Results 81 to 90 of about 97,922 (342)
Frontiers in Cellular Neuroscience, 2018 The inhibition of demyelination and the promotion of remyelination are both considerable challenges in the therapeutic process for many central nervous system (CNS) diseases.
Meiying Liu +10 more
semanticscholar +1 more source
A New Model of Cuprizone-Mediated Demyelination/Remyelination
ASN Neuro, 2014 In the central nervous system, demyelinating diseases, such as multiple sclerosis, result in devastating long-term neurologic damage, in part because of the lack of effective remyelination in the adult human brain.
Hilary H. Sachs +4 more
doaj +1 more source
Proteome profile of peripheral myelin in healthy mice and in a neuropathy model
eLife, 2020 Proteome and transcriptome analyses aim at comprehending the molecular profiles of the brain, its cell-types and subcellular compartments including myelin.
Sophie B Siems +13 more
doaj +1 more source
Transient auditory nerve demyelination as a new mechanism for hidden hearing loss
Nature Communications, 2017 Hidden hearing loss (HHL) is a recently described auditory neuropathy believed to contribute to speech discrimination and intelligibility deficits in people with normal audiological tests.
Guoqiang Wan, G. Corfas
semanticscholar +1 more source
A Drosophila model of prion disease and its metabolic changes in the brain
Animal Models and Experimental Medicine, EarlyView.We developed a Drosophila model for prion disease, and flies were capable of expressing the hamster prion protein (HaPrP) under the control of the GAL4/UAS system. The model exhibited some characteristics of the disease in mammals and displayed alterations in protein, sphingolipid, and carbohydrate metabolism. Preliminary applications have demonstrated
Dongdong Wang +14 more
wiley +1 more source
Research advances in dysphagia animal models
Animal Models and Experimental Medicine, EarlyView.This review systematically summarizes the establishment, evaluation, and detection of dysphagia animal models in stroke, Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) in three kinds of experimental animals (including rodents, nonhuman primates, and other mammals), providing a basis for the selection of appropriate animal models of ...
Junhui Bai +5 more
wiley +1 more source
Development of a PET radioligand for potassium channels to image CNS demyelination
Scientific Reports, 2018 Central nervous system (CNS) demyelination represents the pathological hallmark of multiple sclerosis (MS) and contributes to other neurological conditions.
P. Brugarolas +17 more
semanticscholar +1 more source
, 2007 Acute disseminated encephalomyelitis (ADEM) is a demyelinating disease that affects all ages, except children less than 2 years. It occurs during the course of various infections, particularly the acute exanthematous diseases of childhood (measles, rubella, chickenpox, and smallpox immunization), other common viral infections (i.e., Epstein-Barr virus,
openaire +1 more source
Annals of Neurology, EarlyView.Objective Spinal cord (SC) atrophy correlates with and predicts the underlying progressive biology in active and non‐active multiple sclerosis (MS), thereby providing a biomarker for clinical trials and patient management. Initiation of disease‐modifying therapy (DMT) may be followed by early pronounced central nervous system (CNS) volume loss due to ...
Simone Sacco +26 more
wiley +1 more source