PDF]

PLoS Pathogens, 2017
We have established two mouse models of central nervous system (CNS) demyelination that differ from most other available models of multiple sclerosis (MS) in that they represent a mixture of viral and immune triggers. In the first model, ocular infection
Dhong Hyun Lee, Mandana Zandian, Jane Kuo, Kevin R Mott, Shuang Chen, Moshe Arditi, Homayon Ghiasi   +6 more
doaj   +1 more source

Virus Demyelination [PDF]

Journal of Neurovirology, 2003
A number of viruses can initiate central nervous system (CNS) diseases that include demyelination as a major feature of neuropathology. In humans, the most prominent demyelinating diseases are progressive multifocal leukoencephalopathy, caused by JC papovirus destruction of oligodendrocytes, and subacute sclerosing panencephalitis, an invariably fatal ...
Fazakerley, JK, Walker, R
openaire   +4 more sources

Demyelination of the Optic Nerve: An Underlying Factor in Glaucoma?

Frontiers in Aging Neuroscience, 2021
Neurodegenerative disorders are characterized by typical neuronal degeneration and axonal loss in the central nervous system (CNS). Demyelination occurs when myelin or oligodendrocytes experience damage.
Jingfei Xue, Yingting Zhu, Zhe Liu, Jicheng Lin, Yangjiani Li, Yiqing Li, Yehong Zhuo   +6 more
doaj   +1 more source

Effects of Bone Marrow Mesenchymal Stem Cells on Myelin Repair and Emotional Changes of a Cuprizone-Induced Demyelination Model

Journal of Integrative Neuroscience, 2023
Background: Multiple sclerosis (MS) is an autoimmune disease for which bone marrow mesenchymal stem cells (BM-MSCs) have become one of the most promising tools for treatment.
Chu Lei, Haowei Chen, Kangning Chen
doaj   +1 more source

(R)-ketamine ameliorates demyelination and facilitates remyelination in cuprizone-treated mice: A role of gut–microbiota–brain axis

Neurobiology of Disease, 2022
Multiple sclerosis (MS) is the most common demyelinating disease that attacks the central nervous system. We recently reported that the new antidepressant (R)-ketamine could ameliorate the disease progression in experimental autoimmune encephalomyelitis ...
Xingming Wang, Lijia Chang, Xiayun Wan, Yunfei Tan, Youge Qu, Jiajing Shan, Yong Yang, Li Ma, Kenji Hashimoto   +8 more
doaj   +1 more source

Type 2 Innate Lymphoid Cells Induce CNS Demyelination in an HSV-IL-2 Mouse Model of Multiple Sclerosis

iScience, 2020
Summary: We previously reported that infection of different mouse strains with a recombinant HSV-1 expressing IL-2 (HSV-IL-2) caused CNS demyelination.
Satoshi Hirose, Pedram Shafiei Jahani, Shaohui Wang, Ujjaldeep Jaggi, Kati Tormanen, Jack Yu, Mihoko Kato, Omid Akbari, Homayon Ghiasi   +8 more
doaj   +1 more source

Valproic acid suppresses cuprizone-induced hippocampal demyelination and anxiety-like behavior by promoting cholesterol biosynthesis

Neurobiology of Disease, 2021
Myelin consists of several layers of tightly compacted membranes that form an insulating sheath around axons. These membranes are highly enriched in cholesterol, which is essential for the myelination process.
Xinjian Zhu, Yuanyuan Yao, Yang Hu, Jiurong Yang, Canyu Zhang, Yuqi He, Aifeng Zhang, Xiufang Liu, Chenchen Zhang, Guangming Gan   +9 more
doaj   +1 more source

Ferroptosis Mediates Cuprizone-Induced Loss of Oligodendrocytes and Demyelination

Journal of Neuroscience, 2020
Multiple sclerosis (MS) is a chronic demyelinating disease of the CNS. Cuprizone (CZ), a copper chelator, is widely used to study demyelination and remyelination in the CNS, in the context of MS.
Priya Jhelum, Eva Santos-Nogueira, Wulin Teo, A. Haumont, Isadora Lenoël, P. Stys, S. David   +6 more
semanticscholar   +1 more source

Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion

Science Advances, 2020
Microglia respond to white matter injury with different populations that prevent macrophage dispersion into spared tissue. Microglia and infiltrating macrophages are thought to orchestrate the central nervous system (CNS) response to injury; however, the
Jason R. Plemel, Jason R. Plemel, J. A. Stratton, Nathan J. Michaels, Khalil S. Rawji, Eric L Zhang, S. Sinha, Charbel S. Baaklini, Yifei Dong, Madelene Ho, Kevin Thorburn, Timothy N. Friedman, Sana Jawad, Cláudia Silva, A. Caprariello, Vahid Hoghooghi, Julie Yue, A. Jaffer, Kelly V. Lee, B. Kerr, R. Midha, P. Stys, J. Biernaskie, V. Yong   +23 more
semanticscholar   +1 more source