Simultaneous determination of Deoxynivalenol, Deoxynivalenol-3-Glucoside and Nivalenol in wheat grains by HPLC-PDA with immunoaffinity column cleanup [PDF]
Food Analytical Methods, 2016 Deoxynivalenol-3-glucoside (D3G) is a modified mycotoxin formed by the metabolism of plants through the conjugation of deoxynivalenol (DON) with glucose.
A Dall’Erta +39 more
core +5 more sources
Humans significantly metabolize and excrete the mycotoxin deoxynivalenol and its modified form deoxynivalenol-3-glucoside within 24 hours [PDF]
Sci Rep, 2018 AbstractFor the first time, a comprehensive human intervention study was conducted to unravel the urinary excretion profile and metabolism of the fungal metabolite deoxynivalenol (DON) and its modified form deoxynivalenol-3-glucoside (DON-3-glucoside). Twenty volunteers were restricted in consuming cereals and cereal-based foods for 4 days. At day 3, a
Arnau Vidal +7 more
europepmc +7 more sources
Glucose-Dependent Insulinotropic Polypeptide and Substance P Mediate Emetic Response Induction by Masked Trichothecene Deoxynivalenol-3-Glucoside through Ca2+ Signaling [PDF]
Toxins (Basel), 2022 Deoxynivalenol (DON), the most naturally-occurring trichothecenes, may affect animal and human health by causing vomiting as a hallmark of food poisoning. Deoxynivalenol-3-glucoside (D3G) usually co-occurs with DON as its glucosylated form and is another emerging food safety issue in recent years.
Zihui Qin +7 more
europepmc +5 more sources
Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in rats
Toxicol Lett, 2012 Deoxynivalenol-3-β-D-glucoside (D3G), a plant metabolite of the Fusarium mycotoxin deoxynivalenol (DON), might be hydrolyzed in the digestive tract of mammals, thus contributing to the total dietary DON exposure of individuals. Yet, D3G has not been considered in regulatory limits set for DON for foodstuffs due to the lack of in vivo data.
Veronika Nagl +7 more
europepmc +4 more sources
Hydrolytic fate of deoxynivalenol-3-glucoside during digestion
Toxicol Lett, 2011 Deoxynivalenol-3-β-D-glucoside (D3G), a plant phase II metabolite of the Fusarium mycotoxin deoxynivalenol (DON), occurs in naturally contaminated wheat, maize, oat, barley and products thereof. Although considered as a detoxification product in plants, the toxicity of this substance in mammals is currently unknown.
Franz Berthiller +6 more
europepmc +4 more sources
Risk Assessment Considering the Bioavailability of 3-β-d-Glucosides of Deoxynivalenol and Nivalenol through Food Intake in Korea [PDF]
Toxins, 2023 Deoxynivalenol and nivalenol are major type B trichothecenes and the most frequently occurring mycotoxins worldwide. Their 3-β-d-glucoside forms have recently become a safety management issue.
Sang Yoo Lee +4 more
doaj +2 more sources
The Metabolic Fate of Deoxynivalenol and Its Acetylated Derivatives in a Wheat Suspension Culture: Identification and Detection of DON-15-O-Glucoside, 15-Acetyl-DON-3-O-Glucoside and 15-Acetyl-DON-3-Sulfate [PDF]
Toxins, 2015 Deoxynivalenol (DON) is a protein synthesis inhibitor produced by the Fusarium species, which frequently contaminates grains used for human or animal consumption.
Clemens Schmeitzl +8 more
doaj +2 more sources
Chemical Synthesis of Deoxynivalenol-3-β-d-[13C6]-glucoside and Application in Stable Isotope Dilution Assays [PDF]
Molecules, 2016 Modified mycotoxins have been gaining importance in recent years and present a certain challenge in LC-MS/MS analysis. Due to the previous lack of a labeled isotopologue of the modified mycotoxin deoxynivalenol-3-glucoside, in our study we synthesized ...
Katharina Habler +2 more
doaj +2 more sources
Occurrence of Fusarium Mycotoxins and Their Modified Forms in Forage Maize Cultivars [PDF]
Toxins, 2021 Forage maize is often infected by mycotoxin-producing Fusarium fungi during plant growth, which represent a serious health risk to exposed animals. Deoxynivalenol (DON) and zearalenone (ZEN) are among the most important Fusarium mycotoxins, but little is
Tim Birr +8 more
doaj +4 more sources
Concurrent Quantification of Deoxynivalenol, Its Derivatives, and Nivalenol in Pet Food Using QuEChERS Combined with LC-MS/MS [PDF]
ToxinsIn the current research, we optimized a simultaneous method for quantifying deoxynivalenol (DON) and its derivative forms, deoxynivalenol-3-glucoside (D3G), 3-acetyl-deoxynivalenol (3-AcDON), 15-acetyl-deoxynivalenol (15-AcDON), and nivalenol (NIV), in ...
Chae-Eun Yeo +7 more
doaj +2 more sources