Results 31 to 40 of about 11,507,286 (389)

The role of CD103+ Dendritic cells in the intestinal mucosal immune system.

Frontiers in Immunology, 2011
While dendritic cells (DC) are central to the induction and regulation of adaptive immunity, these cells are very heterogenous and specific subsets can be characterized based on the expression of cell surface markers and functional properties. Intestinal
Darren Thomas Ruane, Ed Charles Lavelle
doaj   +1 more source

Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity

Nature Communications, 2020
Autoimmune connective tissue diseases arise in a stepwise fashion from asymptomatic preclinical autoimmunity. Type I interferons have a crucial role in the progression to established autoimmune diseases.
A. Psarras, A. Alase, A. Antanaviciute, I. Carr, Md Yuzaiful Md Yusof, M. Wittmann, P. Emery, G. Tsokos, E. Vital   +8 more
semanticscholar   +1 more source

Generation of inducible immortalized dendritic cells with proper immune function in vitro and in vivo.

PLoS ONE, 2013
Dendritic cells are the professional antigen presenting cells of innate immunity and key players in maintaining the balance of immune responses. Studies with dendritic cells are mainly limited by their low numbers in vivo and their difficult maintenance ...
Cornelia Richter, Sebastian Thieme, Joanna Bandoła, Magdalena Laugsch, Konstantinos Anastassiadis, Sebastian Brenner   +5 more
doaj   +1 more source

Computational convergence of the path integral for real dendritic morphologies [PDF]

, 2012
Neurons are characterised by a morphological structure unique amongst biological cells, the core of which is the dendritic tree. The vast number of dendritic geometries, combined with heterogeneous properties of the cell membrane, continue to challenge ...
Brand, Samuel, Caudron, Quentin, Donnelly, Simon R., Timofeeva, Yulia   +3 more
core   +2 more sources

Human plasmacytoid dendritic cells and cutaneous melanoma [PDF]

, 2020
The prognosis of metastatic melanoma (MM) patients has remained poor for a long time. However, the recent introduction of effective target therapies (BRAF and MEK inhibitors for BRAFV600-mutated MM) and immunotherapies (anti-CTLA-4 and anti-PD-1) has ...
Bugatti, Mattia, Consoli, Francesca, Monti, Matilde, Vermi, William, Vescovi, Raffaella   +4 more
core   +2 more sources

Genome Wide Transcriptome Analysis of Dendritic Cells Identifies Genes with Altered Expression in Psoriasis [PDF]

, 2013
Activation of dendritic cells by different pathogens induces the secretion of proinflammatory mediators resulting in local inflammation. Importantly, innate immunity must be properly controlled, as its continuous activation leads to the development of ...
Filkor, Katalin, Hegedűs, Zoltán, Kemény, Lajos, Kondorosi, Éva, Nagy, István, Szász, András, Tubák, Vilmos   +6 more
core   +5 more sources

Targeting Human Dendritic Cells with Lewis X Modified Liposomes [PDF]

, 2010
In this short report, we demonstrate that liposomes bearing the Lewis X trisaccharide on the surface (“Awesosomes”) efficiently target human dendritic cells.
Lucie Kalvodova, Yongmin Zhang
core   +2 more sources

Anti-tumor immunity controlled through mRNA m6A and YTHDF1 in dendritic cells

Nature, 2019
There is growing evidence that tumour neoantigens have important roles in generating spontaneous antitumour immune responses and predicting clinical responses to immunotherapies1,2.
Dali Han, Jun Liu, Chuanyuan Chen, Lihui Dong, Yi Liu, Renbao Chang, Xiaona Huang, Yuanyuan Liu, Jianying Wang, U. Dougherty, M. Bissonnette, Bin Shen, R. Weichselbaum, M. Xu, Chuan He   +14 more
semanticscholar   +1 more source

Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma

Nature Communications, 2019
The Wnt pathway regulates anti-tumour immunity in melanoma. Here, the authors show that, in lung adenocarcinoma, secretion of the ligand Wnt1 induces immune resistance by impairing the ability of dendritic cells to cross-prime T cells, and that blocking ...
Dimitra Kerdidani, Panagiotis Chouvardas, Ares Rocanin Arjo, Ioanna Giopanou, Giannoula Ntaliarda, Yu Amanda Guo, Mary Tsikitis, Georgios Kazamias, Konstantinos Potaris, Georgios T. Stathopoulos, Spyros Zakynthinos, Ioannis Kalomenidis, Vassili Soumelis, George Kollias, Maria Tsoumakidou   +14 more
doaj   +1 more source

MOLECULAR AND CELLULAR MECHANISMS MEDIATED BY DENDRITIC CELLS INVOLVED IN THE INDUCTION OF TOLERANCE

Медицинская иммунология, 2017
Autoimmune diseases  and  complications  after  transplantation  operations are  major   public health  problem, as they often  lead to deterioration in the quality  of life, reduce  work capacity  and  disability in the  population.
S. V. Sennikov, E. V. Kulikova, N. Yu. Knauer, Yu. N. Khantakova   +3 more
doaj   +1 more source