Results 181 to 190 of about 8,483 (198)
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Neutralization of dermatan sulfate and by protamine sulfate and polybrene
Thrombosis Research, 1989The neutralization of the anticoagulant, anti-thrombin, and bleeding effects of dermatan sulfate (DS), a potential antithrombotic agent, was investigated. Protamine sulfate (PS) and hexadimethrine bromide (Polybrene), which reverse the anticoagulant effect of heparin, also neutralized DS in vitro.
Pierre Sie +5 more
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Potential Therapeutic Application of Chondroitin Sulfate/Dermatan Sulfate
Current Drug Discovery Technologies, 2008Glycosaminoglycans (GAGs) are complex polysaccharides, which play important roles in cell growth, differentiation, morphogenesis, cell migration, and bacterial/viral infections. Major GAGs include heparin (Hep)/heparan sulfate, and chondroitin sulfate (CS)/dermatan sulfate (DS).
Shuhei Yamada, Kazuyuki Sugahara
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Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate
Current Opinion in Structural Biology, 2003Recent glycobiology studies have suggested fundamental biological functions for chondroitin, chondroitin sulfate and dermatan sulfate, which are widely distributed as glycosaminoglycan sidechains of proteoglycans in the extracellular matrix and at cell surfaces.
Hiroshi Kitagawa +5 more
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Suppression of Experimental Autoimmune Encephalomyelitis by Dermatan Sulfate
Cellular Immunology, 1999The effect of dermatan sulfate (DS) on the treatment of Lewis rats with experimental autoimmune encephalomyelitis (EAE) was examined. DS, a sulfated glycosaminoglycan, has been reported to exhibit anticoagulant and fibrinolytic activities. DS treatment (50 mg/kg/day) facilitates recovery from the clinical manifestations of EAE.
Yuji Inaba +6 more
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Chondroitin sulfate/dermatan sulfate sulfatases from mammals and bacteria
Glycoconjugate Journal, 2016Sulfatases that specifically catalyze the hydrolysis of the sulfate groups on chondroitin sulfate (CS)/dermatan sulfate (DS) poly- and oligosaccharides belong to the formylglycine-dependent family of sulfatases and have been widely found in various mammalian and bacterial organisms.
Shumin Wang +2 more
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β-N-Acetylhexosaminidase Active on Dermatan Sulfate
Enzyme, 1975The dodecasaccharide obtained by treating dermatan sulfate with testicular hyaluronidase, chondroitinase AC, and beta-glucuronidase was incubated with diluted, normal human serum at pH 4.5 or 7.0 followed by chondro-4-sulfatase at pH 7.0. Analyses of the reaction products indicate release of hexosamine but not further degradation of the substrate.
Singh J, Di Ferrante N, Coppa Gv
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Chondroitin/dermatan sulfate in the central nervous system
Current Opinion in Structural Biology, 2007In the central nervous system (CNS) chondroitin sulfate proteoglycans, as one of the major barrier-forming molecules, influence cell migration patterns and axon pathfinding. By contrast, chondroitin sulfate side chains often form hybrid chains with dermatan sulfate and serve as a neural stem cell marker and neurogenic/neuritogenic molecules involved in
Tadahisa Mikami, Kazuyuki Sugahara
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The dermatan sulfate proteoglycans of the adult human meniscus
Journal of Orthopaedic Research, 1992AbstractThe dermatan sulfate proteoglycans decorin and biglycan were extracted from pooled adult human menisci with 4 M guanidinium chloride and purified by successive cesium chloride density gradient centrifugation, ion exchange chromatography, and gel filtration.
Robert J. White, Peter J. Roughley
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Pharmacokinetics of Heparin and of Dermatan Sulfate: Clinical Implications
1992The pharmacokinetic data concerning heparin and dermatan sulfate are usually based upon the disappearance of the biological activities generated after parenteral administration, and not upon the direct determination of their chemical concentrations. At least for heparin, these biological activities are mainly related to the polysaccharide chain length ...
Pierre Sie +4 more
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Dermatan Sulfate in Pharmaceutical Heparins
Thrombosis and Haemostasis, 1987Arthur S. Perlin +3 more
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