Results 31 to 40 of about 104,217 (332)

Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination

Nature Communications, 2019
Oligodendrocyte precursor cells (OPCs) are abundant in the adult central nervous system, and have the capacity to regenerate oligodendrocytes and myelin. However, in inflammatory diseases such as multiple sclerosis (MS) remyelination is often incomplete.
L. Kirby, Jing Jin, J. Cardona, Matthew D. Smith, Kyle A. Martin, Jingya Wang, Hayley J Strasburger, Leyla R Herbst, M. Alexis, J. Karnell, Todd S. Davidson, Ranjan Dutta, J. Goverman, D. Bergles, P. Calabresi   +14 more
semanticscholar   +1 more source

CHARACTERIZATION OF SIGNAL CONDUCTION ALONG DEMYELINATED AXONS BY ACTION-POTENTIAL-ENCODED SECOND HARMONIC GENERATION [PDF]

Journal of Innovative Optical Health Sciences, 2014
Action-potential-encoded optical second harmonic generation (SHG) has been recently proposed for use in detecting the axonal damage in patients with demyelinating diseases.
ZHI-HUI LUO, JIANG-XU CHEN, YI-MEI HUANG, HONG-QIN YANG, JU-QIANG LIN, HUI LI, SHU-SEN XIE   +6 more
doaj   +1 more source

Enhanced axonal response of mitochondria to demyelination offers neuroprotection: implications for multiple sclerosis

Acta Neuropathologica, 2020
Axonal loss is the key pathological substrate of neurological disability in demyelinating disorders, including multiple sclerosis (MS). However, the consequences of demyelination on neuronal and axonal biology are poorly understood.
Simon Licht-Mayer, G. Campbell, Marco A Cañizares, A. Mehta, A. Gane, Katie McGill, Aniket Ghosh, Alexander Fullerton, Niels Menezes, J. Dean, Jordon Dunham, Sarah Al-Azki, G. Pryce, S. Zandee, Chao Zhao, M. Kipp, Kenneth J. Smith, D. Baker, D. Altmann, S. Anderton, Y. Kap, J. Laman, B. Hart, Moses Rodriguez, Ralf Watzlawick, J. Schwab, R. Carter, N. Morton, M. Zagnoni, R. Franklin, R. Mitchell, S. Fleetwood-Walker, D. Lyons, S. Chandran, H. Lassmann, B. Trapp, D. Mahad   +36 more
semanticscholar   +1 more source

Deletion of CD38 Suppresses Glial Activation and Neuroinflammation in a Mouse Model of Demyelination

Frontiers in Cellular Neuroscience, 2019
CD38 is an enzyme that catalyzes the synthesis of cyclic adenosine diphosphate-ribose from nicotinamide adenine dinucleotide (NAD+). We recently reported that this molecule regulates the maturation and differentiation of glial cells such as astrocytes ...
Jureepon Roboon, Tsuyoshi Hattori, Hiroshi Ishii, Mika Takarada‐Iemata, Thuong Manh Le, Yoshitake Shiraishi, Norio Ozaki, Yasuhiko Yamamoto, Akira Sugawara, Hiroshi Okamoto, Haruhiro Higashida, Yasuko Kitao, Osamu Hori   +12 more
openalex   +2 more sources

Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus infection

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Microglia are the resident phagocytic cells of the central nervous system (CNS). During demyelination, a condition in which myelin sheaths are damaged and removed from neurons due to inflammation, microglia can play both harmful and ...
A. Sariol, Samantha R. Mackin, Merri-Grace Allred, Chen Ma, Yu Zhou, Qinran Zhang, Xiufen Zou, J. Abrahante, D. Meyerholz, S. Perlman   +9 more
semanticscholar   +1 more source

Central Pontine Myelinosis and Osmotic Demyelination Syndrome.

Deutsches Ärzteblatt International, 2019
BACKGROUND Osmotic demyelination syndrome (ODS), which embraces central pontine myelinolysis (CPM) and extrapontine myelinosis (EPM), is often underdiagnosed in clinical practice, but can be fatal.
J. Lambeck, M. Hieber, A. Dressing, W. Niesen   +3 more
semanticscholar   +1 more source

Autotaxin and lysophosphatidic acid₁ receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidylcholine

Molecular Pain, 2010
Background Although neuropathic pain is frequently observed in demyelinating diseases such as Guillain-Barré syndrome and multiple sclerosis, the molecular basis for the relationship between demyelination and neuropathic pain behaviors is poorly ...
Aoki Junken, Niwa Masami, Ueda Mutsumi, yano Ryo, Matsushita Yosuke, Uchida Hitoshi, Nagai Jun, Chun Jerold, Ueda Hiroshi   +8 more
doaj   +1 more source

Secondary parkinsonism due to osmotic demyelination syndrome: a case report

The Egyptian Journal of Internal Medicine, 2015
Hyponatremia is a common medical problem often found in the elderly and is due to poor intake, medical comorbidities, and medications. Central to the management of this condition is the use of normal and hypertonic saline, besides the use of ...
Waseem R Dar, Najeeb U Sofi, Muzamil Latief, Imtiyaz A Dar, Moomin Hussain   +4 more
doaj   +1 more source

Clinical manifestations and imaging features of white matter demyelination in older patients

Journal of International Medical Research, 2020
Objective To investigate the clinical manifestations and imaging features of older patients with white matter demyelination diagnosed by magnetic resonance imaging (MRI).
Jian Li, Yi-Ming Zhao
doaj   +1 more source

CNS Demyelination with TNF-α Blockers

Current Neurology and Neuroscience Reports, 2017
Tumor necrosis factor–α (TNF-α) blockers are a popular therapeutic choice in a number of inflammatory diseases. Thus far, five TNF- α blockers have been approved for clinical use (etanercept, infliximab, adalimumab, golimumab. and certolizumab).
E. Kemanetzoglou, E. Andreadou
semanticscholar   +1 more source