Results 81 to 90 of about 37,089 (146)

Cause and prevention of demyelination in a model multiple sclerosis lesion

Annals of Neurology, 2016
Demyelination is a cardinal feature of multiple sclerosis, but it remains unclear why new lesions form, and whether they can be prevented. Neuropathological evidence suggests that demyelination can occur in the relative absence of lymphocytes, and with ...
R. Desai, A. Davies, M. Tachrount, M. Kasti, F. Laulund, X. Golay, Kenneth J. Smith   +6 more
semanticscholar   +1 more source

Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain

Cell Reports, 2020
Summary: Neonatally transplanted human glial progenitor cells (hGPCs) can myelinate the brains of myelin-deficient shiverer mice, rescuing their phenotype and survival.
Martha S. Windrem, Steven J. Schanz, Lisa Zou, Devin Chandler-Militello, Nicholas J. Kuypers, Maiken Nedergaard, Yuan Lu, John N. Mariani, Steven A. Goldman   +8 more
doaj  

Myelin Recovery in Multiple Sclerosis: The Challenge of Remyelination

Brain Sciences, 2013
Multiple sclerosis (MS) is the most common demyelinating and an autoimmune disease of the central nervous system characterized by immune-mediated myelin and axonal damage, and chronic axonal loss attributable to the absence of myelin sheaths.
Edward L. Hogan, Ewa Kurowska, Naren L. Banik, Maria Podbielska   +3 more
doaj   +1 more source

The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures

Journal of Neuroinflammation, 2016
BackgroundBAF312 (Siponimod) is a dual agonist at the sphingosine-1 phosphate receptors, S1PR1 and S1PR5. This drug is currently undergoing clinical trials for the treatment of secondary progressive multiple sclerosis (MS).
C. O’Sullivan, A. Schubart, A. Mir, K. Dev   +3 more
semanticscholar   +1 more source

The vagus nerve-dependent lung-brain axis mediates brain demyelination following acute lung injury

Brain, Behavior, & Immunity - Health
Patients with acute lung injury (ALI) often experience psychiatric and neurological symptoms; however, the precise underlying mechanisms remain unclear.
Dan Xu, Mingming Zhao, Guilin Liu, Tingting Zhu, Yi Cai, Rumi Murayama, Yong Yue, Kenji Hashimoto   +7 more
doaj  

A possible means of monitoring the progress of demyelination in multiple sclerosis: effect of body temperature on visual perception of double light flashes. [PDF]

, 1976
R. J. Galvin, D. Regan, James Heron
openalex   +1 more source

Increased levels of myelin basic protein transcripts gene in virus-induced demyelination [PDF]

, 1986
Krister Kristensson, Kathryn V. Holmes, Cynthia S. Duchala, N. K. Zeller, R. A. Lazzarini, M. Dubois-Dalcq   +5 more
openalex   +1 more source

Demyelination in mice resulting from infection with a mutant of Semliki Forest virus [PDF]

, 1981
B. J. Sheahan, Perry Barrett, Gerald J. Atkins   +2 more
openalex   +1 more source

Progressive ataxia due to central demyelination in Rottweiler dogs [PDF]

, 1986
W. Wouda, J.J. van Nes
openalex   +1 more source

LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model

Journal of Pharmacological Sciences, 2018
Lysophosphatidic acid (LPA) and LPA1 receptor signaling play a crucial role in the initiation of peripheral nerve injury-induced neuropathic pain through the alternation of pain-related genes/proteins expression and demyelination.
Ryoko Tsukahara, Shinji Yamamoto, Keisuke Yoshikawa, Mari Gotoh, Tamotsu Tsukahara, Hiroyuki Neyama, Satoshi Ishii, Noriyuki Akahoshi, Keisuke Yanagida, Hayakazu Sumida, Masatake Araki, Kimi Araki, Ken-ichi Yamamura, Kimiko Murakami-Murofushi, Hiroshi Ueda   +14 more
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