Results 21 to 30 of about 104,217 (332)

Association of CNS demyelination and COVID-19 infection: an updated systematic review

Journal of Neurology, 2021
Since the declaration of COVID-19 pandemic, several case reports of demyelination of both peripheral and central nervous systems have been published. The association between CNS demyelination and viral infection has long been documented, and this link ...
I. Ismail, S. Salama
semanticscholar   +1 more source

Valproic acid suppresses cuprizone-induced hippocampal demyelination and anxiety-like behavior by promoting cholesterol biosynthesis

Neurobiology of Disease, 2021
Myelin consists of several layers of tightly compacted membranes that form an insulating sheath around axons. These membranes are highly enriched in cholesterol, which is essential for the myelination process.
Xinjian Zhu, Yuanyuan Yao, Yang Hu, Jiurong Yang, Canyu Zhang, Yuqi He, Aifeng Zhang, Xiufang Liu, Chenchen Zhang, Guangming Gan   +9 more
doaj   +1 more source

Ferroptosis Mediates Cuprizone-Induced Loss of Oligodendrocytes and Demyelination

Journal of Neuroscience, 2020
Multiple sclerosis (MS) is a chronic demyelinating disease of the CNS. Cuprizone (CZ), a copper chelator, is widely used to study demyelination and remyelination in the CNS, in the context of MS.
Priya Jhelum, Eva Santos-Nogueira, Wulin Teo, A. Haumont, Isadora Lenoël, P. Stys, S. David   +6 more
semanticscholar   +1 more source

Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion

Science Advances, 2020
Microglia respond to white matter injury with different populations that prevent macrophage dispersion into spared tissue. Microglia and infiltrating macrophages are thought to orchestrate the central nervous system (CNS) response to injury; however, the
Jason R. Plemel, Jason R. Plemel, J. A. Stratton, Nathan J. Michaels, Khalil S. Rawji, Eric L Zhang, S. Sinha, Charbel S. Baaklini, Yifei Dong, Madelene F. S. Ho, Kevin Thorburn, Timothy N. Friedman, Sana Jawad, Cláudia Silva, A. Caprariello, Vahid Hoghooghi, Julie Yue, A. Jaffer, Kelly V. Lee, B. Kerr, R. Midha, P. Stys, J. Biernaskie, V. W. Yong   +23 more
semanticscholar   +1 more source

Key role of the gut–microbiota–brain axis via the subdiaphragmatic vagus nerve in demyelination of the cuprizone-treated mouse brain

Neurobiology of Disease, 2023
Multiple sclerosis (MS) is the most common demyelinating disease that attacks the central nervous system. Dietary intake of cuprizone (CPZ) produces demyelination resembling that of patients with MS.
Xingming Wang, Akifumi Eguchi, Yong Yang, Lijia Chang, Xiayun Wan, Jiajing Shan, Youge Qu, Li Ma, Chisato Mori, Jianjun Yang, Kenji Hashimoto   +10 more
doaj   +1 more source

Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination

Journal of Neurology Neurosurgery & Psychiatry, 2017
Objective We characterised the clinical course, treatment and outcomes in 59 patients with relapsing myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination.
S. Ramanathan, S. Mohammad, E. Tantsis, Tina Nguyen, V. Merheb, V. Fung, O. White, S. Broadley, J. Lechner-Scott, S. Vucic, A. Henderson, M. Barnett, S. Reddel, F. Brilot, R. Dale   +14 more
semanticscholar   +1 more source

Immunological Demyelination Triggers Macrophage/Microglial Cells Activation without Inducing Astrogliosis

Clinical and Developmental Immunology, 2013
The glial scar formed by reactive astrocytes and axon growth inhibitors associated with myelin play important roles in the failure of axonal regeneration following central nervous system (CNS) injury.
Frank Cloutier, Ilse Sears-Kraxberger, Krista Keachie, Hans S. Keirstead   +3 more
doaj   +1 more source

Astrogliosis During Acute and Chronic Cuprizone Demyelination and Implications for Remyelination

ASN Neuro, 2012
In multiple sclerosis, microglia/macrophage activation and astrocyte reactivity are important components of the lesion environment that can impact remyelination.
Norah Hibbits, Jun Yoshino, Tuan Q. Le, Regina C. Armstrong   +3 more
doaj   +1 more source

Exogenous Antioxidants in Remyelination and Skeletal Muscle Recovery

Biomedicines, 2022
Inflammatory, oxidative, and autoimmune responses cause severe damage to the nervous system inducing loss of myelin layers or demyelination. Even though demyelination is not considered a direct cause of skeletal muscle disease there is extensive damage ...
Ricardo Julián Cabezas Perez, Marco Fidel Ávila Rodríguez, Doris Haydee Rosero Salazar   +2 more
doaj   +1 more source

Demyelinating diseases [PDF]

Journal of Clinical Pathology, 2006
A diagnosis of demyelination carries important therapeutic and prognostic implications. In most cases the diagnosis is made clinically, and involvement of the histopathologist is largely confined to postmortem confirmation and clinicopathological correlation.
openaire   +3 more sources