Results 21 to 30 of about 97,922 (342)

New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination

Nature Neuroscience, 2020
Oligodendrocytes that survive demyelination can remyelinate, including in multiple sclerosis (MS), but how they do so is unclear. In this study, using zebrafish, we found that surviving oligodendrocytes make few new sheaths and frequently mistarget new ...
Sarah A. Neely, Jill M Williamson, Anna Klingseisen, Lida Zoupi, J. Early, Anna C. Williams, D. Lyons   +6 more
semanticscholar   +1 more source

Key role of the gut–microbiota–brain axis via the subdiaphragmatic vagus nerve in demyelination of the cuprizone-treated mouse brain

Neurobiology of Disease, 2023
Multiple sclerosis (MS) is the most common demyelinating disease that attacks the central nervous system. Dietary intake of cuprizone (CPZ) produces demyelination resembling that of patients with MS.
Xingming Wang, Akifumi Eguchi, Yong Yang, Lijia Chang, Xiayun Wan, Jiajing Shan, Youge Qu, Li Ma, Chisato Mori, Jianjun Yang, Kenji Hashimoto   +10 more
doaj   +1 more source

Enhanced axonal response of mitochondria to demyelination offers neuroprotection: implications for multiple sclerosis

Acta Neuropathologica, 2020
Axonal loss is the key pathological substrate of neurological disability in demyelinating disorders, including multiple sclerosis (MS). However, the consequences of demyelination on neuronal and axonal biology are poorly understood.
Simon Licht-Mayer, G. Campbell, Marco A Cañizares, A. Mehta, A. Gane, Katie McGill, Aniket Ghosh, Alexander Fullerton, Niels Menezes, J. Dean, Jordon Dunham, Sarah Al-Azki, G. Pryce, S. Zandee, Chao Zhao, M. Kipp, Kenneth J. Smith, D. Baker, D. Altmann, S. Anderton, Y. Kap, J. Laman, B. Hart, Moses Rodriguez, Ralf Watzlawick, J. Schwab, R. Carter, N. Morton, M. Zagnoni, R. Franklin, R. Mitchell, S. Fleetwood-Walker, D. Lyons, S. Chandran, H. Lassmann, B. Trapp, D. Mahad   +36 more
semanticscholar   +1 more source

Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination

Journal of Neurology Neurosurgery & Psychiatry, 2017
Objective We characterised the clinical course, treatment and outcomes in 59 patients with relapsing myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination.
S. Ramanathan, S. Mohammad, E. Tantsis, Tina Nguyen, V. Merheb, V. Fung, O. White, S. Broadley, J. Lechner-Scott, S. Vucic, A. Henderson, M. Barnett, S. Reddel, F. Brilot, R. Dale   +14 more
semanticscholar   +1 more source

Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination

Nature Communications, 2019
Oligodendrocyte precursor cells (OPCs) are abundant in the adult central nervous system, and have the capacity to regenerate oligodendrocytes and myelin. However, in inflammatory diseases such as multiple sclerosis (MS) remyelination is often incomplete.
L. Kirby, Jing Jin, J. Cardona, Matthew D. Smith, Kyle A. Martin, Jingya Wang, Hayley J Strasburger, Leyla R Herbst, M. Alexis, J. Karnell, Todd S. Davidson, Ranjan Dutta, J. Goverman, D. Bergles, P. Calabresi   +14 more
semanticscholar   +1 more source

Hymenoptera sting as atypical causative factor for Guillain Barré Syndrome and chronic inflammatory demyelinating polyneuropathy – A case report and insights on pathophysiology [PDF]

Romanian Journal of Neurology, 2023
Introduction. Neurological manifestations secondary to Hymenoptera stings are rare. However, the literature describes cases of severe central and peripheral nervous system damage.
Cristina Gatcan, Thomas Gabriel Schreiner, Violeta Sapira, Cristina Grosu, Bogdan Emilian Ignat   +4 more
doaj   +1 more source

Immunological Demyelination Triggers Macrophage/Microglial Cells Activation without Inducing Astrogliosis

Clinical and Developmental Immunology, 2013
The glial scar formed by reactive astrocytes and axon growth inhibitors associated with myelin play important roles in the failure of axonal regeneration following central nervous system (CNS) injury.
Frank Cloutier, Ilse Sears-Kraxberger, Krista Keachie, Hans S. Keirstead   +3 more
doaj   +1 more source

Exogenous Antioxidants in Remyelination and Skeletal Muscle Recovery

Biomedicines, 2022
Inflammatory, oxidative, and autoimmune responses cause severe damage to the nervous system inducing loss of myelin layers or demyelination. Even though demyelination is not considered a direct cause of skeletal muscle disease there is extensive damage ...
Ricardo Julián Cabezas Perez, Marco Fidel Ávila Rodríguez, Doris Haydee Rosero Salazar   +2 more
doaj   +1 more source

Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus infection

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Microglia are the resident phagocytic cells of the central nervous system (CNS). During demyelination, a condition in which myelin sheaths are damaged and removed from neurons due to inflammation, microglia can play both harmful and ...
A. Sariol, Samantha R. Mackin, Merri-Grace Allred, Chen Ma, Yu Zhou, Qinran Zhang, Xiufen Zou, J. Abrahante, D. Meyerholz, S. Perlman   +9 more
semanticscholar   +1 more source

Astrogliosis During Acute and Chronic Cuprizone Demyelination and Implications for Remyelination

ASN Neuro, 2012
In multiple sclerosis, microglia/macrophage activation and astrocyte reactivity are important components of the lesion environment that can impact remyelination.
Norah Hibbits, Jun Yoshino, Tuan Q. Le, Regina C. Armstrong   +3 more
doaj   +1 more source