Results 51 to 60 of about 97,922 (342)

Interruptible demyelination in avian riboflavin deficient neuropathy

Cell & Bioscience
Background and aims The evolution of demyelination in individual internodes remains unclear although it has been noticed the paranodal demyelination precedes internodal demyelination in neuropathies with diverse aetiologies.
Zhao Cai
doaj   +1 more source

Meningeal inflammation and cortical demyelination in acute multiple sclerosis

Annals of Neurology, 2018
Cortical gray matter (GM) pathology, involving demyelination and neurodegeneration, associated with meningeal inflammation, could be important in determining disability progression in multiple sclerosis (MS).
Ryan J. Bevan, Rhian Evans, Lauren Griffiths, Lewis M. Watkins, M. Rees, R. Magliozzi, I. Allen, G. McDonnell, Rachel Kee, M. Naughton, D. Fitzgerald, R. Reynolds, J. Neal, O. Howell   +13 more
semanticscholar   +1 more source

Olfactory System and Demyelination [PDF]

The Anatomical Record, 2013
ABSTRACTWithin the central nervous system, the olfactory system represents one of the most exciting scenarios since it presents relevant examples of long‐life sustained neurogenesis and continuous axonal outgrowth from the olfactory epithelium with the subsequent plasticity phenomena in the olfactory bulb.
García González, Diego, Murcia-Belmonte, V, Clemente, D, De Castro, F   +3 more
openaire   +4 more sources

Durable B‐Cell Impairment While Sparing IgA B Cells After Ocrelizumab Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Ocrelizumab (OCR), a humanized anti‐CD20 monoclonal antibody, is highly efficient in relapsing–remitting multiple sclerosis (RR‐MS). We assessed early cellular B‐cell profiles in patients prior to OCR treatment, on OCR treatment, and after 15 months of therapy discontinuation.
Alexandra Garcia, Stephane Rodriguez, Emilie Dugast, Christine Lebrun‐Frenay, Eric Thouvenot, Jérôme de Sèze, Emmanuelle Le Page, Sandra Vukusic, Inès Doghri, Eric Berger, Olivier Casez, Pierre Labauge, Aurélie Ruet, Catarina Raposo, Fabienne Le Frère, Arnaud B. Nicot, Sandrine Wiertlewski, Pierre‐Antoine Gourraud, Laure Michel, Laureline Berthelot, David‐Axel Laplaud   +20 more
wiley   +1 more source

Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain

Cell Reports, 2020
Summary: Neonatally transplanted human glial progenitor cells (hGPCs) can myelinate the brains of myelin-deficient shiverer mice, rescuing their phenotype and survival.
Martha S. Windrem, Steven J. Schanz, Lisa Zou, Devin Chandler-Militello, Nicholas J. Kuypers, Maiken Nedergaard, Yuan Lu, John N. Mariani, Steven A. Goldman   +8 more
doaj   +1 more source

Healthy Properties of a New Formulation of Pomegranate-Peel Extract in Mice Suffering from Experimental Autoimmune Encephalomyelitis

Molecules, 2022
A new formulation of a pomegranate-peel extract (PEm) obtained by PUAE (Pulsed Ultrasound-Assisted Extraction) and titrated in both ellagic acid (EA) and punicalagin is proposed, characterized and then analyzed for potential health properties in mice ...
Giulia Vallarino, Annalisa Salis, Elena Lucarini, Federica Turrini, Guendalina Olivero, Alessandra Roggeri, Gianluca Damonte, Raffaella Boggia, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Anna Pittaluga   +10 more
doaj   +1 more source

LncRNA GAS5 inhibits microglial M2 polarization and exacerbates demyelination

EMBO Reports, 2017
The regulation of inflammation is pivotal for preventing the development or reoccurrence of multiple sclerosis (MS). A biased ratio of high‐M1 versus low‐M2 polarized microglia is a major pathological feature of MS.
Dingya Sun, Zhongwang Yu, Xue Fang, Mingdong Liu, Yingyan Pu, Qi Shao, Dan Wang, Xiaolin Zhao, Aijun Huang, Z. Xiang, Chao Zhao, R. Franklin, Li Cao, Cheng He   +13 more
semanticscholar   +1 more source

Clozapine administration enhanced functional recovery after cuprizone demyelination.

PLoS ONE, 2019
The atypical antipsychotic agent, clozapine, is used to treat a variety of neurological disorders including schizophrenia and Parkinson's disease and readily crosses the blood brain barrier to interact with a wide range of neuroreceptors including those ...
Nikki Templeton, Bronwyn Kivell, Amy McCaughey-Chapman, Bronwen Connor, Anne Camille La Flamme   +4 more
doaj   +1 more source

Strain differences in cuprizone induced demyelination

Cell & Bioscience, 2017
Background Multiple sclerosis (MS) is a severe neurological disorder, characterized by demyelination of the central nervous system (CNS), and with a prevalence of greater than 2 million people worldwide.
Qili Yu, Ryan Hui, Jiyoung Park, Yangyang Huang, Alexander W. Kusnecov, Cheryl F. Dreyfus, Renping Zhou   +6 more
doaj   +1 more source

Viral Induced Demyelination [PDF]

Brain Pathology, 2001
Viral induced demyelination, in both humans and rodent models, has provided unique insights into the cell biology of oligodendroglia, their complex cell‐cell interactions and mechanisms of myelin destruction. They illustrate mechanisms of viral persistence, including latent infections in which no infectious virus is readily evident, virus reactivation ...
David R. Hinton, Stephen A. Stohlman
openaire   +2 more sources