Results 51 to 60 of about 80,361 (185)

(R)-ketamine ameliorates demyelination and facilitates remyelination in cuprizone-treated mice: A role of gut–microbiota–brain axis

Neurobiology of Disease, 2022
Multiple sclerosis (MS) is the most common demyelinating disease that attacks the central nervous system. We recently reported that the new antidepressant (R)-ketamine could ameliorate the disease progression in experimental autoimmune encephalomyelitis ...
Xingming Wang, Lijia Chang, Xiayun Wan, Yunfei Tan, Youge Qu, Jiajing Shan, Yong Yang, Li Ma, Kenji Hashimoto   +8 more
doaj  

Sex Differences in the Behavioural Aspects of the Cuprizone-Induced Demyelination Model in Mice

Brain Sciences, 2022
Multiple sclerosis is an autoimmune disease characterised by demyelination in the central nervous system. The cuprizone-induced demyelination model is often used in mice to test novel treatments for multiple sclerosis.
Kelly F. Paton, Sheein Hong, Andrew Biggerstaff, Bronwyn M. Kivell   +3 more
doaj   +1 more source

The chemokine receptor CXCR2 and coronavirus-induced neurologic disease. [PDF]

, 2013
Inoculation with the neurotropic JHM strain of mouse hepatitis virus (MHV) into the central nervous system (CNS) of susceptible strains of mice results in an acute encephalomyelitis in which virus preferentially replicates within glial cells while ...
Akwa, Bajetto, Bakshi, Barnett, Bauer, Belperio, Bergmann, Bergmann, Bergmann, Bergmann, Boyle, Brett S. Marro, Buchmeier, Burrer, Carbajal, Carlson, Castro, Cervantes-Barragan, Cheever, Chen, Cho, Coughlan, Danik, Dorf, Epstein, Field, Filipovic, Filipovic, Fischer, Fleming, Fleury, Flynn, Frohman, Glabinski, Glaser, Glass, Glass, Glass, Glass, Glass, Goebels, Gonzalez, Gonzalez, Gorio, Hauser, Held, Held, Hiremath, Holmes, Horuk, Hosking, Hosking, Houtman, Ireland, Jason G. Weinger, Juedes, Kapil, Katz-Levy, Kerstetter, Kielian, Kim, Klein, Kroenke, Lane, Lane, Lin, Lin, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Londhe, Londhe, Lu, Malone, Marques, Marsh, Marten, Marten, Marten, Martin, Martin P. Hosking, Masters, Matthews, Matthews, Matute, Mazaleuskaya, McMahon, Merabova, Miller, Minagawa, Moser, Nguyen, Omari, Omari, Omari, Padovani-Claudio, Parra, Parra, Pearce, Perlman, Pewe, Pewe, Phares, Phares, Popivanova, Ramakrishna, Ramakrishna, Ramakrishna, Raman, Rempel, Rempel, Robinson, Roth-Cross, Roth-Cross, Saas, Savarin, Schumacher, Scott, Smith, Stiles, Stiles, Stohlman, Stohlman, Strieter, Sui, Sun, Tarassishin, Templeton, Thomas E. Lane, Tirotta, Tirotta, Tonai, Tran, Traugott, Traugott, Trifilo, Trifilo, Tsai, Tschen, Tuohy, Tuohy, Turbic, Ubogu, van der Hoek, van der Hoek, Versteeg, Walsh, Walsh, Wang, Wareing, Watson, Weiss, Wengner, Wolpe, Woo, Woodroofe, Wu, Wu, Xia, Xue, Yong, Zhang, Zhang, Zhou, Zhou, Zhou, Zhou, Zhou, Zuo   +172 more
core   +1 more source

White Matter Injury After Intracerebral Hemorrhage

Frontiers in Neurology, 2021
Spontaneous intracerebral hemorrhage (ICH) accounts for 15% of all stroke cases. ICH is a devastating form of stroke associated with high morbidity, mortality, and disability.
Xiongjie Fu, Guoyang Zhou, Jianfeng Zhuang, Chaoran Xu, Hang Zhou, Yucong Peng, Yang Cao, Hanhai Zeng, Jianru Li, Feng Yan, Lin Wang, Gao Chen   +11 more
doaj   +1 more source

Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery

eLife, 2016
Demyelination in MS disrupts nerve signals and contributes to axon degeneration. While remyelination promises to restore lost function, it remains unclear whether remyelination will prevent axonal loss.
Feng Mei, Feng Mei, K. Lehmann-Horn, Yun-An A. Shen, Kelsey A. Rankin, K. Stebbins, D. Lorrain, Kara Pekarek, Sharon A Sagan, L. Xiao, C. Teuscher, H. Büdingen, J. Wess, J. J. Lawrence, A. Green, S. Fancy, S. Zamvil, J. Chan   +17 more
semanticscholar   +1 more source

Restoration of axon conduction and motor deficits by therapeutic treatment with glatiramer acetate. [PDF]

, 2014
Glatiramer acetate (GA; Copaxone) is an approved drug for the treatment of multiple sclerosis (MS). The underlying multifactorial anti-inflammatory, neuroprotective effect of GA is in the induction of reactive T cells that release immunomodulatory ...
Hayardeny, Liat, Ichwan, Daniel, Khalaj, Anna J, Moore, Spencer, Patel, Rhusheet, Tiwari-Woodruff, Seema K, Yoon, JaeHee   +6 more
core   +2 more sources

Interruptible demyelination in avian riboflavin deficient neuropathy

Cell & Bioscience
Background and aims The evolution of demyelination in individual internodes remains unclear although it has been noticed the paranodal demyelination precedes internodal demyelination in neuropathies with diverse aetiologies.
Zhao Cai
doaj   +1 more source

Type 2 Innate Lymphoid Cells Induce CNS Demyelination in an HSV-IL-2 Mouse Model of Multiple Sclerosis

iScience, 2020
Summary: We previously reported that infection of different mouse strains with a recombinant HSV-1 expressing IL-2 (HSV-IL-2) caused CNS demyelination.
Satoshi Hirose, Pedram Shafiei Jahani, Shaohui Wang, Ujjaldeep Jaggi, Kati Tormanen, Jack Yu, Mihoko Kato, Omid Akbari, Homayon Ghiasi   +8 more
doaj  

Valproic acid suppresses cuprizone-induced hippocampal demyelination and anxiety-like behavior by promoting cholesterol biosynthesis

Neurobiology of Disease, 2021
Myelin consists of several layers of tightly compacted membranes that form an insulating sheath around axons. These membranes are highly enriched in cholesterol, which is essential for the myelination process.
Xinjian Zhu, Yuanyuan Yao, Yang Hu, Jiurong Yang, Canyu Zhang, Yuqi He, Aifeng Zhang, Xiufang Liu, Chenchen Zhang, Guangming Gan   +9 more
doaj  

Meningeal inflammation and cortical demyelination in acute multiple sclerosis

Annals of Neurology, 2018
Cortical gray matter (GM) pathology, involving demyelination and neurodegeneration, associated with meningeal inflammation, could be important in determining disability progression in multiple sclerosis (MS).
Ryan J. Bevan, Rhian Evans, Lauren Griffiths, Lewis M. Watkins, M. Rees, R. Magliozzi, I. Allen, G. McDonnell, Rachel Kee, M. Naughton, D. Fitzgerald, R. Reynolds, J. Neal, O. Howell   +13 more
semanticscholar   +1 more source