Results 71 to 80 of about 37,089 (146)

Is it worth considering circulating microRNAs in multiple sclerosis?

Frontiers in Immunology, 2016
New evidence has highlighted that miRNA production and trafficking can be dysregulated in both autoimmmune and neurological disorders. Multiple sclerosis (MS) in particular is an autoimmune pathology leading to neurodegeneration.
Ferdinand eJagot, Nathalie eDavoust
doaj   +1 more source

Demyelination Causes Adult CNS Progenitors to Revert to an Immature State and Express Immune Cues That Support Their Migration

Journal of Neuroscience, 2015
The declining efficiency of myelin regeneration in individuals with multiple sclerosis has stimulated a search for ways by which it might be therapeutically enhanced.
Sarah Moyon, Anne-Laure Dubessy, M. Aigrot, M. Trotter, Jeffrey K. Huang, L. Dauphinot, M. Potier, C. Kerninon, S. Mélik Parsadaniantz, R. Franklin, C. Lubetzki   +10 more
semanticscholar   +1 more source

A BIOCHEMICAL AND MORPHOLOGIC STUDY OF MYELINATION AND DEMYELINATION [PDF]

, 1958
Guido Majno, Manfred L. Karnovsky
openalex   +1 more source

Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model

Acta Neuropathologica Communications, 2017
In neuroinflammatory disorders such as multiple sclerosis, the physiological function of the blood-brain barrier (BBB) is perturbed, particularly in demyelinating lesions and supposedly secondary to acute demyelinating pathology.
Stefan A Berghoff, Tim Düking, L. Spieth, J. Winchenbach, S. Stumpf, Nina Gerndt, Kathrin Kusch, T. Ruhwedel, W. Möbius, G. Saher   +9 more
semanticscholar   +1 more source

Microcephaly with Extensive Calcium Deposits and Demyelination [PDF]

, 1954
George A. Jervis
openalex   +1 more source

Microglial SIRPα regulates the emergence of CD11c+ microglia and demyelination damage in white matter

eLife, 2019
A characteristic subset of microglia expressing CD11c appears in response to brain damage. However, the functional role of CD11c+ microglia, as well as the mechanism of its induction, are poorly understood.
Miho Sato-Hashimoto, Tomomi Nozu, Riho Toriba, Ayano Horikoshi, Miho Akaike, Kyoko Kawamoto, Ayaka Hirose, Yuriko Hayashi, Hiromi Nagai, Wakana Shimizu, Ayaka Saiki, Tatsuya Ishikawa, Ruwaida Elhanbly, Takenori Kotani, Yoji Murata, Yasuyuki Saito, Masae Naruse, Koji Shibasaki, Per-Arne Oldenborg, Steffen Jung, Takashi Matozaki, Yugo Fukazawa, Hiroshi Ohnishi   +22 more
doaj   +1 more source

Phase and Electron Microscopic Studies of Experimental Demyelination [PDF]

, 1961
Henry deF. Webster, David Spiro, Byron H. Waksman, Raymond D. Adams   +3 more
openalex   +1 more source

Histological validation of fast macromolecular proton fraction mapping as a quantitative myelin imaging method in the cuprizone demyelination model

Scientific Reports, 2017
Cuprizone-induced demyelination in mice is a frequently used model in preclinical multiple sclerosis research. A recent quantitative clinically-targeted MRI method, fast macromolecular proton fraction (MPF) mapping demonstrated a promise as a myelin ...
M. Khodanovich, I. Sorokina, V. Glazacheva, A. Akulov, N. Nemirovich-Danchenko, A. Romashchenko, T. Tolstikova, L. Mustafina, V. Yarnykh   +8 more
semanticscholar   +1 more source

In silico modelling of neuron signal impact of cytokine storm-induced demyelination

Open Biology
In this study, we develop an in silico model of a neuron’s behaviour under demyelination caused by a cytokine storm to investigate the effects of viral infections in the brain.
Geoflly L. Adonias, Harun Siljak, Sasitharan Balasubramaniam, Michael Taynnan Barros   +3 more
doaj   +1 more source

Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone

eLife, 2018
Myelin, the insulating sheath around axons, supports axon function. An important question is the impact of mild myelin disruption. In the absence of the myelin protein proteolipid protein (PLP1), myelin is generated but with age, axonal function ...
Elizabeth A Gould, Nicolas Busquet, Douglas Shepherd, Robert M Dietz, Paco S Herson, Fabio M Simoes de Souza, Anan Li, Nicholas M George, Diego Restrepo, Wendy B Macklin   +9 more
doaj   +1 more source