Results 171 to 180 of about 8,483 (198)

Solvolytic depolymerization of chondroitin and dermatan sulfates [PDF]

Carbohydrate Research, 2009
It is essential to establish a library of glycosaminoglycan oligosaccharides from the chondroitin and dermatan sulfates to investigate their biological functions and structure-activity relationships (SARs). There are several approaches to obtain oligosaccharides using chemical and enzymatic degradation procedures; however, purification of each ...
Robert J. Linhardt, Kenji Sato, Noriko Sakamoto, Shinobu Sakai, Toshihiko Toida, Saori Hosoyama   +5 more
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Dermatan sulfate and chondroitin 6-sulfate conformations

Biochemical and Biophysical Research Communications, 1973
Abstract X-ray diffraction patterns show that dermatan sulfate in oriented, crystalline films occurs as two or three or eight-fold helices. The two-fold helix has a greater axial rise per disaccharide residue [ h = 9.6 A ] than the corresponding chondroitin 6-sulfate helix [ h = 9.3 A ] .
David W.L. Hukins, J.M. Guss, Struther Arnott, Martin B. Mathews   +3 more
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Synthesis of disaccharide fragments of dermatan sulfate

Carbohydrate Research, 1989
Condensation of crystalline methyl 2-azido-4,6-O-benzylidene-2-deoxy-beta-D-galactopyranoside with methyl (2,3,4-tri-O-acetyl-alpha-L-idopyranosyl bromide)uronate in dichloromethane, in the presence of silver triflate and molecular sieve, provided 54% of methyl 2-azido-4,6-O-benzylidene-2-deoxy-3-O-(methyl 2,3,4-tri-O-acetyl-alpha-L-idopyranosyluronate)
MARRA, Alberto, XIA D, PETITOU M, SINAY P.   +3 more
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Immunology of Chondroitin/Dermatan Sulfate

1995
Variable substitutions and locations of the sulfate esters along the backbone of chondroitin/dermatan sulfate chains, combined with their carbohydrate structures, present topographies to immune systems which can be recognized as antigenic. This has led to the development of a number of monoclonal antibodies which recognize distinct epitopes in the ...
Ronald J. Midura, Anna Plaas, Vincent C. Hascall, J. M. Sorrell   +3 more
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Dermatan sulfates of normal and scarred fascia

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2001
We evaluated the composition of dermatan sulfates (DS) derived from 23 samples of normal and 23 samples of scarred fascia lata. We analyzed the molecular weight of intact DS chains and the length of chain regions comprising: (1) clusters of L-iduronate-containing disaccharides ("iduronic sections"); (2) clusters of D-glucuronate-containing ...
Ewa M Koźma, Andrzej Głowacki, Krystyna Olczyk   +2 more
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Dermatan sulfate as a potential therapeutic agent

General Pharmacology: The Vascular System, 1995
1. Dermatan sulfate is a linear, sulfated polysaccharide and is a glycosaminoglycan component of several important proteoglycans. This minireview discusses the biosynthesis, structure and biological function of dermatan sulfate proteoglycans. 2.
Ronald E. Hileman, Robert J. Linhardt
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Pharmacological profile of a native dermatan sulfate

Thrombosis Research, 1992
We performed different "in vivo" investigations to study the pharmacological properties of a native DS: anti-thrombosis by the stasis model, bleeding potential by tail transection bleeding time and template bleeding time, and profibrinolysis by a growing thrombus model and by an established thrombus model.
R. Alvarez, F. Fussi, F.M. Santoro
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Plasmatic dermatan sulfate and chondroitin sulfate determination in mucopolysaccharidoses

Journal of Pharmaceutical and Biomedical Analysis, 2013
The evaluation of plasmatic galactosaminoglycans, dermatan sulfate (DS) and chondroitin sulfate (CS) can be helpful in the early identification of MPS patients, also considering that primary storage of one type of GAG can lead to secondary accumulation of other lysosomal substrates.
Francesca Maccari, Tiziana Galeazzi, Fabio Galeotti, Lucia Padella, Giovanni V. Coppa, Nicola Volpi, Lucia Zampini, Lucia Santoro, Orazio Gabrielli   +8 more
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Advances in the Analysis of Chondroitin/Dermatan Sulfate

2006
Publisher Summary Chondroitin/dermatan sulfate (CS/DS) is a glycosaminoglycan (GAG) found in extracellular matrix (ECM) and cell surface and participates in various ECM and cell–ECM interactions. It is made from the alternate addition of glucuronic acid (GlcA) and N‐acetylgalactosamine (GalNAc).
Demitrios H. Vynios, M. Stylianou, Irene-Eva Triantaphyllidou   +2 more
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Dermatan sulfate and heparan sulfate as a biomarker for mucopolysaccharidosis I

Journal of Inherited Metabolic Disease, 2010
AbstractMucopolysaccharidosis I (MPS I) is an autosomal recessive disorder caused by deficiency of α‐L‐iduronidase leading to accumulation of its catabolic substrates, dermatan sulfate (DS) and heparan sulfate (HS), in lysosomes. This results in progressive multiorgan dysfunction and death in early childhood.
Shunji Tomatsu, Nobuo Sakura, Mitsuru Kubota, Hirotaka Oikawa, María L. Gutiérrez, Adriana M. Montaño, Tadao Orii, Luis A. Barrera, Masaru Fukushi, Kazuhiro Kida, Vu Chi Dung, Yasuyuki Suzuki, Talita Giacomet de Carvalho, Toshihiro Oguma, Seiji Yamaguchi   +14 more
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