Results 121 to 130 of about 2,734 (187)

Proteomic Analysis of a Poplar Cell Suspension Culture Suggests a Major Role of Protein S-Acylation in Diverse Cellular Processes [PDF]

, 2016
S-acylation is a reversible post-translational modification (PTM) of proteins known to be involved in membrane targeting, subcellular trafficking and the determination of a great variety of functional properties of proteins.
Bruce William Fouke, Erik eMalm, Joseph R. Weber, Vaibhav eSrivastava, Vincent eBulone, Vincent eBulone   +5 more
core   +2 more sources

Defective anterograde protein-trafficking contributes to endoplasmic reticulum-stress in a CLN1 disease model

Neurobiology of Disease
Lysosomal storage disorders (LSDs) represent 70 inherited metabolic diseases, in most of which neurodegeneration is a devastating manifestation. The CLN1 disease is a fatal neurodegenerative LSD, caused by inactivating mutations in the CLN1 gene encoding
Nisha Plavelil, Abhilash P. Appu, K.C. Gopal, Avisek Mondal, Neil Perkins, Anil B. Mukherjee   +5 more
doaj   +1 more source

Measuring S-Depalmitoylation Activity In Vitro and In Live Cells with Fluorescent Probes [PDF]

, 2019
S-palmitoylation is a reversible lipid posttranslational modification (PTM) that can mediate protein localization, trafficking, interaction with membranes, and a host of other biophysical characteristics. Over the past decade, a suite of chemoproteomic strategies have uncovered the breadth of S-palmitoylation, revealing widespread susceptibility to ...
Rahul S, Kathayat, Bryan C, Dickinson
openaire   +2 more sources

Glutamate receptor subunit 2 serine 880 phosphorylation modulates synaptic transmission and mediates plasticity in CA1 pyramidal cells [PDF]

, 2003
The cytoplasmic C termini of AMPA receptor subunits contain PDZ ( postsynaptic density 95/Discs large/zona occludens 1) ligand domains that can control their synaptic trafficking during plasticity.
Huganir, R., Malinow, R., Seidenman, K. J., Steinberg, J. P.   +3 more
core   +1 more source

Nitric Oxide in Skeletal Muscle: Role on Mitochondrial Biogenesis and Function [PDF]

, 2012
Nitric oxide (NO) has been implicated in several cellular processes as a signaling molecule and also as a source of reactive nitrogen species (RNS). NO is produced by three isoenzymes called nitric oxide synthases (NOS), all present in skeletal muscle ...
Godinho, Rosely Oliveira, Rodrigues, Gabriela Silva, Tengan, Celia Harumi   +2 more
core   +2 more sources

Spatial regulation of the acylation cycle by thioesterase auto-depalmitoylation

, 2015
The acylation cycle is a reaction diffusion mechanism thatmaintains H/N-Ras localization on the plasma membrane (PM)by countering the equilibration of palmitoylated H/N-Rasproteins to endomembranes. The thioesterases APT1/2perform this critical function of depalmitoylating mislocalizedH/N-Ras proteins, thereby allowing them to diffuse rapidly andre ...
Nachiket Vartak, Bjoern Papke, Hedberg, Christian, Lisaweta Rossmanek   +3 more
openaire   +1 more source

Palmitoylation as a Functional Regulator of Neurotransmitter Receptors

Neural Plasticity, 2018
The majority of neuronal proteins involved in cellular signaling undergo different posttranslational modifications significantly affecting their functions.
Vladimir S. Naumenko, Evgeni Ponimaskin
doaj   +1 more source

GABAAR-PPT1 palmitoylation homeostasis controls synaptic transmission and circuitry oscillation

Translational Psychiatry
The infantile neuronal ceroid lipofuscinosis, also called CLN1 disease, is a fatal neurodegenerative disease caused by mutations in the CLN1 gene encoding palmitoyl protein thioesterase 1 (PPT1).
Jia Tong, Jingjing Gao, Yawei Qi, Ziyan Gao, Qianqian Wang, Yang Liu, Tiangang Yuan, Minglong Ren, Guixia Yang, Zhaoyue Li, Jin Li, Hongyuan Sun, Xing Zhao, Yeung-Yeung Leung, Yonghui Mu, Jiamin Xu, Chengbiao Lu, Shiyong Peng, Lihao Ge   +18 more
doaj   +1 more source

The Role of Reversible Palmitoylation in Regulating Diverse Biological Processes [PDF]

, 2015
It is well established that covalent lipid-modification of proteins can play an important role in the spatial and temporal organization of many intracellular signaling proteins.
Maktabi, Mohammad H.
core   +1 more source

Palmitoylation-dependent modulation of CD36 trafficking and signaling integrates lipid uptake with metabolic disease pathogenesis

Pharmacological Research
CD36 is a multifunctional lipid transporter that facilitates long-chain fatty acid uptake and orchestrates metabolic signaling in energy-demanding tissues.
Mingxun Li, Haoran Jia, Lei Zhang, Peng Chen, Shimeng Wang, Yongjiang Mao, Zhangping Yang   +6 more
doaj   +1 more source