Results 71 to 80 of about 97,922 (342)
Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance
Advanced Science, EarlyView.Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai +5 more
wiley +1 more source
Frontiers in Molecular Neuroscience, 2016 Although the precise mechanism underlying initial lesion development in multiple sclerosis (MS) remains unclear, CNS inflammation has long been associated with demyelination, and axonal degeneration.
Junjie Liang +11 more
doaj +1 more source
Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis
Advanced Science, EarlyView.Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu +17 more
wiley +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Myelin sheaths insulate the neuronal axons and speed the transmission of electrical impulses. The demyelination process occurs in many human diseases, including multiple sclerosis (MS).
Sitao Zhang +11 more
semanticscholar +1 more source
Advanced Science, EarlyView.Engineered macrophage‐derived exosomes overexpressing GNA12 and GNA13 reprogram glial cells to promote neuroprotection and neural regeneration following SCI. A chitosan‐based thermosensitive hydrogel enables sustained intranasal exosome delivery, bypassing systemic barriers and enhancing therapeutic efficacy.
Yangyang Wang +13 more
wiley +1 more source
Developmental Medicine & Child Neurology, 2018 Myelin oligodendrocyte glycoprotein (MOG) antibodies have a strong association with acute disseminated encephalomyelitis (ADEM) in children, and bilateral and recurrent optic neuritis in children and adults.
S. Ramanathan +7 more
semanticscholar +1 more source
Osmotic demyelination syndrome [PDF]
BMJ Case Reports, 2014 A 25-year-old man presented with progressive impairment of consciousness, ocular bobbing and tetraparesis. Since the age of 3 he had received substitution therapy for central diabetes insipidus after surgical treatment of a craniopharyngioma. Accidental disruption of his intranasal desmopressin treatment 1 day before admission led to an increase of ...
Gisa Ellrichmann +3 more
openaire +3 more sources
Bioinspired Engineering beyond Homeostasis
Advanced Intelligent Systems, EarlyView.This perspective article introduces systems biology as the unifying theoretical framework behind bioinspired engineering. As an example, it explores how disruptions in multiscale biological systems, associated with pathological states, can be viewed as localized failure modes of biological cooperation showing emergent advantages that can inspire ...
Rosalia Moreddu
wiley +1 more source
The Effect of Levothyroxine on Lysolecithin-Induced Local Demyelination in Optic Chiasm of Male Rats
مجله دانشکده پزشکی اصفهان, 2017 Background: One of the significant problems in multiple sclerosis (MS) is damage to the visual system, which is the result of demyelination. Studies have suggested a link between central nervous system demyelinating diseases and thyroid disorders, and ...
Bahman Rashidi +5 more
doaj