Results 31 to 40 of about 37,089 (146)

The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain

Brain : a journal of neurology, 2016
Multiple sclerosis is characterized by widespread primary demyelination and progressive degeneration, driven by heterogeneous mechanisms. Haider et al.
L. Haider, Tobias Zrzavy, S. Hametner, R. Höftberger, F. Bagnato, G. Grabner, S. Trattnig, S. Pfeifenbring, W. Brück, H. Lassmann   +9 more
semanticscholar   +1 more source

Autotaxin and lysophosphatidic acid₁ receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidylcholine

Molecular Pain, 2010
Background Although neuropathic pain is frequently observed in demyelinating diseases such as Guillain-Barré syndrome and multiple sclerosis, the molecular basis for the relationship between demyelination and neuropathic pain behaviors is poorly ...
Aoki Junken, Niwa Masami, Ueda Mutsumi, yano Ryo, Matsushita Yosuke, Uchida Hitoshi, Nagai Jun, Chun Jerold, Ueda Hiroshi   +8 more
doaj   +1 more source

Relationship between cerebrospinal fluid protein level and electrophysiologic abnormalities in the acute inflammatory demyelinating polyradiculoneuropathy variant of Guillain-Barré syndrome

GMS German Medical Science, 2021
Objective: Guillain-Barré syndrome (GBS) is an autoimmune disease characterized by weakness in limbs or cranial nerve innervated muscles. Acute inflammatory demyelinating polyradiculoneuropathy (AIDP) is the most common variant.
Jawaid, Wajid, Sana, Rabia, Umer, Sumera Rafat, Nisa, Qamar, Butt, Mehwish, Shahbaz, Naila   +5 more
doaj   +1 more source

Treatment Approaches for MOG-Ab-Associated Demyelination in Children

Current Treatment Options in Neurology, 2019
Purpose of reviewThe purpose of this review is to summarize current understanding regarding the treatment of myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-associated demyelination in children.
Y. Hacohen, B. Banwell
semanticscholar   +1 more source

CNS Demyelination with TNF-α Blockers

Current Neurology and Neuroscience Reports, 2017
Tumor necrosis factor–α (TNF-α) blockers are a popular therapeutic choice in a number of inflammatory diseases. Thus far, five TNF- α blockers have been approved for clinical use (etanercept, infliximab, adalimumab, golimumab. and certolizumab).
E. Kemanetzoglou, E. Andreadou
semanticscholar   +1 more source

(R)-ketamine ameliorates demyelination and facilitates remyelination in cuprizone-treated mice: A role of gut–microbiota–brain axis

Neurobiology of Disease, 2022
Multiple sclerosis (MS) is the most common demyelinating disease that attacks the central nervous system. We recently reported that the new antidepressant (R)-ketamine could ameliorate the disease progression in experimental autoimmune encephalomyelitis ...
Xingming Wang, Lijia Chang, Xiayun Wan, Yunfei Tan, Youge Qu, Jiajing Shan, Yong Yang, Li Ma, Kenji Hashimoto   +8 more
doaj  

Progesterone alleviates neural behavioral deficits and demyelination with reduced degeneration of oligodendroglial cells in cuprizone-induced mice. [PDF]

PLoS ONE, 2013
Demyelination occurs widely in neurodegenerative diseases. Progesterone has neuroprotective effects, is known to reduce the clinical scores and the inflammatory response.
Jian-Ning Ye, Xing-Shu Chen, Le Su, Yun-Lai Liu, Qi-Yan Cai, Xiao-Li Zhan, Yan Xu, Shi-Fu Zhao, Zhong-Xiang Yao   +8 more
doaj   +1 more source

Type 2 Innate Lymphoid Cells Induce CNS Demyelination in an HSV-IL-2 Mouse Model of Multiple Sclerosis

iScience, 2020
Summary: We previously reported that infection of different mouse strains with a recombinant HSV-1 expressing IL-2 (HSV-IL-2) caused CNS demyelination.
Satoshi Hirose, Pedram Shafiei Jahani, Shaohui Wang, Ujjaldeep Jaggi, Kati Tormanen, Jack Yu, Mihoko Kato, Omid Akbari, Homayon Ghiasi   +8 more
doaj  

Inhibition of Piezo1 attenuates demyelination in the central nervous system

Glia, 2019
Piezo1 is a mechanosensitive ion channel that facilitates the translation of extracellular mechanical cues to intracellular molecular signaling cascades through a process termed, mechanotransduction.
María Velasco-Estevez, K. K. Gadalla, Núria Liñan-Barba, Stuart Cobb, K. Dev, Graham K Sheridan   +5 more
semanticscholar   +1 more source

Interruptible demyelination in avian riboflavin deficient neuropathy

Cell & Bioscience
Background and aims The evolution of demyelination in individual internodes remains unclear although it has been noticed the paranodal demyelination precedes internodal demyelination in neuropathies with diverse aetiologies.
Zhao Cai
doaj   +1 more source