Results 61 to 70 of about 10,903 (206)
Food Frontiers, Volume 7, Issue 1, January 2026.Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli +8 more
wiley +1 more source
Hoogsteen base pairs proximal and distal to echinomycin binding sites on DNA [PDF]
, 1987 Forms of the DNA double helix containing non-Watson-Crick base-pairing have been discovered recently based on x-ray diffraction analysis of quinoxaline antibiotic-oligonucleotide complexes.
Dervan, Peter B., Mendel, David
core +2 more sources
The V‐Shaped Hamilton Receptors: A Paradigmatic Multipurpose Scaffold
ChemistryOpen, Volume 15, Issue 1, January 2026.This manuscript explores the historical context and significance of molecular recognition in relation to Hamilton‐type receptors. It concludes with a discussion on future prospects for the development of novel functionalized Hamilton‐type receptors. It is hoped that this collection will offer new insights and directions for the supramolecular chemistry
Shafieq Ahmad Wagay, Rashid Ali
wiley +1 more source
Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E
Nature Communications, 2019 The depsipeptide Lysocin E has antibacterial activity against methicillin-resistant Staphylococcus aureus. Here, the authors developed a high-throughput one-bead-on-compound method for the synthesis and screening lysocin E derivatives, with several hits ...
Hiroaki Itoh +7 more
doaj +1 more source
Exploring the sequence space of unknown oligomers and polymers
Cell Reports Physical Science, 2021 Summary: The characterization of the chemistry of life on earth has been facilitated by developments in analysis and sequencing of bio-oligomers using tandem mass spectrometry (MS/MS).
David Doran +5 more
doaj +1 more source
A contribution to the nomenclature of depsipeptides [PDF]
Journal of Peptide Science, 2003 AbstractDepsipeptides, also called peptolides, are a class of peptidic compounds in which an amide bond has been replaced with an ester bond. The literature does not clearly display rules for the nomenclature of such compounds. Here a method is proposed to transcribe drawn depsipeptide structures in one‐line text.
Sorin V, Filip, Florine, Cavelier
openaire +2 more sources
Molecular characterization of enterococci harboring genotype and phenotype incongruence related to glycopeptide resistance isolated in Brazilian hospitals [PDF]
, 2008 Three Enterococcus faecalis and one Enterococcus faecium strains were characterized by plasmid profile, pulsed-field gel electrophoresis (PFGE) and determination of antimicrobial minimal inhibitory concentrations. VanA elements were characterized by Long
DARINI, Ana Lucia da Costa +3 more
core +3 more sources
Robust Synthesis of Prebiotic Precursors in Drying Reactions of Amino Acids and Keto Acids
ChemSystemsChem, Volume 8, Issue 1, January 2026.Drying conditions drive reactions between amino acids and keto acids, generating a wide variety of small, reactive species, highlighting for the first time the potential significance of drying reactions in proto‐metabolism on early Earth. Condensation‐dehydration reactions are critical to both metabolism and polymerization in extant biology, and their ...
Eliav Marland +7 more
wiley +1 more source
Consecutive isocyanide-based multicomponent reactions: synthesis of cyclic pentadepsipeptoids
Beilstein Journal of Organic Chemistry, 2014 The synthesis of six cyclic depsipeptoids inspired by the natural depsipeptide sansalvamide A is described. An efficient and fast synthetic strategy was developed using a combination of consecutive isocyanide-based multicomponent reactions (Ugi and ...
Angélica de Fátima S. Barreto +3 more
doaj +1 more source
SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A.
PLoS ONE, 2016 In order to expand the repertoire of antifungal compounds a novel, high-throughput phenotypic drug screen targeting fungal phosphatidylserine (PS) synthase (Cho1p) was developed based on antagonism of the toxin papuamide A (Pap-A).
Chelsi D Cassilly +6 more
doaj +1 more source