Results 51 to 60 of about 104,217 (332)
Imaging of the optic nerve in acute vision loss—A pictorial review
Kerala Journal of Ophthalmology, 2023 Optic nerves are paired cranial nerves and are unique as they represent the extension of the central nervous system (CNS). It is involved in many cases of acute vision loss, and magnetic resonance imaging (MRI) plays an important role in the detection of
Namrata +5 more
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The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen +5 more
wiley +1 more source
Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain
Cell Reports, 2020 Summary: Neonatally transplanted human glial progenitor cells (hGPCs) can myelinate the brains of myelin-deficient shiverer mice, rescuing their phenotype and survival.
Martha S. Windrem +8 more
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The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain
Brain : a journal of neurology, 2016 Multiple sclerosis is characterized by widespread primary demyelination and progressive degeneration, driven by heterogeneous mechanisms. Haider et al.
Lukas Haider +9 more
semanticscholar +1 more source
Autosomal Recessive Spastic Ataxia of Charlevoix‐Saguenay in Two Half‐Siblings
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Autosomal recessive spastic ataxia of Charlevoix‐Saguenay (ARSACS) is caused by biallelic pathogenic variants in the SACS gene. We report the clinical, radiologic and neurophysiologic features of a pair of half‐siblings who presented with progressive cerebellar ataxia, peripheral neuropathy and upper motor neuron signs.
Dennis Yeow +6 more
wiley +1 more source
Strain differences in cuprizone induced demyelination
Cell & Bioscience, 2017 Background Multiple sclerosis (MS) is a severe neurological disorder, characterized by demyelination of the central nervous system (CNS), and with a prevalence of greater than 2 million people worldwide.
Qili Yu +6 more
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Neurology International, 2021 Distinguishing between tumefactive demyelinating lesions (TDLs) and brain tumors in multiple sclerosis (MS) can be challenging. A progressive course is highly common with brain tumors in MS and no single neuroimaging technique is foolproof when ...
Chantal Kahovec +2 more
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LncRNA GAS5 inhibits microglial M2 polarization and exacerbates demyelination
EMBO Reports, 2017 The regulation of inflammation is pivotal for preventing the development or reoccurrence of multiple sclerosis (MS). A biased ratio of high‐M1 versus low‐M2 polarized microglia is a major pathological feature of MS.
Dingya Sun +13 more
semanticscholar +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Mutations in myelin regulatory factor (MYRF) are linked to demyelinating disorders. We report a 38‐year‐old male who developed acute symmetric leukoencephalopathy mimicking a stroke following an influenza A virus infection. While clinical symptoms markedly improved with corticosteroids, MRI revealed persistent white matter lesions, contrasting
Jinghan Hu +5 more
wiley +1 more source
Clozapine administration enhanced functional recovery after cuprizone demyelination.
PLoS ONE, 2019 The atypical antipsychotic agent, clozapine, is used to treat a variety of neurological disorders including schizophrenia and Parkinson's disease and readily crosses the blood brain barrier to interact with a wide range of neuroreceptors including those ...
Nikki Templeton +4 more
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