Results 61 to 70 of about 37,089 (146)

Proteome profile of peripheral myelin in healthy mice and in a neuropathy model

eLife, 2020
Proteome and transcriptome analyses aim at comprehending the molecular profiles of the brain, its cell-types and subcellular compartments including myelin.
Sophie B Siems, Olaf Jahn, Maria A Eichel, Nirmal Kannaiyan, Lai Man N Wu, Diane L Sherman, Kathrin Kusch, Dörte Hesse, Ramona B Jung, Robert Fledrich, Michael W Sereda, Moritz J Rossner, Peter J Brophy, Hauke B Werner   +13 more
doaj   +1 more source

The Effect of Levothyroxine on Lysolecithin-Induced Local Demyelination in Optic Chiasm of Male Rats

مجله دانشکده پزشکی اصفهان, 2017
Background: One of the significant problems in multiple sclerosis (MS) is damage to the visual system, which is the result of demyelination. Studies have suggested a link between central nervous system demyelinating diseases and thyroid disorders, and ...
Bahman Rashidi, Cobra Payghani, Fatemeh Khani, Aryan Rafieezadeh, Hojjatallah Alaei, Parham Reisi   +5 more
doaj  

TRPV4 Inhibition Improved Myelination and Reduced Glia Reactivity and Inflammation in a Cuprizone-Induced Mouse Model of Demyelination

Frontiers in Cellular Neuroscience, 2018
The inhibition of demyelination and the promotion of remyelination are both considerable challenges in the therapeutic process for many central nervous system (CNS) diseases.
Meiying Liu, Xuan Liu, Lei Wang, Yu Wang, Fuxing Dong, Jian Wu, Xuebin Qu, Yanan Liu, Zhi’an Liu, Hong-bin Fan, Ruiqin Yao   +10 more
semanticscholar   +1 more source

Experimental Demyelination and Axonal Loss Are Reduced in MicroRNA-146a Deficient Mice

Frontiers in Immunology, 2018
Background The cuprizone (CPZ) model of multiple sclerosis (MS) was used to identify microRNAs (miRNAs) related to in vivo de- and remyelination. We further investigated the role of miR-146a in miR-146a-deficient (KO) mice: this miRNA is differentially ...
N. Martin, V. Molnar, G. Szilagyi, M. Elkjaer, A. Nawrocki, Justyna Okarmus, A. Wlodarczyk, Eva K. Thygesen, M. Palkovits, F. Gallyas, M. Larsen, H. Lassmann, E. Benedikz, T. Owens, Å. Svenningsen, Z. Illés   +15 more
semanticscholar   +1 more source

Subependymal Zone-Derived Oligodendroblasts Respond to Focal Demyelination but Fail to Generate Myelin in Young and Aged Mice

Stem Cell Reports, 2017
Two populations of oligodendrogenic progenitors co-exist within the corpus callosum (CC) of the adult mouse. Local, parenchymal oligodendrocyte progenitor cells (pOPCs) and progenitors generated in the subependymal zone (SEZ) cytogenic niche.
Ilias Kazanis, Kimberley A. Evans, Evangelia Andreopoulou, Christina Dimitriou, Christos Koutsakis, Ragnhildur Thora Karadottir, Robin J.M. Franklin   +6 more
doaj   +1 more source

Development of a PET radioligand for potassium channels to image CNS demyelination

Scientific Reports, 2018
Central nervous system (CNS) demyelination represents the pathological hallmark of multiple sclerosis (MS) and contributes to other neurological conditions.
P. Brugarolas, Jorge E. Sánchez-Rodríguez, Hsiu-Ming Tsai, F. Basuli, Shih-Hsun Cheng, Xiang Zhang, A. Caprariello, Jérôme J. Lacroix, R. Freifelder, D. Murali, O. DeJesus, Robert H Miller, R. Swenson, Chin-Tu Chen, P. Herscovitch, D. Reich, F. Bezanilla, B. Popko   +17 more
semanticscholar   +1 more source

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

Nature Communications, 2015
Autoimmunity and macrophage recruitment into the central nervous system (CNS) are critical determinants of neuroinflammatory diseases. However, the mechanisms that drive immunological responses targeted to the CNS remain largely unknown.
J. Ryu, Mark A. Petersen, Sara G. Murray, K. M. Baeten, A. Meyer‐Franke, Justin P. Chan, Eirini Vagena, C. Bedard, Michael R. Machado, Pamela E. Rios Coronado, T. Prod’homme, I. Charo, H. Lassmann, J. Degen, S. Zamvil, K. Akassoglou   +15 more
semanticscholar   +1 more source

Desmielinização e remielinização após múltiplas injeções intramedulares de brometo de etídio em ratos Wistar Demyelination and remyelination after multiple intramedullary injections of ethidium bromide in Wistar rats

Arquivos de Neuro-Psiquiatria, 1997
O modelo de desmielinização do brometo de etídio foi utilizado para estudar a reação do sistema nervoso central frente a múltiplos episódios de desmielinização tóxica.
Cristina Gevehr Fernandes, Dominguita Lühers Graça, Luis Antônio Violin Dias Pereira   +2 more
doaj   +1 more source

Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis

Acta Neuropathologica, 2017
Cortical demyelination is a widely recognized hallmark of multiple sclerosis (MS) and correlate of disease progression and cognitive decline. The pathomechanisms initiating and driving gray matter damage are only incompletely understood.
Nielsen Lagumersindez-Denis, Claudia Wrzos, M. Mack, A. Winkler, F. van der Meer, M. Reinert, Heiko Hollasch, A. Flach, H. Brühl, E. Cullen, C. Schlumbohm, E. Fuchs, C. Linington, A. Barrantes-Freer, I. Metz, C. Wegner, D. Liebetanz, M. Prinz, W. Brück, C. Stadelmann, S. Nessler   +20 more
semanticscholar   +1 more source

Cuprizone Demyelination of the Corpus Callosum in Mice Correlates with Altered Social Interaction and Impaired Bilateral Sensorimotor Coordination

ASN Neuro, 2009
For studies of remyelination in demyelinating diseases, the cuprizone model of CC (corpus callosum) demyelination has experimental advantages that include overall size, proximity to neural stem cells of the subventricular zone, and correlation with a ...
Norah Hibbits, Ravinder Pannu, T John Wu, Regina C Armstrong   +3 more
doaj   +1 more source