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Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice

Nature Communications
Toll-like receptor 9 (TLR9) recognizes self-DNA and plays intricate roles in systemic lupus erythematosus (SLE). However, the molecular mechanism regulating the endosomal TLR9 response is incompletely understood.
Hai Ni +9 more
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Depalmitoylation of CAAX motif proteins. Protein structural determinants of palmitate turnover rate.

The Journal of biological chemistry, 1995
In the present study, we examined the effect of amino acid substitutions on the rate of turnover of palmitate bound to a model "CAAX" motif protein H-Ras. These experiments were designed to shed light on the specificity of the process that removes palmitate from prenylated proteins. H-Ras, protein A-Ras fusion constructs, and constructs with amino acid
J Y, Lu, S L, Hofmann
openaire +1 more source

The 5-hydroxytryptamine(4a) receptor is palmitoylated at two different sites and acylation is critically involved in regulation of receptor constitutive activity [PDF]

, 2002
Bickmeyer, Ulf +6 more
core

Editorial: Role of protein palmitoylation in synaptic plasticity and neuronal differentiation, volume II

Frontiers in Synaptic Neuroscience
Kevin P. Koster, William N. Green
doaj +1 more source

The palmitoylation code in cell death signaling: from molecular mechanisms to therapeutic opportunities. [PDF]